Article
Food Science & Technology
Guliang Yang, Jianfeng Zhan, Yiwen Yang, Li Yuan, Peilei Wang, Chi-Tang Ho, Shiming Li
Summary: The study found that oxyresveratrol has a protective effect against liver fibrosis in rats by reducing oxidative damage and regulating gene expression, showing better efficacy than resveratrol. This may be attributed to the extra hydroxyl group at the 2-position on oxyresveratrol, making it more susceptible to oxidation.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Integrative & Complementary Medicine
Kang Rong, Tian Wen, Cao Wei, Sun Yang, Zhang Hui-Nan, Feng Ying-Da, Li Chen, Li Ze-Zhi, Li Xiao-Qiang
Summary: LF delays liver fibrosis formation, decreases AST, ALT activities, and increases Alb activity in serum. It reduces oxidative damage, suppresses the TGF-beta/Smad signaling pathway, and plays a role in attenuating CCl4-induced liver fibrosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Plant Sciences
Chaojie Chen, Jiajun Chen, Ying Wang, Liu Fang, Cuiling Guo, Tingting Sang, He Peng, Qian Zhao, Shengjia Chen, Xiaojian Lin, Xingya Wang
Summary: This study provides the first evidence that Ganoderma lucidum polysaccharide (GLP) could be a promising dietary strategy for treating liver fibrosis, which protects against liver fibrosis and hepatic stellate cell (HSC) activation through targeting inflammation, apoptosis, cell cycle, and extracellular matrix-receptor interactions mediated by the TGF-beta/Smad signaling pathway.
Article
Oncology
Yabing Guo, Geng Tian, Xin Chen, Yingjian Hou, Xinyu Zhang, Xin Xue, Li Zhao, Yun Wu
Summary: This study aimed to investigate the protective effect and mechanism of flavonoid compound GL-V9 on CCl4-induced and DDC-induced liver fibrosis. Treatment with GL-V9 alleviated hepatic injury and exhibited a significant protective effect on liver fibrosis. Further experiments demonstrated that GL-V9 treatment inhibited extracellular matrix (ECM) expression and the activation of hepatic stellate cells (HSCs) through the TGF-O/Smad pathway.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Immunology
Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu
Summary: Hepatic fibrosis is a stage of chronic liver disease that can lead to cirrhosis or liver cancer. The activation of hepatic stellate cells (HSCs) is a crucial event in fibrosis development and inhibiting this activation has been shown to alleviate fibrosis. Roxarsone, an organoarsenic additive used in livestock production, has been found to inhibit HSC activation and improve liver function in a mouse model of fibrosis. These findings suggest that Roxarsone could be a potential treatment for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Li-Li Ren, Xiao-Jun Li, Ting-Ting Duan, Zheng-Hai Li, Jun-Zheng Yang, Ya-Mei Zhang, Liang Zou, Hua Miao, Ying-Yong Zhao
Summary: Fibrosis is the excessive deposition of extracellular matrix components in the processes of tissue repair, causing organ structural integrity and functional impairment. Transforming growth factor-beta (TGF-beta) is a key factor in promoting fibrosis by activating profibrotic signals. This review discusses the role of TGF-beta signaling in fibrotic organs, as well as potential therapeutic options for targeting tissue fibrosis through modulating TGF-beta signaling.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Guang-Hao Zheng, Jian Liu, Fang Yan Guo, Zhi-Hong Zhang, Yin-Jing Jiang, Yong-Ce Lin, Xiao-Qi Lan, Jie Ren, Yan-Ling Wu, Ji-Xing Nan, Cheng Hua Jin, Li-Hua Lian
Summary: In this study, a new drug J-1063 was synthesized and its anti-fibrotic activity was evaluated. The results showed that J-1063 had significant inhibitory effects on liver fibrosis, possibly by inhibiting TGF-beta-Smad signaling.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Yunqi Yao, Zhemin Xia, Fuyi Cheng, Qingyuan Jang, Jiao He, Cheng Pan, Lin Zhang, Yixin Ye, Yuan Wang, Shuang Chen, Dongsheng Su, Xiaolan Su, Lin Cheng, Gang Shi, Lei Dai, Hongxin Deng
