期刊
FRONTIERS IN IMMUNOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2016.00574
关键词
Treg cell; exosome; non-coding RNA; resident Treg cell; Treg homeostasis
类别
资金
- National Key Technology Research and Development program of the Ministry of Science and Technology of China [2014BAI04B02]
- Graduate Research and Innovation Projects in Hunan Province [CX2015B056]
- Mittal Innovative Entrepreneurial Project of Central South University [15MX43]
Regulatory T (Treg) cells are a group of cells that are heterogeneous in origin and in functional activity. Treg cells comprise a necessary balance to adaptive immune responses. As key regulators of self-tolerance, Treg cells have been involved in a series of pathologic processes and considered as therapeutic targets. Here, we summarize recent research regarding Treg cell origins and their functional classification, highlight the role of exosomes and non-coding RNA in modulating Treg cell homeostasis, and discuss the current understanding of resident Treg cells.
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