Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling

Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner

(2016) Jyoti Joshi Mundra et al.   Scientific Reports

Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss

(2015) A.I. Espirito Santo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice

(2015) Takaaki Noguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass

(2015) L Wang et al.   CELL DEATH AND DIFFERENTIATION

Serum and synovial fluid levels of tumor necrosis factor-like ligand 1A and decoy receptor 3 in rheumatoid arthritis

(2015) Zijuan Xiu et al.   CYTOKINE

The molecular basis for development of proinflammatory autoantibodies to progranulin

(2015) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator

(2015) Arianne C. Richard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?

(2015) Jian-lu Wei et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture

(2015) Steven A. Olson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases

(2015) Spyros I. Siakavellas et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

(2015) Yun-peng Zhao et al.   Scientific Reports

3D-Printed Atsttrin-Incorporated Alginate/Hydroxyapatite Scaffold Promotes Bone Defect Regeneration with TNF/TNFR Signaling Involvement

(2015) Quan Wang et al.   Advanced Healthcare Materials

Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice

(2015) Fraser L. Collins et al.   Journal of Immunology Research

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis

(2014) Min Zhou et al.   CYTOKINE

Proinflammatory Progranulin Antibodies in Inflammatory Bowel Diseases

(2014) Lorenz Thurner et al.   DIGESTIVE DISEASES AND SCIENCES

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity

(2014) Qingyun Tian   Frontiers in Bioscience-Landmark

Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis

(2014) Yasuko Yamamoto et al.   INFLAMMATION

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

TL1A Induces TCR Independent IL-6 and TNF-α Production and Growth of PLZF+ Leukocytes

(2014) Kirsten Reichwald et al.   PLoS One

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

(2014) Cui Liu et al.   PLoS One

Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions

(2014) Fanhua Wei et al.   PLoS One

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner

(2014) Fanhua Wei et al.   Scientific Reports

Editorial: Balancing Tumor Necrosis Factor Receptor I and Tumor Necrosis Factor Receptor II Jointly for Joint Inflammation

(2014) Bharat B. Aggarwal   Arthritis & Rheumatology

Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen-Induced Arthritis

(2014) Fiona E. McCann et al.   Arthritis & Rheumatology

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

(2013) Yun-peng Zhao et al.   BIOMATERIALS

Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone ResorptionIn VitroandIn Vivo

(2013) Hideki Kitaura et al.   Clinical & Developmental Immunology

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

(2013) Jinlong Jian et al.   FEBS LETTERS

Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine

(2013) Wen-Fang Xia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis

(2013) Lorenz Thurner et al.   ARTHRITIS RESEARCH & THERAPY

Efficacy of Infliximab in a Rabbit Model of Osteoarthritis

(2012) Qiankun Zhang et al.   CONNECTIVE TISSUE RESEARCH

On death receptor 3 and its ligands…

(2012) Eddie C. Y. Wang   IMMUNOLOGY

Progranulin antibodies in autoimmune diseases

(2012) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

Increased levels of soluble TNF-like cytokine 1A in ankylosing spondylitis

(2012) M. Konsta et al.   RHEUMATOLOGY

Tregs Expanded In Vivo by TNFRSF25 Agonists Promote Cardiac Allograft Survival

(2012) Dietlinde Wolf et al.   TRANSPLANTATION

Mechanisms and clinical relevance of TRAIL-triggered responses in the synovial fibroblasts of patients with rheumatoid arthritis

(2011) Rachel Audo et al.   ARTHRITIS AND RHEUMATISM

Progranulin: A promising therapeutic target for rheumatoid arthritis

(2011) Chuan-ju Liu   FEBS LETTERS

Progranulin: A growth factor, a novel TNFR ligand and a drug target

(2011) Chuan-ju Liu et al.   PHARMACOLOGY & THERAPEUTICS

Progranulin Resolves Inflammation

(2011) H. Wu et al.   SCIENCE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

(2010) Gareth W. Jones et al.   FASEB JOURNAL

The TNF-Like Protein 1A-Death Receptor 3 Pathway Promotes Macrophage Foam Cell Formation In Vitro

(2010) J. E. McLaren et al.   JOURNAL OF IMMUNOLOGY

Age-Dependent Maintenance of Motor Controland Corticostriatal Innervation by Death Receptor 3

(2010) J. P. Twohig et al.   JOURNAL OF NEUROSCIENCE

Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis

(2009) P. L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Role of TL1A in the Pathogenesis of Rheumatoid Arthritis

(2009) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Nerve Growth Factor in Rheumatic Diseases

(2009) Matthias F. Seidel et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Comprehensive Linkage and Association Analyses Identify Haplotype, Near to the TNFSF15 Gene, Significantly Associated with Spondyloarthritis

(2009) Elena Zinovieva et al.   PLoS Genetics

Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis

(2008) Giorgos Bamias et al.   CLINICAL IMMUNOLOGY

The TNF-Family Receptor DR3 is Essential for Diverse T Cell-Mediated Inflammatory Diseases

(2008) Françoise Meylan et al.   IMMUNITY

The Death Receptor 3–TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis

(2008) Melanie Jane Bull et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A Both Promotes and Protects from Renal Inflammation and Injury

(2008) R. S. Al-Lamki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY