期刊
GENE
卷 575, 期 2, 页码 577-583出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2015.09.029
关键词
Epac2; cAMP; Rap
资金
- National Institutes of Health [GM089820, GM114833]
- Ministry of Education, Culture, Sport, Science and Technology, Japan [24229007]
- Grants-in-Aid for Scientific Research [25461351, 16K09749, 15K08176] Funding Source: KAKEN
Epac (exchange protein activated by cyclic-AMP) 2 is a direct target of 3'-5'-cyclic adenosine monophosphate (cAMP) and is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase Rap. Crystallographic analyses revealed that activation of Epac2 by CAMP is accompanied by dynamic structural changes. Epac2 is expressed mainly in brain, neuroendocrine and endocrine tissues, and is involved in diverse cellular functions in the tissues. In this review, we summarize the structure and function of Epac2. We also discuss the physiological and pathophysiological roles of Epac2, and the possibility of Epac2 as a therapeutic target. (C) 2015 Elsevier B.V. All rights reserved.
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