Elucidation of first step of the allylmalonyl-CoA biosynthetic pathway by expression of heterologous KSIII gene and enhancement of 36-methyl-FK506 production by genetic and chemical engineering

Overexpression of the putative extracytoplasmic function sigma (σ) factor FujE enhances FK506 production in Streptomyces sp. strain KCCM 11116P

(2014) Sung-Kwon Lee et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer ‘Streptomyces tsukubaensis’

(2012) Miriam Martínez-Castro et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011

(2012) SangJoon Mo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Tacrolimus in transplant rejection

(2012) Thomas Rath   EXPERT OPINION ON PHARMACOTHERAPY

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway Engineering

(2012) Anna Lechner et al.   ACS Synthetic Biology

Unusual carbon fixation gives rise to diverse polyketide extender units

(2011) Nick Quade et al.   Nature Chemical Biology

Innovative Use of Topical Calcineurin Inhibitors

(2010) Andrew N. Lin   DERMATOLOGIC CLINICS

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Liquid chromatography–mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP

(2009) Je Won Park et al.   ANALYTICAL BIOCHEMISTRY

Long-term safety of tacrolimus ointment in atopic dermatitis

(2009) Anita Remitz et al.   Expert Opinion On Drug Safety

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

(2009) Yuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA