Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions

New molecular therapies for hepatocellular carcinoma

(2015) S. Torrecilla et al.   Clinics and Research in Hepatology and Gastroenterology

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

Network Modeling of TGF  Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

(2014) S. N. Steinway et al.   CANCER RESEARCH

Hepatocellular Carcinoma: Reasons for Phase III Failure and Novel Perspectives on Trial Design

(2014) J. M. Llovet et al.   CLINICAL CANCER RESEARCH

Phosphorylation of Smad2/3 at Specific Linker Threonine Indicates Slow-Cycling Intestinal Stem-Like Cells Before Reentry to Cell Cycle

(2014) Masanobu Kishimoto et al.   DIGESTIVE DISEASES AND SCIENCES

A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

(2014) Joan Fernando et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte

(2014) Carla Cicchini et al.   LIVER INTERNATIONAL

Prognostic Significance of E-Cadherin Expression in Hepatocellular Carcinoma: A Meta-Analysis

(2014) Jiang Chen et al.   PLoS One

Evidence for and against epithelial-to-mesenchymal transition in the liver

(2013) Guanhua Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reversible phospho-Smad3 signalling between tumour suppression and fibrocarcinogenesis in chronic hepatitis B infection

(2013) Y.-R. Deng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Smad phospho-isoforms direct context-dependent TGF-β signaling

(2013) Koichi Matsuzaki   CYTOKINE & GROWTH FACTOR REVIEWS

Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C

(2013) Takashi Yamaguchi et al.   HEPATOLOGY RESEARCH

Smoothened is a master regulator of adult liver repair

(2013) Gregory A. Michelotti et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib

(2012) A. Lachenmayer et al.   CLINICAL CANCER RESEARCH

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development

(2012) Kun Wu et al.   HEPATOLOGY

Col1A1 Production and Apoptotic Resistance in TGF-β1-Induced Epithelial-to-Mesenchymal Transition-Like Phenotype of 603B Cells

(2012) Jun Liu et al.   PLoS One

Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

(2012) H. Miyoshi et al.   SCIENCE

Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries

(2012) Katsunori Yoshida et al.   Frontiers in Physiology

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Smad phosphoisoform signaling specificity: the right place at the right time

(2011) Koichi Matsuzaki   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells

(2011) Koichi Matsuzaki   CELL AND TISSUE RESEARCH

The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis

(2011) Toshiro Fukui et al.   JOURNAL OF GASTROENTEROLOGY

Epithelial–mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death?

(2011) Massimo Pinzani   JOURNAL OF HEPATOLOGY

c-Jun N-Terminal Kinase 1 Promotes Transforming Growth Factor–β1–Induced Epithelial-to-Mesenchymal Transition via Control of Linker Phosphorylation and Transcriptional Activity of Smad3

(2010) Jos L. J. van der Velden et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice

(2010) David Scholten et al.   GASTROENTEROLOGY

The TAK1–TRAF6 signalling pathway

(2010) Marene Landström   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Snail1 suppresses TGF- -induced apoptosis and is sufficient to trigger EMT in hepatocytes

(2010) D. L. Franco et al.   JOURNAL OF CELL SCIENCE

Smad2 and Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions Transmit Malignant TGF-β Signal in Later Stages of Human Colorectal Cancer

(2009) Koichi Matsuzaki et al.   CANCER RESEARCH

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

(2009) Johannes Kluwe et al.   GASTROENTEROLOGY

Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-β signaling from tumor suppression to oncogenesis in early chronic hepatitis B

(2009) Miki Murata et al.   HEPATOLOGY

The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin-13 as driving forces in fibrogenesis

(2009) Hong-Lei Weng et al.   HEPATOLOGY

Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma

(2009) Hiromitsu Nagata et al.   HEPATOLOGY

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats

(2009) Ping-Fang Hu et al.   JOURNAL OF HEPATOLOGY

Mesenchymal–epithelial transition in epithelial response to injury: the role of Foxc2

(2009) C Hader et al.   ONCOGENE

TGFβ in Cancer

(2008) Joan Massagué   CELL

Phospho-control of TGF-β superfamily signaling

(2008) Katharine H Wrighton et al.   CELL RESEARCH

Roles of TGF-β family signaling in stem cell renewal and differentiation

(2008) Tetsuro Watabe et al.   CELL RESEARCH

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways

(2008) Takashi Nitta et al.   HEPATOLOGY

Molecular targeted therapies in hepatocellular carcinoma

(2008) Josep M. Llovet et al.   HEPATOLOGY

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Transitions between epithelial and mesenchymal states in development and disease

(2008) Buzz Baum et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY