期刊
FRONTIERS IN PHYSIOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2016.00075
关键词
essential genes/proteins; machine learning; systems biology; prediction models; network topological features
类别
资金
- National Natural Science Foundation of China [61402423, 61502343, 61303112]
- Guizhou Provincial Science and Technology Fund [[2015]2135]
- Sao Paulo Research Foundation (FAPESP, Brazil) [2013/02018-4]
- Coordination for the Improvement of Higher Education Personnel (CAPES) in Brazil
Essential proteins/genes are indispensable to the survival or reproduction of an organism, and the deletion of such essential proteins will result in lethality or infertility. The identification of essential genes is very important not only for understanding the minimal requirements for survival of an organism, but also for finding human disease genes and new drug targets. Experimental methods for identifying essential genes are costly, time-consuming, and laborious. With the accumulation of sequenced genomes data and high-throughput experimental data, many computational methods for identifying essential proteins are proposed, which are useful complements to experimental methods. In this review, we show the state-of-the-art methods for identifying essential genes and proteins based on machine learning and network topological features, point out the progress and limitations of current methods, and discuss the challenges and directions for further research.
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