Article
Urology & Nephrology
Nancy S. Krieger, John Asplin, Ignacio Granja, Luojing Chen, Daiana Spataru, Tong Tong Wu, Marc Grynpas, David A. Bushinsky
Summary: In this study, the effects of potassium citrate and chlorthalidone on calcium oxalate stone formation and bone quality were investigated using a genetic hypercalciuric stone-forming rat model. The results showed that potassium citrate plus chlorthalidone combination was more effective in reducing stone formation, while chlorthalidone alone improved bone quality.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Daniel Rodriguez, Ekaterina Gurevich, Soroush Mohammadi Jouabadi, Eva Maria Pastor Arroyo, Alexander Ritter, Sandrine Estoppey Younes, Carsten A. Wagner, Pedro Henrique Imenez Silva, Harald Seeger, Nilufar Mohebbi
Summary: This study investigated the association between serum sclerostin levels and recurrent kidney stone formation. The findings suggest that sclerostin levels are increased in recurrent kidney stone formers, particularly in women. There was an association between serum sclerostin and the status as a recurrent kidney stone former, independent of hypercalciuria. However, further studies are needed to understand the underlying mechanisms.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Chan Jung Liu, Yau Sheng Tsai, Ho Shiang Huang
Summary: This study demonstrates that statins can suppress hyperlipidemia-induced CaOx nephrolithiasis by restoring the expression of anti-lithic protein, leading to a decrease in renal CaOx stone deposits and a change in the dominant calcium crystal composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Roswitha Siener, Maria Sofie Pitzer, Jan Speller, Albrecht Hesse
Summary: This study examined the profile of patients with brushite nephrolithiasis and the impact of diet on stone formation. It found that dietary intervention can effectively reduce the relative supersaturation of brushite and should be integrated into the treatment of brushite stone disease.
Article
Biochemistry & Molecular Biology
Shang Guo, Weekai Chia, Hongwei Wang, David A. Bushinsky, Biao Zhong, Murray J. Favus
Summary: The study reveals that elevated VDR expression in a genetic hypercalciuric stone-forming rat model may contribute to the development of hypercalciuria by regulating the expression of target genes and histone modifications at their promoter regions.
Article
Biochemistry & Molecular Biology
Sunisa Yoodee, Paleerath Peerapen, Sirikanya Plumworasawat, Visith Thongboonkerd
Summary: This study found that heat-shock protein 90 (HSP90) and its four functional domains play important roles in the formation of kidney stones, promoting the crystallization, growth, aggregation, adhesion onto renal cells, and invasion through the extracellular matrix (ECM) of calcium oxalate monohydrate (COM) crystals.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Urology & Nephrology
Joshua M. Stern, Robert D. Burk, John Asplin, Nancy S. Krieger, Sylvia O. Suadicani, Yi Wang, Mykhaylo Usyk, Justin A. Lee, Luojing Chen, Jennifer Becker, Michaela Chan, David A. Bushinsky
Summary: Antibiotics can alter the gut microbiome of genetic hypercalciuric stone-forming rats, impacting urine ion excretion and stone formation. Bactrim group showed reduced urine calcium and oxalate, increased CaP supersaturation and calcification, while the Cipro group exhibited increased urine citrate. Antibiotic-induced changes in the gut microbiome are likely contributing factors to alterations in urine chemistry, supersaturation and stone risk.
Article
Nutrition & Dietetics
Roswitha Siener, Patricia Loehr, Albrecht Hesse
Summary: Dietary intervention is crucial in managing uric acid nephrolithiasis, as it can reduce the risk of stone formation by increasing urine pH and volume to decrease the supersaturation of uric acid.
