Review
Cell Biology
Runyu Miao, Xinyi Fang, Yanjiao Zhang, Jiahua Wei, Yuxin Zhang, Jiaxing Tian
Summary: The balance of iron homeostasis is crucial for proper endocrine function, and an imbalance in iron levels has been linked to the development of various endocrine diseases. Ferroptosis, an iron-dependent form of cell death, has emerged as an important process in the pathogenesis and progression of type 2 diabetes mellitus (T2DM). Understanding the mechanisms of iron metabolism and ferroptosis in T2DM may lead to improved disease management. This review discusses the connections between metabolic pathways, molecular mechanisms, and potential treatment targets related to iron metabolism and ferroptosis in T2DM.
CELL DEATH & DISEASE
(2023)
Article
Engineering, Environmental
Bin Wang, Wei Liu, Linling Yu, Zi Ye, Man Cheng, Weihong Qiu, Min Zhou, Jixuan Ma, Xing Wang, Meng Yang, Jiahao Song, Weihong Chen
Summary: This study found that exposure to acrolein may lead to glucose dyshomeostasis and an increased risk of type 2 diabetes. Increased concentrations of acrolein metabolites were associated with decreased insulin sensitivity and increased fasting glucose levels and the risk of diabetes. Furthermore, changes in certain biomarkers may mediate these associations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Xiaohui Pan, Shibing Tao, Nanwei Tong
Summary: Neurotransmitters play a vital role in regulating glucose homeostasis in pancreatic islets, and dysfunction of neurotransmitter receptors is associated with the development of type 2 diabetes. Targeting different transmitter systems holds great potential in preventing and treating type 2 diabetes and other metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aisha Musaazi Sebunya Nakitto, John H. Muyonga, Yusuf Byenkya Byaruhanga, Anika E. Wagner
Summary: The review discusses the pathogenesis of type 2 diabetes mellitus and potential antidiabetic effects of phytochemicals, specifically focusing on Solanum anguivi Lam. fruits (SALF). Consuming fruits and vegetables rich in phytochemicals may prevent and support conservative treatment of T2DM, particularly in low-income countries. The antidiabetic properties of SALF are attributed to the various phytochemicals present, including saponins, phenolics, alkaloids, ascorbic acid, and flavonoids, but further research is needed to fully understand their mechanisms of action.
Article
Endocrinology & Metabolism
Sofiya Gancheva, Sabine Kahl, Dominik Pesta, Lucia Mastrototaro, Bedair Dewidar, Klaus Strassburger, Ehsan Sabah, Irene Esposito, Juergen Weiss, Theresia Sarabhai, Martin Wolkersdorfer, Thomas Fleming, Peter Nawroth, Marcel Zimmermann, Andreas S. Reichert, Matthias Schlensak, Michael Roden
Summary: Loss of hepatic mitochondrial adaptation characterizes NASH and type 2 diabetes or hepatic fibrosis and may thereby favor accelerated disease progression.
Article
Endocrinology & Metabolism
Sofiya Gancheva, Sabine Kahl, Dominik Pesta, Lucia Mastrototaro, Bedair Dewidar, Klaus Strassburger, Ehsan Sabah, Irene Esposito, Jurgen Weiss, Theresia Sarabhai, Martin Wolkersdorfer, Thomas Fleming, Peter Nawroth, Marcel Zimmermann, Andreas S. Reichert, Matthias Schlensak, Michael Roden
Summary: Individuals with type 2 diabetes have a higher risk of progressing from nonalcoholic fatty liver to steatohepatitis, fibrosis, and cirrhosis. The hepatic mitochondrial function in NASH patients with and without type 2 diabetes differs, impacting disease progression.
Article
Cardiac & Cardiovascular Systems
Ram Prasad, Jason L. Floyd, Mariana Dupont, Angela Harbour, Yvonne Adu-Agyeiwaah, Bright Asare-Bediako, Dibyendu Chakraborty, Kara Kichler, Aayush Rohella, Sergio Li Calzi, Regina Lammendella, Justin Wright, Michael E. Boulton, Gavin Y. Oudit, Mohan K. Raizada, Bruce R. Stevens, Qiuhong Li, Maria B. Grant
Summary: The components of the systemic and intestinal renin-angiotensin system have been found to be associated with gut barrier permeability, glucose homeostasis, systemic inflammation, and the progression of diabetic retinopathy. Changes in gut-regulated components of the immune system, gut leakage markers, and angiotensin II were observed in T1D patients and mice, and were assessed for relevance.
CIRCULATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xiaoxia Duan, Zhenhua Chen, Congying Xia, Rong Zhong, Li Liu, Lu Long
Summary: This study shows a significant association between exposure to ambient VOCs and an increased risk of diabetes and impaired glucose homeostasis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Celine Osinski, Lea Le Gleau, Christine Poitou, Juan de Toro-Martin, Laurent Genser, Magali Fradet, Hedi Antoine Soula, Armelle Leturque, Corinne Blugeon, Laurent Jourdren, Edwige Ludiwyne Hubert, Karine Clement, Patricia Serradas, Agnes Ribeiro
Summary: The study revealed that type 2 diabetes is associated with reduced GLP-1 cell differentiation and proglucagon maturation, leading to low GLP-1-cell density in obese individuals.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Endocrinology & Metabolism
Josephine H. Li, Lukasz Szczerbinski, Adem Y. Dawed, Varinderpal Kaur, Jennifer N. Todd, Ewan R. Pearson, Jose C. Florez
Summary: Individuals with a higher genetic burden for T2D experience a greater acute and sustained response to sulfonylureas, suggesting potential for targeted pharmacologic intervention.
Review
Nutrition & Dietetics
Wanbao Yang, Wen Jiang, Shaodong Guo
Summary: This article reviews the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, highlighting the importance of adjusting the intake of beneficial food compounds for the prevention of insulin resistance and type 2 diabetes.
Review
Pharmacology & Pharmacy
Khaled Benchoula, Aditya Arya, Ishwar S. Parhar, Wong Eng Hwa
Summary: This review discusses the importance of maintaining balanced glucose homeostasis in preventing or treating diabetes and obesity, as well as the complexity of activating and inhibiting glucose production. It focuses on the key role of FoxO1 in obesity-induced insulin susceptibility and provides potential therapeutic approaches.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Giuseppe Loffredo, Luca Rinaldi, Christian Catalini, Klodian Gjeloshi, Gaetana Albanese, Anna Di Martino, Giovanni Docimo, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Diabetic patients are often affected by coronary microvascular dysfunction, a complex condition whose pathogenesis involves hyperglycemia and insulin resistance. This dysfunction contributes to cardiac events and heart failure, and no specific treatment exists. However, certain antidiabetic drugs may have protective effects.
Article
Endocrinology & Metabolism
Jiao Wang, Adrian I. Campos, Luis M. Garcia-Marin, Miguel E. Renteria, Lin Xu
Summary: This study used multiple genetic methods to investigate the causal associations between sleep apnea and snoring with type 2 diabetes, taking into account the role of BMI. The results showed that the associations between sleep apnea and snoring with type 2 diabetes were mainly driven by BMI. BMI accounted for a significant portion of the total effect of sleep apnea and snoring on type 2 diabetes.
Review
Pharmacology & Pharmacy
Zaman Mirzadeh, Chelsea L. Faber, Michael W. Schwartz
Summary: This article explores the role of the central nervous system in glucose homeostasis and presents an integrative model in which the CNS, together with the islet, regulates blood glucose levels. The article emphasizes the importance of this model in understanding both normal glucose homeostasis and the pathogenesis of type 2 diabetes, and highlights centrally targeted therapeutic approaches.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Patrick E. MacDonald
Review
Cell Biology
Victoria L. Tokarz, Patrick E. MacDonald, Amira Klip
JOURNAL OF CELL BIOLOGY
(2018)
Article
Genetics & Heredity
Soren K. Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J. Payne, Mahesh M. Umapathysivam, Aliya F. Spigelman, Amy Barrett, Christopher J. Groves, Nicola L. Beer, Jocelyn E. Manning Fox, Mark I. McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E. MacDonald, Anna L. Gloyn
Review
Endocrinology & Metabolism
Rafael e Drigo, Birbickram Roy, Patrick E. MacDonald
Article
Endocrinology & Metabolism
Marko Gosak, Richard Yan-Do, Haopeng Lin, Patrick E. MacDonald, Andraz Stozer
Summary: Pancreatic islets show synchronized calcium oscillations and waves, which are glucose-dependent. Higher glucose levels enhance the activity and proportion of global calcium waves in the islets, leading to denser and less fragmented functional networks. Hub regions play important roles in stimulatory conditions and the roles of initiators and hubs do not overlap. In type 2 diabetes, the islets show reduced activity, locally restricted waves, and more segregated networks.
Article
Biochemistry & Molecular Biology
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J. Perone, Robert Bucki, Per Marten Hagglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Summary: Apart from known functions, such as chaperoning and disulfide bond formation, the complete molecular sequence of proinsulin folding remains unclear. In this study, we investigated the role of FKBP2, an ER-resident proline isomerase, in proinsulin folding. Through experiments and analysis, we found that FKBP2 depletion resulted in misfolding of proinsulin and increased apoptosis in pancreatic beta-cells. Additionally, we observed an overexpression of FKBP2 mRNA in beta-cells from pancreatic islets of type 2 diabetes patients. These findings suggest that FKBP2 plays a crucial role in the correct folding of proinsulin.
Article
Physiology
Mourad Ferdaoussi, Nancy Smith, Haopeng Lin, Austin Bautista, Aliya F. Spigelman, James Lyon, XiaoQing Dai, Jocelyn E. Manning Fox, Patrick E. MacDonald
PHYSIOLOGICAL REPORTS
(2020)
Article
Physiology
Shara Khan, Mourad Ferdaoussi, Austin Bautista, Valerie Bergeron, Nancy Smith, Vincent Poitout, Patrick E. MacDonald
PHYSIOLOGICAL REPORTS
(2019)
Article
Medicine, Research & Experimental
Megan E. Capozzi, Berit Svendsen, Sara E. Encisco, Sophie L. Lewandowski, Mackenzie D. Martin, Haopeng Lin, Justin L. Jaffe, Reilly W. Coch, Jonathan M. Haldeman, Patrick E. MacDonald, Matthew J. Merrins, David A. D'Alessio, Jonathan E. Campbell
Article
Medicine, Research & Experimental
Nathaniel J. Hart, Radhika Aramandla, Gregory Poffenberger, Cody Fayolle, Ariel H. Thames, Austin Bautista, Aliya F. Spigelman, Jenny Aurielle B. Babon, Megan E. DeNicola, Prasanna K. Dadi, William S. Bush, Appakalai N. Balamurugan, Marcela Brissova, Chunhua Dai, Nripesh Prasad, Rita Bottino, David A. Jacobson, Mitchell L. Drumm, Sally C. Kent, Patrick E. MacDonald, Alvin C. Powers
Review
Endocrinology & Metabolism
Mette V. Jensen, Jessica R. Gooding, Mourad Ferdaoussi, Xiao-Qing Dai, Brett S. Peterson, Patrick E. MacDonald, Christopher B. Newgard
DIABETES OBESITY & METABOLISM
(2017)
Article
Endocrinology & Metabolism
Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald
Article
Endocrinology & Metabolism
Hannah M. Gordon, Neil Majithia, Patrick E. MacDonald, Jocelyn E. Manning Fox, Poonam R. Sharma, Frances L. Byrne, Kyle L. Hoehn, Carmella Evans-Molina, Linda Langman, Kenneth L. Brayman, Craig S. Nunemaker
Article
Cell Biology
Michaela Aichler, Daniela Borgmann, Jan Krumsiek, Achim Buck, Patrick E. MacDonald, Jocelyn E. Manning Fox, James Lyon, Peter E. Light, Susanne Keipert, Martin Jastroch, Annette Feuchtinger, Nikola S. Mueller, Na Sun, Andrew Palmer, Theodore Alexandrov, Martin Hrabe de Angelis, Susanne Neschen, Matthias H. Tschop, Axel Walch