Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Deficiency of IL-17A, but not the prototypical Th17 transcription factor RORγt, decreases murine spontaneous intestinal tumorigenesis

(2015) Mia Shapiro et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

(2015) Xiao Hu et al.   Nature Chemical Biology

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS

(2015) Miguel F. Sanmamed et al.   SEMINARS IN ONCOLOGY

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+T cell responses

(2015) Robert J Johnston et al.   OncoImmunology

GM-CSF and ipilimumab therapy in metastatic melanoma: Clinical outcomes and immunologic responses

(2015) Serena S. Kwek et al.   OncoImmunology

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

(2014) S. Guedan et al.   BLOOD

Immune modulation for cancer therapy

(2014) J Naidoo et al.   BRITISH JOURNAL OF CANCER

Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors

(2014) S. Chatterjee et al.   CANCER RESEARCH

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

(2014) Christopher J Chan et al.   NATURE IMMUNOLOGY

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Chimeric Antigen Receptor Therapy for Cancer

(2013) David M. Barrett et al.   Annual Review of Medicine

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

(2013) G. L. Beatty et al.   Cancer Immunology Research

Increased Frequency of ICOS+ CD4 T Cells as a Pharmacodynamic Biomarker for Anti-CTLA-4 Therapy

(2013) D. Ng Tang et al.   Cancer Immunology Research

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

(2012) Fanny Chalmin et al.   IMMUNITY

The TIGIT/CD226 Axis Regulates Human T Cell Function

(2012) E. Lozano et al.   JOURNAL OF IMMUNOLOGY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

(2010) Kiyoshi Hirahara et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Adoptive Transfer of Tumor-Specific Tc17 Effector T Cells Controls the Growth of B16 Melanoma in Mice

(2010) M. d. l. L. Garcia-Hernandez et al.   JOURNAL OF IMMUNOLOGY

The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells

(2010) C. M. Paulos et al.   Science Translational Medicine

Type 17 CD8+ T cells display enhanced antitumor immunity

(2009) C. S. Hinrichs et al.   BLOOD

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

Differentiation and function of pro-inflammatory Th17 cells

(2009) Chen Dong   MICROBES AND INFECTION

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

(2009) N. Stanietsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE