Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells

Structure and functional roles of Epac2 (Rapgef4)

(2016) Kenji Sugawara et al.   GENE

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

(2016) Nicole Gallo-Payet   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Signal transduction in the hypothalamic corticotropin-releasing factor system and its clinical implications

(2016) Kazunori Kageyama et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention

(2015) Muayad Almahariq et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics

(2015) Upasana Banerjee et al.   GENE

The future of EPAC-targeted therapies: agonism versus antagonism

(2015) Euan Parnell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses

(2014) Satoshi Okumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca 2+ Leak and Arrhythmia

(2013) Laëtitia Pereira et al.   CIRCULATION

Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A

(2013) Woo-Jin Song et al.   DIABETES

Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome

(2013) Alan K. L. Kai et al.   FASEB JOURNAL

DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

(2013) Erling A. Hoivik et al.   PLoS One

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Social, Communication, and Cortical Structural Impairments in Epac2-Deficient Mice

(2012) D. P. Srivastava et al.   JOURNAL OF NEUROSCIENCE

Regulation of adrenocortical steroid hormone production by RhoA–diaphanous 1 signaling and the cytoskeleton

(2012) Marion B. Sewer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis

(2012) Leeyah Issop et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

(2012) S. V. Consonni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of a Cyclic Amp-Guanine Exchange Factor in Hepatocytes Decreases Nitric Oxide Synthase Expression

(2012) Baochun Zhang et al.   SHOCK

Cyclic AMP dynamics in the pancreatic β-cell

(2012) Anders Tengholm   UPSALA JOURNAL OF MEDICAL SCIENCES

Molecular determinants and feedback circuits regulating type 2 CRH receptor signal integration

(2011) Danijela Markovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Induction of Leptin Resistance by Activation of cAMP-Epac Signaling

(2011) Makoto Fukuda et al.   Cell Metabolism

Early steps in steroidogenesis: intracellular cholesterol trafficking

(2011) Walter L. Miller et al.   JOURNAL OF LIPID RESEARCH

Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway

(2011) D. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism

(2010) E. Baljinnyam et al.   CANCER RESEARCH

Ion Channels and Signaling in the Pituitary Gland

(2010) Stanko S. Stojilkovic et al.   ENDOCRINE REVIEWS

Functional Roles of Protein Kinase A (PKA) and Exchange Protein Directly Activated by 3′,5′-Cyclic Adenosine 5′-Monophosphate (cAMP) 2 (EPAC2) in cAMP-Mediated Actions in Adrenocortical Cells

(2010) Linda Aumo et al.   ENDOCRINOLOGY

Epac2-mediated dendritic spine remodeling: Implications for disease

(2010) Peter Penzes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression

(2009) Richard L. Hauger et al.   Annals of the New York Academy of Sciences

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

(2009) Maria Grandoch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulatory Mechanisms Underlying Corticotropin-Releasing Factor Gene Expression in the Hypothalam

(2009) Kazunori KAGEYAMA et al.   ENDOCRINE JOURNAL

Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval

(2009) Anghelus Ostroveanu et al.   HIPPOCAMPUS

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

(2009) Manabu Niimura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

(2009) Kevin M Woolfrey et al.   NATURE NEUROSCIENCE

Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2

(2009) Kristof Van Kolen et al.   NEUROPHARMACOLOGY

Metabolites of an Epac-Selective cAMP Analog Induce Cortisol Synthesis by Adrenocortical Cells through a cAMP-Independent Pathway

(2009) Judith A. Enyeart et al.   PLoS One

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

(2009) C.-L. Zhang et al.   SCIENCE

PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways

(2008) Magdalena J. Lorenowicz et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems

(2008) Adrian J. Dunn et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ACTH Inhibits bTREK-1 K+Channels through Multiple cAMP-dependent Signaling Pathways

(2008) Haiyan Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Epac mediates PACAP-dependent long-term depression in the hippocampus

(2008) Jeanne Ster et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Steroid Hormone Biosynthesis by the Cytoskeleton

(2008) Marion B. Sewer et al.   LIPIDS

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

(2008) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes

(2008) R. K. Petersen et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Mechanisms of Corticotropin-Releasing Factor Receptor-Induced Calcium Signaling

(2008) E. Gutknecht et al.   MOLECULAR PHARMACOLOGY

cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector

(2008) Evanthia Aivatiadou et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE

cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

(2008) J. S. O'Neill et al.   SCIENCE