Article
Pediatrics
Andrew M. Fang, Elena Gibson, Robert A. Oster, Pankaj P. Dangle
Summary: This study investigated urine chemistry factors in pediatric stone formers in the Southeast United States, finding that non-overweight patients were more likely to have hyperoxaluria and hyperuricosuria, while overweight patients were more likely to have hypocitraturia. Female patients were more likely to have higher hyperoxaluria, while male patients were more likely to have hypercalciuria.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Review
Pediatrics
Bulent Onal, Elif Altinay Kirli
Summary: Treatment of pediatric urolithiasis involves medical and surgical approaches with the goal of preventing stone recurrence. Recent advancements in medical diagnostic evaluation and surgical treatment include the discovery that single mutations may be responsible for a larger proportion of renal stones. The adoption of miniaturized instruments and minimally invasive endoscopic surgery has become the preferred treatment method.
TURKISH ARCHIVES OF PEDIATRICS
(2021)
Article
Urology & Nephrology
Zheng Liu, Yucong Zhang, Guoliang Sun, Wei Ouyang, Shen Wang, Hao Xu, Henglong Hu, Fan Li, Jun Yang, Zhihua Wang, Wei Guan, Xiao Yu, Zhiquan Hu, Zhong Chen, Shaogang Wang, Gongwei Long, Heng Li
Summary: Thulium laser resection of bladder tumors (TmLRBT) is a safer technique than conventional transurethral resection of bladder tumor (TURBT) in the treatment of non-muscle-invasive bladder cancer (NMIBC), with a higher detrusor identification rate and fewer postoperative complications.
UROLOGIA INTERNATIONALIS
(2022)
Article
Biochemistry & Molecular Biology
Yang Xun, Peng Zhou, Yuanyuan Yang, Cong Li, Jiaqiao Zhang, Henglong Hu, Baolong Qin, Zongbiao Zhang, Qing Wang, Yuchao Lu, Shaogang Wang
Summary: The study demonstrates the crucial role of Nox4 in kidney stone pathology, showing that calcium exacerbates renal oxidative stress injury and crystal deposition by activating the Nox4-related ROS-ERK/JNK pathway. This research provides a new theoretical basis for the prevention and treatment of kidney stones.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Urology & Nephrology
Xiaoyuan Qian, Weisong Wu, Henglong Hu, Xiao Yu, Shaogang Wang, Jianning Zhu, Jiaqiao Zhang
Summary: This study investigated the role of reactive oxygen species (ROS) from different sources in oxalate-induced renal tubular epithelial cell injury. The researchers identified potential targets for preventing or alleviating oxalate-induced cell injury.
Article
Genetics & Heredity
Sheng Xin, Jiaquan Mao, Chen Duan, Jiaxin Wang, Yuchao Lu, Jun Yang, Jia Hu, Xiaming Liu, Wei Guan, Tao Wang, Shaogang Wang, Jihong Liu, Wen Song, Xiaodong Song
Summary: In this study, the necroptosis landscape of KIRC patients was quantified and two distinct necroptosis-related patterns were identified. A stable and accurate prognostic marker called NRGscore was constructed, which showed significant correlations with clinicopathological characteristics, tumor immune microenvironment, and tumor mutation burden of KIRC patients. NRGscore also had effective guiding significance for immunotherapy, chemotherapy, and targeted drugs.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Jin-Zhou Xu, Jun-Lin Lu, Liu Hu, Yang Xun, Zheng-Ce Wan, Qi-Dong Xia, Xiao-Yuan Qian, Yuan-Yuan Yang, Sen-Yuan Hong, Yong-Man Lv, Shao-Gang Wang, Xiao-Mei Lei, Wei Guan, Cong Li
Summary: Among Chinese adults, there is a dose-response association between UA level and KS in men but not in women. However, the association becomes considerably weak in male participants with malnutrition status.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, Research & Experimental
Xian-Miao Li, Huan-Lei Wu, Qi-Dong Xia, Peng Zhou, Shao-Gang Wang, Xiao Yu, Jia Hu
Summary: Ubiquitin-mediated protein degradation is a crucial process for maintaining protein homeostasis in eukaryotic cells. SPOP, as a substrate adaptor of the CRL3 family, has garnered attention for its versatility in regulatory pathways and involvement in various tumor types. Abnormalities in SPOP can disrupt downstream biological processes and promote tumorigenesis, while liquid-liquid phase separation may play a role in the interaction between SPOP and its substrates.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Xiaoyuan Qian, Junlai Wan, Jinzhou Xu, Chenqian Liu, Mingliang Zhong, Jiaqiao Zhang, Ying Zhang, Shaogang Wang
Summary: Between 1990 and 2019, the global incidence of urolithiasis increased while the age-standardized incidence rate decreased, with mortality and DALYs increasing. The burden of urolithiasis was greater in males compared to females, showing significant differences in geographic, age, and sex distribution over the past three decades.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Yuanyuan Yang, Qing Wang, Yang Xun, Cong Li, Shaogang Wang
Summary: By analyzing microRNAs derived from urinary small extracellular vesicles (sEVs), we identified significantly higher expression of miR-223-3p in patients with nephrolithiasis, which may affect stone formation through regulating oxidative stress, focal adhesion, and inflammation processes.
