Genotype-Phenotype Effects of Bmpr2 Mutations on Disease Severity in Mouse Models of Pulmonary Hypertension

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

(2016) Sudakshina Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Characteristics of Pulmonary Arterial Hypertension in Affected Carriers of a Mutation Located in the Cytoplasmic Tail of Bone Morphogenetic Protein Receptor Type 2

(2015) Barbara Girerd et al.   CHEST

Defective cellular trafficking of the bone morphogenetic protein receptor type II by mutations underlying familial pulmonary arterial hypertension

(2015) Anne John et al.   GENE

Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects

(2015) Rajiv D. Machado et al.   HUMAN MUTATION

Regulation of eNOS Enzyme Activity by Posttranslational Modification

(2014) Elke Heiss et al.   CURRENT PHARMACEUTICAL DESIGN

Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2014) Allison R. Prewitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sugen 5416/Hypoxia Mouse Model of Pulmonary Hypertension Revisited: Long-Term Follow-Up

(2014) Sally H. Vitali et al.   Pulmonary Circulation

Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

(2013) Loredana Ciuclan et al.   AMERICAN JOURNAL OF PATHOLOGY

Imatinib Attenuates Hypoxia-induced Pulmonary Arterial Hypertension Pathology via Reduction in 5-Hydroxytryptamine through Inhibition of Tryptophan Hydroxylase 1 Expression

(2013) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary arterial hypertension

(2013) David Montani et al.   Orphanet Journal of Rare Diseases

Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

(2013) Andrea L. Frump et al.   PLoS One

Analysis of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice

(2013) Shivendra G. Tewari et al.   Frontiers in Physiology

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

(2013) Jin Qian et al.   Frontiers in Physiology

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

(2012) Jose Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Longitudinal Analysis Casts Doubt on the Presence of Genetic Anticipation in Heritable Pulmonary Arterial Hypertension

(2012) Emma K. Larkin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Connectivity Map Analysis of Nonsense-Mediated Decay–PositiveBMPR2-Related Hereditary Pulmonary Arterial Hypertension Provides Insights into Disease Penetrance

(2012) Charles Flynn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension

(2012) Kevin White et al.   CIRCULATION

BMPR2 Mutations Influence Phenotype More Obviously in Male Patients With Pulmonary Arterial Hypertension

(2012) Dong Liu et al.   Circulation-Cardiovascular Genetics

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Allergic Inflammation Causes Vascular Remodeling and Pulmonary Hypertension in Bmpr2 Hypomorph and Wild-Type Mice

(2012) Elizabeth M. Mushaben et al.   PLoS One

Sense from nonsense: therapies for premature stop codon diseases

(2012) Laure Bidou et al.   TRENDS IN MOLECULAR MEDICINE

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular genetics and clinical features of Chinese idiopathic and heritable pulmonary arterial hypertension patients

(2011) D. Liu et al.   EUROPEAN RESPIRATORY JOURNAL

Bone Morphogenetic Protein Receptor II Is a Novel Mediator of Endothelial Nitric-oxide Synthase Activation

(2011) Archana Gangopahyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

BMP signaling in vascular development and disease

(2010) Jonathan W. Lowery et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

(2009) Lynda Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice

(2008) Yanli Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Clinical Outcomes of Pulmonary Arterial Hypertension in Carriers ofBMPR2Mutation

(2008) Benjamin Sztrymf et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MURINE PULMONARY RESPONSE TO CHRONIC HYPOXIA IS STRAIN SPECIFIC

(2008) Yuji Tada et al.   EXPERIMENTAL LUNG RESEARCH

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

(2008) A. Sobolewski et al.   HUMAN MOLECULAR GENETICS

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

(2007) David B. Frank et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY