Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-infiltrating NY-ESO-1–specific CD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

(2010) Junko Matsuzaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

Modulation of T Lymphocyte Replicative Senescence via TNF-  Inhibition: Role of Caspase-3

(2009) S. T. Parish et al.   JOURNAL OF IMMUNOLOGY

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

(2008) M. Lichterfeld et al.   BLOOD

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Phenotype and function of human T lymphocyte subsets: Consensus and issues

(2008) Victor Appay et al.   CYTOMETRY PART A

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

(2008) D. G. Brooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing ageing of individual T lymphocytes: Mission impossible?

(2007) Emanuela M. Iancu et al.   MECHANISMS OF AGEING AND DEVELOPMENT