Review
Microbiology
Sen-Yuan Hong, Qi-Dong Xia, Yuan-Yuan Yang, Cong Li, Jia-Qiao Zhang, Jin-Zhou Xu, Bao-Long Qin, Yang Xun, Shao-Gang Wang
Summary: Urolithiasis is a common disease with increasing prevalence and recurrence rate worldwide. Recent advancements in sequencing technologies and culturomics have revealed the important role of the human microbiome, both in the urinary tract and intestines, in the etiology and pathogenesis of urolithiasis.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Andrology
Taotao Sun, Wenchao Xu, Jiaxin Wang, Tao Wang, Shaogang Wang, Kang Liu, Jihong Liu
Summary: This study investigated the effect and possible mechanisms of Saxagliptin (Sax) in the treatment of diabetes mellitus-induced erectile dysfunction (DMED). The results showed that Sax could alleviate DMED by increasing SDF-1 and activating the PI3K/AKT pathway, while also mitigating endothelial dysfunction, oxidative stress, and apoptosis. This suggests that DPP-4 may be beneficial for the management of DMED.
Review
Medicine, General & Internal
Henglong Hu, Mengqi Zhou, Binrui Yang, Shiwei Zhou, Zheng Liu, Jiaqiao Zhang
Summary: International guidelines recommend repeat transurethral resection of bladder tumors (reTURB) for selected patients with high-risk non-muscle invasive bladder cancer to remove possible residual tumors, restage tumors and improve the therapeutic outcome. However, this study shows that reTURB after initial En bloc resection of bladder tumor (ERBT) does not improve recurrence or progression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Andrology
Zhe Tang, Jingyu Song, Zhe Yu, Kai Cui, Yajun Ruan, Yang Liu, Tao Wang, Shaogang Wang, Jihong Liu, Jun Yang
Summary: This study demonstrates that miRNA-92a inhibitor can effectively inhibit oxidative stress and endothelial dysfunction in diabetic erectile dysfunction (ED), thus improving erectile function in diabetic rats.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoyan Meng, Shichao Li, Kangwen He, Henglong Hu, Cui Feng, Zhen Li, Yanchun Wang
Summary: This study evaluated the feasibility of texture analysis based on diffusion kurtosis imaging (DKI) for staging and grading bladder cancer (BC), and compared it with apparent diffusion coefficient (ADC) and biparametric vesical imaging reporting and data system (VI-RADS). The results showed that DKI-based texture analysis is useful in evaluating the staging and grading of BC, and the histogram parameters of DKI can provide additional value to VI-RADS.
BIOENGINEERING-BASEL
(2023)
Article
Andrology
Kang Liu, Taotao Sun, Wenchao Xu, Jingyu Song, Yinwei Chen, Yajun Ruan, Hao Li, Kai Cui, Yan Zhang, Yuhong Feng, Jiancheng Pan, Enli Liang, Zhongcheng Xin, Tao Wang, Shaogang Wang, Jihong Liu, Yang Luan
Summary: RLX-2 improves erectile dysfunction in rats with bilateral cavernous nerve injury by protecting cavernous nerves and endothelial function, and suppressing fibrosis and apoptosis.
WORLD JOURNAL OF MENS HEALTH
(2023)
