Article
Chemistry, Applied
Yurong Wei, Chengxu Gong, Min Zhao, Lei Zhang, Shaodan Yang, Peixu Li, Zhao Ding, Quan Yuan, Yanbing Yang
Summary: This review summarizes the research progress in the synthesis of lanthanide-based persistent luminescence nanoparticles (PLNPs), outlines several typical synthesis methods, discusses the advantages, drawbacks, current challenges, and potential solutions. The review aims to provide strategies for designing lanthanide-based PLNPs with desired properties and promoting their applications in biomedicine, energy, and information science.
JOURNAL OF RARE EARTHS
(2022)
Review
Chemistry, Physical
Palak Jethva, Munira Momin, Tabassum Khan, Abdelwahab Omri
Summary: This article introduces the applications of upconverting luminescent nanoparticles (UCNPs) in life sciences and healthcare, including bioimaging and drug delivery. By controlling the chemical composition and structure of UCNPs, enhanced imaging contrast, multiplexed detection, and low toxicity effects can be achieved. By surface modification and functionalization, a connection can be established between nanoparticles and biomolecules to expand the application of inorganic nanomaterials in biological environments.
Review
Chemistry, Multidisciplinary
Qiang Luo, Wenjie Wang, Jie Tan, Quan Yuan
Summary: Persistent luminescence materials (PLMs) have great potential for biological applications but require surface modification to overcome stability, selectivity, and biocompatibility issues in biological systems.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Analytical
Mingkai Wang, Chuanyu Hu, Qianqian Su
Summary: This review presents recent advances in the applications and lifetime regulation strategies of lanthanide-doped nanoparticles in bioimaging and biodetection. By modulating the core-shell structure, concentration of sensitizer and emitter, and energy transfer channels, the lifetime of nanoparticles can be regulated and applied in various biosensing applications, such as ion and molecule detection, DNA and protease detection.
Article
Chemistry, Analytical
Siqi Gao, Renbin Zhou, Soham Samanta, Junle Qu, Tymish Y. Ohulchanskyy
Summary: This review summarizes recent progress in the development of various plasmon-enhanced luminescence (PEL)-based biosensors and bioimaging platforms for diverse biological and biomedical applications. The study evaluates the performance improvement of PEL-based biosensors in efficiently detecting biomarkers (proteins and nucleic acids) in point-of-care tests and discusses the pros and cons of recently developed PEL-based biosensing platforms on substrates or in solutions. It also includes a brief discussion on integrating PEL-based biosensing platforms into microfluidic devices as a promising multi-responsive detection method. The review presents comprehensive details about the recent advances in the development of various PEL-based multi-functional (passive targeting, active targeting, and stimuli-responsive) bioimaging probes, highlighting the scope of future improvements in devising robust PEL-based nanosystems to achieve more effective diagnostic and therapeutic insights by enabling imaging-guided therapy.
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Analytical
Yong Li, Chen Chen, Fangfang Liu, Jinliang Liu
Summary: Fluctuations of intracellular ions, biomolecules, and other conditions play crucial roles in biological processes. Upconversion nanoparticles (UCNPs) show unique properties for biomedical detection. This review summarizes the synthesis, biomedical applications, and future perspectives of UCNPs.
Review
Nanoscience & Nanotechnology
Xia Sun, Liang Song, Nian Liu, Junpeng Shi, Yun Zhang
Summary: ZGC NPs, as a representative of NIR PLNPs, have drawn extensive attention in autofluorescence-free biosensing and bioimaging due to their persistent luminescence property and high chemical stability. Their potential applications in biomedical field are promising.
ACS APPLIED NANO MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Benjamin Sreenan, Bryan Lee, Li Wan, Ruosheng Zeng, Jialong Zhao, Xiaoshan Zhu
Summary: This review discusses the applications of colloidal semiconductor nanocrystals (NCs) in biosensing/imaging and the technique of time-resolved luminescence measurement. The traditional luminescence-intensity measurement suffers from autofluorescence in biological samples, limiting the sensitivities. To overcome this, the review suggests using time-resolved luminescence measurement with long-lived probes. However, the current long-lived probes have optical limitations. Therefore, developing probes with high brightness, low-energy excitation, and long lifetimes is crucial for low-cost, compact, and sensitive instruments for in-field or point-of-care testing. Mn-doped NCs offer potential solutions to these challenges.
ACS APPLIED NANO MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Beatriz B. Oliveira, Daniela Ferreira, Alexandra R. Fernandes, Pedro Viana Baptista
Summary: Advances in nanotechnology and medical science have led to the development and application of nanomaterials and nanoparticles in biomedicine. Gold nanoparticles have attracted significant interest due to their unique properties, and they hold great value for use in biodetection and diagnostics.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jun Ma, Xinyu Wang, Jian Feng, Chengzhi Huang, Zhongcai Fan
Summary: Plasmonic nanoparticles (PNPs) have excellent properties for converting stimuli into optical signals and are widely used in biological sensing and imaging. Single optical biosensors with plasmonic properties enable high-resolution imaging techniques in biological applications.
Review
Chemistry, Physical
Ruibing Feng, Guodong Li, Chung-Nga Ko, Zhang Zhang, Jian-Bo Wan, Qing-Wen Zhang
Summary: Luminescence bioimaging and biosensing in the NIR-II spectral window have great potential for target-specific imaging and noninvasive monitoring. NIR-II luminescence lifetime imaging offers advantages such as lower background noises, higher sensitivity, and higher spatial resolution, making it suitable for deep tissue imaging and biomedical applications.
Article
Nanoscience & Nanotechnology
Roxana M. Calderon-Olvera, Encarnacion Arroyo, Aaron M. Jankelow, Rashid Bashir, Enrique Valera, Manuel Ocana, Ana Isabel Becerro
Summary: This study synthesized highly uniform Mn-doped Zn2GeO4 nanoparticles using a one-pot, microwave-assisted hydrothermal method with polyacrylic acid as an additive. The nanoparticles showed good dispersibility, high chemical stability, and surface functionalization. The presence of carboxylate groups allows for the conjugation of biomolecules and the development of a persistent luminescence-based sandwich immunoassay for the detection of interleukin-6 in human serum and plasma samples.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Hong Ruan, Li Zhou
Summary: The rapid industrialization has caused serious environmental problems and increased disease and healthcare issues. The development of simple and effective biosensors is crucial for disease prevention and treatment. Sulfur quantum dots, as a new fluorescent nanomaterial, offer great potential in the fields of bioimaging and biosensing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Zhenjie Qiao, Jian Zhang, Xin Hai, Yongcun Yan, Weiling Song, Sai Bi
Summary: Metal nanoclusters (MNCs) are a promising nanomaterial composed of several to hundreds of metal atoms, with unique physical and chemical properties. Template-assisted synthesis of MNCs has gained extensive attention in the biological field due to its advantages of facile preparation, controllable size, water-solubility, and biocompatibility.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Jianhua Liu, Bruno Viana, Nathalie Mignet, Daniel Scherman, Yingshuai Liu, Cyrille Richard
Summary: This article introduces the characteristics of Persistent luminescence nanoparticles (PLNPs) and their application in detecting biomolecules. It also reports the unexpected effect of hydrogen peroxide on the signal intensity of ZnGa2O4:Cr3+ nanoparticles, which can be used to detect and quantify H2O2.
Article
Food Science & Technology
Veronica Segura, Jacobo Diaz, Angela Ruiz-Carnicer, Alba Munoz-Suano, Carolina Carrillo-Carrion, Carolina Sousa, Angel Cebolla, Isabel Comino
Summary: The new Universal Gluten Extraction Solution (UGES) shows higher extraction efficiency and safety, with reduced extraction time and wider applicability. Compared to traditional extraction solutions, UGES is more environmentally friendly, compatible with competitive ELISA.
Correction
Chemistry, Physical
Jonas Huspacing Diaeresishn, Carolina Carrillo-Carrion, Mahmoud G. Soliman, Christian Pfeiffer, Daniel Valdeperez, Atif Masood, Indranath Chakraborty, Lin Zhu, Marta Gallego, Zhao Yue, Monica Carril, Neus Feliu, Alberto Escudero, Alaaldin M. Alkilany, Beatriz Pelaz, Pablo del Pino, Wolfgang J. Parak
CHEMISTRY OF MATERIALS
(2021)
Correction
Chemistry, Inorganic & Nuclear
Alberto Escudero, Lola Gonzalez-Garcia, Robert Strahl, Dong Jin Kang, Juraj Drzic, Tobias Kraus
INORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Svetlana Rodimova, Vadim Elagin, Maria Karabut, Irina Koryakina, Alexander Timin, Vladimir Zagainov, Mikhail Zyuzin, Elena Zagaynova, Daria Kuznetsova
Summary: Finding new criteria, testing drugs for hepatotoxicity, and studying the mechanisms of hepatotoxicity at a molecular level are challenging and require adequate research models and tools. Microfluidic chips offer a promising in vitro model, but more complex models are needed for comprehensive information. FLIM is a new label-free approach for studying liver pathology.
Article
Chemistry, Inorganic & Nuclear
Juraj Drzic, Alberto Escudero, Lola Gonzalez-Garcia, Tobias Kraus
Summary: We have synthesized AgNP@PEDOT:PSS hybrid conductive particles, consisting of silver cores and polythiophene shells, for sinter-free inks used in printing electronics. By replacing the ligand shell on the metal particle surface, these particles can form stable dispersions. Ink formulations with a solid content of the hybrid particles were prepared and demonstrated their electrical conductivity without post-deposition treatment. The resulting inks showed comparable conductivity to elemental silver and gold inks.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Oncology
Irina Druzhkova, Elena Nikonova, Nadezhda Ignatova, Irina Koryakina, Mikhail Zyuzin, Artem Mozherov, Dmitriy Kozlov, Dmitry Krylov, Daria Kuznetsova, Uliyana Lisitsa, Vladislav Shcheslavskiy, Evgeny A. Shirshin, Elena Zagaynova, Marina Shirmanova
Summary: Understanding the interactions between chemotherapeutic agents and cancer cells in the presence of extracellular matrix (ECM) is crucial for improving drug delivery and treatment efficacy. This study used 3D collagen-based models to show that collagen slows down the diffusion of doxorubicin, reducing cellular drug uptake and leading to changes in cellular metabolic status. The protective role of collagen for cancer cells was observed, as it impedes drug delivery and changes cellular metabolic status, highlighting the potential for modifying ECM structure to improve chemotherapy efficacy.
Article
Nanoscience & Nanotechnology
Carolina Carrillo-Carrion, Valentine Comaills, Ana M. Visiga, Benoit R. Gauthier, Noureddine Khiar
Summary: We have reported the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, in the presence of the enzyme alkaline phosphatase (ALP) for the first time. This was achieved by prior functionalization of the MOF with N-3-PEG-PO3 ligands, which imparted colloidal stability in phosphate-containing media, endowed the MOF with multifunctionality, and conferred stimuli-responsive properties for the selective release of doxorubicin triggered by ALP activity. Cell studies demonstrated improved intracellular stability and sustained drug release in the functionalized MOF compared to the bare MOF, with enhanced drug release observed in cells with higher expression of ALP genes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina P. Kolesova, Vera S. Egorova, Anastasiia O. Syrocheva, Anastasiia S. Frolova, Dmitry Kostyushev, Anastasiia Kostyusheva, Sergey Brezgin, Daria B. Trushina, Landysh Fatkhutdinova, Mikhail Zyuzin, Polina A. Demina, Evgeny V. Khaydukov, Andrey A. Zamyatnin, Alessandro Parodi
Summary: Proteolytic activity plays a crucial role in cell homeostasis and function, with implications in cancer progression and treatment response. Endosomes, which are often the final destination of internalized nanoparticles, are major sites of cellular proteolytic activity. However, little is known about the impact of nanoparticles on endosomal biology. In this study, we generated albumin nanoparticles with varying resistance to proteolysis and demonstrated a relationship between their sensitivity to proteases and drug delivery properties, irrespective of the degree of proteolytic degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Fatima Guerrero, Andres Carmona, Victoria Vidal, Ana Franco, Alejandro Martin-Malo, Elena M. Sanchez-Fernandez, Carolina Carrillo-Carrion
Summary: An effective antioxidant nanoplatform, DSeU@ZIF8, was constructed by encapsulating a selenium-containing glycomimetic into zeolitic-imidazolate framework-8 nanoparticles. The nanoparticles showed remarkable antioxidant capacity and ROS-scavenging activity, and could protect endothelial cells from oxidative stress damage.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Fatima Guerrero, Victoria Pulido, Said Hamad, Pedro Aljama, Alejandro Martin-Malo, Carolina Carrillo-Carrion
Summary: This study demonstrates the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while still retaining their ability to remove hydrophobic uremic toxins like p-cresol under flow conditions. This could lead to the development of novel adsorbents for dialysis and/or artificial kidneys in the future.
Article
Chemistry, Physical
Ana Franco, Jose Angel Salatti-Dorado, Valentin Garcia-Caballero, Sebastian Lorca, Luis Camacho, Manuel Cano, Antonio J. Fernandez-Romero, Juan J. Delgado, Juan J. Giner-Casares, Carolina Carrillo-Carrion
Summary: A new ultrathin and water-stable 2D Cu-based metal-organic framework has been synthesized with notable electrocatalytic activity for the oxygen reduction reaction in alkaline media, showing excellent performance in both alkaline flooded and all-solid-state Zn-air batteries.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Review
Chemistry, Inorganic & Nuclear
Alberto Escudero, Carolina Carrillo-Carrion, Elena Romero-Ben, Ana Franco, Christian Rosales-Barrios, Ma Carmen Castillejos, Noureddine Khiar
Summary: Chemical routes for the synthesis of nanostructures are fundamental in nanoscience. This article focuses on wet chemistry synthesis, providing a general overview of the synthesis of different inorganic and hybrid organic-inorganic nanostructures. It is suitable for early researchers and non-specialist readers with a basic background in chemistry.
Article
Chemistry, Physical
M. Dolores Marquez-Medina, Rafael Luque, Alina M. Balu, Francisco Ivars-Barcelo, Carolina Carrillo-Carrion
Summary: Mesoporous silica materials were successfully doped with transition metals (Zr and Fe) through a mechano-chemical approach, yielding significantly improved catalytic performance even at low doping levels for selective mild oxidation reactions under microwave irradiation. Fe-doped materials showed the highest yields and can be reused multiple times, demonstrating the potential for sustainable applications. Incorporating metals into the structure enhanced total acidity of the support, leading to improved catalytic performance for oxidation reactions.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Alberto Escudero, Carolina Carrillo-Carrion, Ma Carmen Castillejos, Elena Romero-Ben, Christian Rosales-Barrios, Noureddine Khiar
Summary: This article discusses the application of photodynamic therapy in treating skin, eye diseases, and cancer, focusing on different photosensitizers, their chemical properties, their applications in nanostructures, and targeting strategies.
MATERIALS CHEMISTRY FRONTIERS
(2021)