Summary: Human placental mesenchymal stem cells (hPMSCs) can effectively alleviate experimental hepatic fibrosis, inhibit inflammation, and show better therapeutic effects against mild-to-moderate LF. hPMSCs downregulate fibrosis-related genes, promote the upregulation of Cav1, leading to inhibition of activated HSCs and suppression of the TGF-beta/Smad signaling pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Article
Food Science & Technology
Jianfeng Zhan, Ting Hu, Junfeng Shen, Guliang Yang, Chi-Tang Ho, Shiming Li
Summary: This study evaluated the anti-hepatic fibrosis effects of pterostilbene compared to two hydroxylated stilbene compounds. The results demonstrated that stilbenes had significant protective effects against rat liver fibrosis, with pterostilbene showing more potent preventive activity than the hydroxylated stilbenes.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Guangwen Shu, Chenxi Dai, Arslan Yusuf, Hui Sun, Xukun Deng
Summary: Limonin inhibits TGF-beta-induced EMT of hepatocytes and activation of HSCs in vitro and alleviates mouse CCl4-induced liver fibrosis by upregulating Smad7.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Amr M. Abdelhamid, Ayman Selim, Mai A. Zaafan
Summary: Liver fibrosis is characterized by the activation of hepatic stellate cells into myofibroblasts, which is triggered by specific signaling pathways. Piperine has shown promising potential as an anti-fibrotic agent through modulation of TGF-beta 1/Smad pathway. The study evaluated the beneficial effects of piperine in liver fibrosis through modulation of miRNA-17 and TGF-beta/smads pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Terunao Iwanaga, Tetsuhiro Chiba, Masato Nakamura, Tatsuya Kaneko, Junjie Ao, Na Qiang, Yaojia Ma, Jiaqi Zhang, Tadayoshi Kogure, Sae Yumita, Takamasa Ishino, Keita Ogawa, Motoyasu Kan, Miyuki Nakagawa, Kisako Fujiwara, Naoto Fujita, Takafumi Sakuma, Hiroaki Kanzaki, Keisuke Koroki, Yuko Kusakabe, Masanori Inoue, Kazufumi Kobayashi, Naoya Kanogawa, Soichiro Kiyono, Takayuki Kondo, Ryo Nakagawa, Sadahisa Ogasawara, Shingo Nakamoto, Ryosuke Muroyama, Jun Kato, Tatsuo Kanda, Hitoshi Maruyama, Naoya Mimura, Takuya Honda, Toshihiko Murayama, Hiroyuki Nakamura, Naoya Kato
Summary: This study demonstrates that miglustat can suppress liver fibrosis by inhibiting the TGF-5/Smad pathway, reducing the expression of extracellular matrix components such as collagen. The research also shows that miglustat can both prevent the occurrence of liver fibrosis and reverse established fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yufeng Yao, Yuanyuan Chen, Dawa Zeren, Yunxia Ma, Yuanyuan Xie, Qian Wang, Huanhuan Ma, Meiqi Wang, Fangle Liu, Chenchen Zhu, Chaozhan Lin
Summary: This study investigated the anti-fibrotic effects of five major components from Delphinium trichophorum on fibroblasts for the first time. The results showed that all five compounds could effectively reduce abnormal proliferation of fibroblasts and decrease collagen production. Among them, DTF1 and DTF2 demonstrated superior effectiveness. Further experiments revealed that DTF1 and DTF2 exerted their effects by inhibiting the activation of the TGF-β1/Smad signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Xiongqun Peng, Huixiang Yang, Lijian Tao, Jingni Xiao, Ya Zeng, Yueming Shen, Xueke Yu, Fei Zhu, Jiao Qin
Summary: This study investigated the therapeutic effect of the antifibrotic drug fluorofenidone on liver fibrosis and its mechanism. The results showed that fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the involvement of SMAD2/SMAD3 and autophagy.