Progranulin: A promising therapeutic target for rheumatoid arthritis

HDL/Apolipoprotein A-I Binds to Macrophage-Derived Progranulin and Suppresses its Conversion into Proinflammatory Granulins

(2011) Hanayuki Okura et al.   Journal of Atherosclerosis and Thrombosis

Progranulin Resolves Inflammation

(2011) H. Wu et al.   SCIENCE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis

(2010) Stephan Blüml et al.   ARTHRITIS AND RHEUMATISM

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

TNF Activates a NF- B-Regulated Cellular Program in Human CD45RA- Regulatory T Cells that Modulates Their Suppressive Function

(2010) M. Nagar et al.   JOURNAL OF IMMUNOLOGY

Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response

(2010) Kai Kessenbrock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth

(2010) Li Kong et al.   MATRIX BIOLOGY

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

(2010) Vivianna M Van Deerlin et al.   NATURE GENETICS

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Sorting Out Frontotemporal Dementia?

(2010) Jada Lewis et al.   NEURON

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity

(2009) X. H. Bai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor

(2009) X.-H. Bai et al.   MOLECULAR AND CELLULAR BIOLOGY

The risk of herpes zoster: another cost of anti-TNF therapy?

(2009) Tim Bongartz et al.   Nature Reviews Rheumatology

Malignancy and biologic therapy in rheumatoid arthritis

(2008) Johan Askling et al.   CURRENT OPINION IN RHEUMATOLOGY

Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma

(2008) Jenny C. Ho et al.   HEPATOLOGY

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding

(2008) G. S. Butler et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

(2008) Dmitri Tolkatchev et al.   PROTEIN SCIENCE

Therapeutic advances in rheumatology with the use of recombinant proteins

(2008) Achim Rothe et al.   Nature clinical practice. Rheumatology

The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis

(2008) Chuan-Ju Liu   Nature clinical practice. Rheumatology

Serum level of cartilage oligomeric matrix protein (COMP) in equine osteoarthritis

(2007) K. MISUMI et al.   EQUINE VETERINARY JOURNAL