Article
Endocrinology & Metabolism
Katherine Veras, Camila Ferraz Lucena, Julia Goedcke, Fabiana S. Evangelista, Angelo Carpinelli, Carla Roberta de Oliveira Carvalho
Summary: This study evaluated the effects of moderated aerobic treadmill exercise training on pancreatic islet cell viability and function in mice consuming a high-fat and sucrose diet. The results showed that exercise training can slow down and prevent adverse metabolic effects associated with consuming a westernized diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Maria Eugenia Oliva, Maria del Rosario Ferreira, Michelle Berenice Vega Joubert, Maria Eugenia D'Alessandro
Summary: This study found that supplementation with chia seed can reduce abdominal and thoracic circumferences, carcass fat content, adipose tissue weights, and visceral adiposity index in rats fed with a sucrose-rich diet. Furthermore, it improved insulin sensitivity and plasma lipid profile. The reduction in fat cell triglyceride content and activities of fat synthesis enzymes in epididymal adipose tissue were associated with the modulation of essential pathways of lipid metabolism by chia seed supplementation.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Lichun Chen, Songwen Xue, Binhao Dai, Huimin Zhao
Summary: This study evaluated the effects of various dietary oils on obese mice and found that coix seed oil (CSO) has anti-obesity properties and can improve lipid metabolism. CSO contains a high content of medium-chain fatty acids, which can modify hepatic fatty acid metabolism and lipid levels.
Article
Endocrinology & Metabolism
Vedrana Ivic, Milorad Zjalic, Senka Blazetic, Matija Fenrich, Irena Labak, Rudolf Scitovski, Kalman Ferenc Szucs, Eszter Ducza, Tamas Tabi, Fruzsina Bagamery, Eva Szoko, Rosemary Vukovic, Alen Roncevic, Dario Mandic, Zeljko Debeljak, Monika Berecki, Marta Balog, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Judit Hajagos-Toth, Srecko Gajovic, Alen Imsirovic, Marina Bakula, Solomiia Mahiiovych, Robert Gaspar, Sandor G. Vari, Marija Heffer
Summary: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet. Unexpectedly, both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Xiaohua Huang, Yong Zhuo, Dandan Jiang, Yingguo Zhu, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Lun Hua, Yuanfeng Zou, Chao Huang, Lixia Li, De Wu, Bin Feng
Summary: Maternal low-protein diet during puberty and adulthood may disrupt metabolic gene expression in the liver of offspring and exacerbate insulin resistance and hepatic steatosis in offspring fed a high-fat diet.
Article
Cardiac & Cardiovascular Systems
Yanan Liu, Mengke Li, Xue Lv, Kaiwen Bao, Xiao Yu Tian, Lei He, Lei Shi, Yi Zhu, Ding Ai
Summary: The study reveals that YAP protein is upregulated in metabolic syndrome and leads to the activation of the TGF beta pathway, resulting in arterial stiffness. It is found that YAP inhibits the dephosphorylation of Smads through removal of the ubiquitin chain. These findings are significant for the development of therapeutic targets for metabolic syndrome-associated arterial stiffness.
CIRCULATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ryan A. Frieler, Thomas M. Vigil, Jianrui Song, Christy Leung, Carey N. Lumeng, Richard M. Mortensen
Summary: This study showed that a high-fat/high-salt diet can reduce weight gain but does not prevent the metabolic consequences of a high-fat diet, leading to elevated blood glucose levels and impaired glucose control.
Article
Pharmacology & Pharmacy
Hiba Natsheh, Elka Touitou
Summary: In this study, a phospholipid oily gel for nasal administration was designed and tested for its effectiveness in improving memory. The results showed significantly improved behavior in animals treated nasally, and enhanced delivery of fluorescent probes to the brain through nasal administration.
Article
Endocrinology & Metabolism
Dongming Wu, Zhenyuan Zhang, Wenxiu Sun, Yong Yan, Mengzhe Jing, Shizhan Ma
Summary: This study confirmed the effect of G0S2 on insulin resistance and revealed that G0S2 overexpression in mice fed a high-fat diet resulted in enhanced insulin resistance. Proteomic analysis identified differentially expressed proteins associated with insulin signaling pathway and demonstrated the potential of G0S2 as a target gene for the treatment of metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S. Alexander, Hitoshi Shimano, Hirohito Sone
Summary: SOCS3 protein plays a critical role in regulating obesity and diabetes, but the mechanism of action and the relationship with gut microbiota remain to be clarified.
Article
Food Science & Technology
Jieping Yang, Patrizia Maria Germano, Suwan Oh, Sijia Wang, Jing Wang, Rupo Lee, Hayden Paige, Scarlet Yang, Susanne M. Henning, Jin Zhong, Jonathan P. Jacobs, Zhaoping Li
Summary: This study found that dietary supplementation of pomegranate extract (PomX) can ameliorate colitis and reduce inflammatory markers in mice fed a Western diet. These effects may be mediated by the impact of PomX on the gut microbiome.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kirsi-Marja Zitting, Ramalingam Vetrivelan, Robin K. Yuan, Nina Vujovic, Wei Wang, Sathyajit S. Bandaru, Stuart F. Quan, Elizabeth B. Klerman, Frank A. J. L. Scheer, Orfeu M. Buxton, Jonathan S. Williams, Jeanne F. Duffy, Clifford B. Saper, Charles A. Czeisler
Summary: This study examines the effects of circadian disruption on metabolism in both mice and humans. The results show that circadian disruption, even in the absence of significant sleep loss, has a negative impact on glucose metabolism in individuals consuming a high-fat diet. Reducing dietary fat intake may help protect against the metabolic consequences of chronic circadian disruption.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Medicine, Research & Experimental
Francisco Moreno, Lucia Mendez, Ana Raner, Bernat Miralles-Perez, Marta Romeu, Sara Ramos-Romero, Josep Lluis Torres, Isabel Medina
Summary: A high intake of saturated fats and refined carbohydrates is associated with cognitive impairment and the aggravation of neurodegenerative diseases. This study found that this diet can lead to oxidative damage to brain proteins, but fish oil supplementation can counteract this damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Amanda E. Brandon, Lewin Small, Tuong-Vi Nguyen, Eurwin Suryana, Henry Gong, Christian Yassmin, Sarah E. Hancock, Tamara Pulpitel, Sophie Stonehouse, Letisha Prescott, Melkam A. Kebede, Belinda Yau, Lake-Ee Quek, Greg M. Kowalski, Clinton R. Bruce, Nigel Turner, Gregory J. Cooney
Summary: Obesity is generally associated with insulin resistance and increased risk of developing type 2 diabetes, but there is a subset of obese individuals who remain insulin sensitive. Recent research suggests that high carbohydrate diets can cause obesity in mice without glucose intolerance. This study found that dietary manipulation can influence insulin action independently of adiposity, and specific ceramide species may be associated with these differences.