Article
Immunology
Chunbo Li, Keqin Hua
Summary: This study used single-cell RNA sequencing to describe the composition and functional status of immune cells and mesenchymal cells during cervical cancer progression. The results showed distinct cell subpopulations at different stages of cervical cancer, with high-grade intraepithelial neoplasia exhibiting a low, recently activated tumor microenvironment, tumor tissue displaying an immunosuppressive state, and metastatic lymph node showing an early activated phase of immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Guang-Li Zhu, Xiao-Min Zhang, Kai-Bin Yang, Ling-Long Tang, Jun Ma
Summary: This study investigated the metastatic patterns of level II-V lymph nodes in nasopharyngeal carcinoma (NPC) patients using vertebrae as anatomical landmarks. It was found that the metastasis rate gradually decreased from higher vertebral levels to lower levels. The study suggests that the clinical target volume in radiotherapy can be reduced to two vertebral levels below the metastatic level II-V nodes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Hayato Tomita, Tsuneo Yamashiro, Joichi Heianna, Toshiyuki Nakasone, Tatsuaki Kobayashi, Sono Mishiro, Daisuke Hirahara, Eichi Takaya, Hidefumi Mimura, Sadayuki Murayama, Yasuyuki Kobayashi
Summary: This study demonstrated that deep learning analysis of pretreatment contrast-enhanced CT can provide better diagnostic performance in differentiating between benign and metastatic cervical lymph nodes in patients with oral squamous cell carcinoma, compared to radiologists' assessments alone.
Article
Endocrinology & Metabolism
Lin Yan, Ying Zhang, Bo Jiang, Yukun Luo
Summary: This study evaluated the safety and efficacy of radiofrequency ablation (RFA) for metastatic lymph nodes (LNs) in children and adolescents with papillary Thyroid Carcinoma (PTC). The results showed that RFA may provide another less invasive and effective alternative for the existing therapeutic modalities for cervical metastatic LNs in children and adolescents with PTC.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medical Laboratory Technology
Samuel Bidot, Ashley Monsrud, Meredith Kline, Alexandra Speak, Dylan Martini, Mehmet A. Bilen, Jeffrey M. Switchenko, Yuzi Zhang, Amany Ghaly Gerges, Ghada N. Farhat, Edward A. Dent, Viraj A. Master, Mazie L. Tinsley, Lara R. Harik
Summary: This study found that pN1 prostate adenocarcinoma patients with >= 2 positive regional lymph nodes are three times more likely to have an unfavorable outcome. These results suggest that further stratifying lymph node metastasis in prostate adenocarcinoma patients into risk categories could help tailor individualized follow-up and therapy.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Obstetrics & Gynecology
Koray Aslan, Ali Haberal, Huseyin Akilli, Mehmet Mutlu Meydanli, Ali Ayhan
Summary: The number of metastatic lymph nodes has different prognostic values in squamous and non-squamous histologies among women with node-positive cervical cancer. Higher number of mLNs is associated with worse survival outcomes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Endocrinology & Metabolism
Leonardo Barbi Walter, Rafael Selbach Scheffel, Andre Borsatto Zanella, Mauricio Farenzena, Carlo Sasso Faccin, Marcia Silveira Graudenz, Jose Miguel Dora, Ana Luiza Maia
Summary: In this study, we evaluated the outcomes of active surveillance (AS) for metastatic cervical lymph nodes in differentiated thyroid cancer (DTC) patients. The results showed that most small metastatic cervical lymph nodes remained stable and could be safely managed with AS.
Article
Oncology
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Summary: This study evaluated clinical strategies based on sonographic features of lymph nodes and found that detecting malignant lymph nodes through FNAC or elevated FNA-Tg had a high malignancy rate, while stratification based on sonographic features was necessary for nodes with indeterminate or benign results. A diagnostic algorithm combining FNAC, FNA-Tg, and ultrasound features was proposed for diagnosing metastatic lymph nodes of differentiated thyroid carcinomas.
Article
Chemistry, Multidisciplinary
Zenghui Wang, Heming Xia, Binlong Chen, Yaoqi Wang, Qingqing Yin, Yue Yan, Ye Yang, Mingmei Tang, Jianxiong Liu, Ruiyang Zhao, Wenzhe Li, Qiang Zhang, Yiguang Wang
Summary: A novel type of near-infrared nanoparticles integrating chemiluminescence technology and signal amplification strategy has been developed for accurate identification of metastatic sentinel lymph nodes in animal tumor models, showing excellent imaging capability for early detection.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medical Laboratory Technology
Arash H. Lahouti, Saeed Asiry, Ellen J. Giampoli
Summary: This article presents a case of pituitary carcinoma and emphasizes its key cytomorphologic features and differential diagnosis.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Review
Endocrinology & Metabolism
Wanqing Tang, Xiuyun Tang, Danni Jiang, Xiaojuan Zhang, Rongling Wang, Xiaoyan Niu, Yichen Zang, Mingzhu Zhang, Xinya Wang, Cheng Zhao
Summary: This study evaluated the safety and efficacy of radiofrequency ablation (RFA), microwave ablation (MWA), and laser ablation (LA) for the treatment of cervical metastatic lymph nodes (CMLNs) of papillary thyroid carcinoma (PTC). The results showed that all thermal ablations were safe and effective for the treatment of CMLNs of PTC, but there were differences in efficacy among different treatment modalities, with MWA being the most effective and LA being the least effective.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Qiyue Wang, Zhuo Tan, Chuanming Zheng, Jiafeng Wang, Guowan Zheng, Ping Huang, Yiwen Zhang, Minghua Ge
Summary: This study aimed to investigate the predictive value of NPLN, LODDS, and pLNR in prognosis of larynx squamous cell carcinoma and establish an optimal prognostic model. The results showed that the combined model of NPLN and LODDS had the best predictive performance and was more accurate than the 7th AJCC TNM stage.
Article
Oncology
Yiliang Zhang, Longfu Zhang, Bin Li, Ting Ye, Yang Zhang, Yongfu Yu, Yuan Ma, Yihua Sun, Jiaqing Xiang, Yike Li, Haiquan Chen
Summary: This study applied machine learning to predict the metastasis of recurrent laryngeal nerve (RLN) lymph nodes in esophageal squamous cell carcinoma (ESCC). Models were established using baseline and pathological features of 3352 surgically treated ESCC patients, achieving high negative predictive values and suggesting potential intraoperative applications to spare RLN node dissection.
Article
Endocrinology & Metabolism
Caigu Yan, Xianghui He, Zuoyu Chen, Yizeng Wang
Summary: A nomogram was constructed to evaluate the patterns of central compartment lymph node metastasis (CLNM) in different age groups of papillary thyroid carcinoma (PTC). The study identified independent risk factors for CLNM through multivariate logistic regression analysis. The results showed that there are different CLNM risk factors in patients of different age groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Jossie Rotman, A. Marijne Heeren, Awa A. Gassama, Sinead M. Lougheed, Noelle Pocorni, Anita G. M. Stam, Maaike C. G. Bleeker, Henry J. M. A. A. Zijlmans, Constantijne H. Mom, Gemma G. Kenter, Ekaterina S. Jordanova, Tanja D. de Gruijl
CLINICAL CANCER RESEARCH
(2020)
Article
Infectious Diseases
F. J. Vink, B. Lissenberg-Witte, C. J. L. M. Meijer, J. Berkhof, F. J. van Kemenade, A. G. Siebers, R. D. M. Steenbergen, M. C. G. Bleeker, D. A. M. Heideman
Summary: The study found that FAM19A4/miR124-2 methylation analysis has good sensitivity and long-term risk prediction ability in HPV-based cervical screening, making it a good alternative to cytology.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Pathology
Wieke W. Kremer, Frederique J. Vink, Marjolein van Zummeren, Greta Dreyer, Lawrence Rozendaal, John Doorbar, Maaike C. G. Bleeker, Chris J. L. M. Meijer
Review
Genetics & Heredity
Rianne van den Helder, Birgit M. M. Wever, Jip A. van Trommel, Johannes C. F. Ket, Maaike C. G. Bleeker, Renske D. M. Steenbergen, Nienke E. van Trommel
Article
Genetics & Heredity
Stefanie Dick, Lisanne Verhoef, Lise M. A. De Strooper, Iuliana Ciocanea-Teodorescu, G. Bea A. Wisman, Chris J. L. M. Meijer, Maaike C. G. Bleeker, Renske D. M. Steenbergen, Danielle A. M. Heideman
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Chris J. L. M. Meijer, Willem J. G. Melchers, Ruud L. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert J. van Kemenade, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study validated individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 for the detection of CIN3+ in high-risk HPV-positive women invited for routine screening, showing promising clinical utility.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Anne Marijne Heeren, Jossie Rotman, Sanne Samuels, Henry J. M. A. A. Zijlmans, Guus Fons, Koen K. van de Vijver, Maaike C. G. Bleeker, Gemma G. Kenter, Ekaterina J. Jordanova, Tanja D. de Gruijl
Summary: Metastatic spread in vulvar tumor-draining lymph nodes is characterized by an inflamed microenvironment with activated effector T cells, potentially suppressed by inhibitory feedback mechanisms. Targeted therapeutic interventions based on CTLA-4 and PD-1 blockade are recommended to reinvigorate memory T cells and inhibit early metastatic spread and growth.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Feline O. Voss, Nikki B. Thuijs, Ravi F. M. Vermeulen, Erica A. Wilthagen, Marc van Beurden, Maaike C. G. Bleeker
Summary: Patients with differentiated vulvar intraepithelial neoplasia have a high risk of developing vulvar squamous cell carcinoma, with rapid cancer progression. Increased awareness, timely recognition, aggressive treatment, and close follow-up are strongly recommended for HPV-independent vulvar conditions including dVIN.
Article
Oncology
Mario Preti, Elmar Joura, Pedro Vieira-Baptista, Marc Van Beurden, Federica Bevilacqua, Maaike C. G. Bleeker, Jacob Bornstein, Xavier Carcopino, Cyrus Chargari, Margaret E. Cruickshank, Bilal Emre Erzeneoglu, Niccolo Gallio, Debra Heller, Vesna Kesic, Olaf Reich, Colleen K. Stockdale, Bilal Esat Temiz, Linn Woelber, Francois Planchamp, Jana Zodzika, Denis Querleu, Murat Gultekin
Summary: The European societies have developed consensus statements on pre-invasive vulvar lesions to improve patient care. The treatment methods vary depending on the type of lesion, including excisional procedures, ablative procedures, and medical treatment. Regular follow-up and assessment are necessary after treatment.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Biochemistry & Molecular Biology
Marissa J. Harmsen, Arda Arduc, Maaike C. G. Bleeker, Lynda J. M. Juffermans, Arjan W. Griffioen, Ekaterina S. Jordanova, Judith A. F. Huirne
Summary: Evidence suggests that adenomyosis patients have increased angiogenesis and lymphangiogenesis in both ectopic and eutopic endometrium. This finding indicates a potential link between adenomyosis and blood vessel and lymph vessel formation in the endometrium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Feline O. Voss, Nikki B. Thuijs, Sylvia Duin, Mujde Ozer, Marc van Beurden, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study aimed to validate the accuracy of previously identified DNA methylation markers for detection of high-grade vulvar intraepithelial neoplasia (VIN). The best-performing individual marker was found to be SST, detecting 80% of high-grade VIN cases, with excellent detection of HPV-independent VIN, known to have the highest cancer risk. Selection of a marker panel including ZNF582, SST, and miR124-2 also yielded high accuracy for detection of high-grade VIN.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Nikki B. Thuijs, Marc van Beurden, Sylvia Duin, Danielle A. M. Heideman, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study comprehensively classified and assessed a large series of vulvar lesions, finding that 88.4% of high-grade VIN were associated with HPV and 10.9% were HPV independent. Immunohistochemistry testing for p16INK4a and p53 is important for distinguishing between the two types, which have different cancer risks.
Article
Oncology
Laure Nicolai, Refika Yigit, Maaike C. G. Bleeker, Joost Bart, Jacobus van der Velden, Constantijne H. Mom
Summary: For patients with stage IA cervical cancer with a diameter >7 mm, we recommend considering a pelvic lymph node assessment in case of DOI >3 mm and/or presence of LVSI.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Immunology
Tofan Widya Utami, Andrijono Andrijono, Andi Putra, Junita Indarti, Gert Fleuren, Ekaterina Jordanova, Inas Humairah, Ahmad Utomo
Summary: This study aims to explore the HPV genotype distribution in women with clinically normal cervix. The most frequently detected HPV genotype is HPV 52, and the highest HPV infections occur in women aged 31-40 and 41-50. Screening is recommended for women aged 31-50, and a different nonavalent formula for HPV vaccines might be useful for the Indonesian population.
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2022)
Article
Virology
Rianne van den Helder, Nienke E. van Trommel, Annina P. van Splunter, Birgit Lissenberg-Witte, Maaike C. G. Bleeker, Renske D. M. Steenbergen
PAPILLOMAVIRUS RESEARCH
(2020)