Article
Biotechnology & Applied Microbiology
Yuming Yang, Yu Han, Qiuyang Sun, Jin Cheng, Caixia Yue, Yanlei Liu, Jie Song, Weilin Jin, Xianting Ding, Jesus M. de la Fuente, Jian Ni, Xiaoqiang Wang, Daxiang Cui
Summary: This paper presents a highly efficient combination nanocarrier for gene and chemical therapy, achieving targeted gene silencing and tumor inhibition. In mouse experiments, this treatment showed high tumor inhibition ratio and increased survival rate, demonstrating great potential for clinical application.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nandan Gupta, Rishabha Malviya
Summary: The use of gold nanoparticles in photothermal therapy for cancer treatment is highlighted in this communication, showing their potential in warning cancer cells to other therapies, modulating cellular permeability and delivery, and achieving effective therapy management.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Pharmacology & Pharmacy
Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: Despite the clinical benefits of chemotherapeutics, drug resistance remains a major challenge in breast cancer treatment. Nanomedicines, such as porous silicon nanoparticles (pSiNPs), offer a targeted and effective approach by delivering multiple therapeutics and minimizing drug resistance. In this study, breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs) were engineered. The combination of hyperthermia and chemotherapy using targeted pSiNPs showed higher cell-killing efficacy compared to monotherapy and a nontargeted system with combined therapeutics. These findings highlight the potential of targeted pSiNPs as a versatile platform for personalized medicine.
Article
Chemistry, Multidisciplinary
Satish S. Phalake, Sandeep B. Somvanshi, Syed A. M. Tofail, Nanasaheb D. Thorat, Vishwajeet M. Khot
Summary: This study investigated the effectiveness of MIONP-based magneto-chemotherapy (MCT) in a 3D breast cancer model, using advanced 3D in vitro tumor models as a promising alternative to replicate the complete range of tumor characteristics. The results demonstrated that MCT using MIONPs reduced the viability of breast cancer cells, with the most promising therapeutic effects observed in the 3D cancer model.
Article
Chemistry, Multidisciplinary
Satish S. Phalake, Sandeep B. Somvanshi, Syed A. M. Tofail, Nanasaheb D. Thorat, Vishwajeet M. Khot
Summary: Localized heat generation from manganese iron oxide nanoparticles conjugated with chemotherapeutics under the exposure of an alternating magnetic field can revolutionize targeted breast cancer therapy. Advanced 3D in vitro tumor models are explored as a promising alternative to replicate the complete range of tumor characteristics. The effectiveness of magneto-chemotherapy using chitosan-coated MIONPs is investigated in a 3D breast cancer model, with successful reduction in cancer cell viability.
Article
Engineering, Environmental
Yanan Hu, Shuocheng Huang, Xingjun Zhao, Linna Chang, Xiuli Ren, Xifan Mei, Zhenhua Chen
Summary: The study developed a nanoplatform AuNCs-Plu-IR780 that is photothermal responsive and can generate ROS for cancer therapy, demonstrating potential therapeutic advantages in the field of cancer photothermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Subin Son, Jungryun Kim, Jaewon Kim, Byungkook Kim, Jieun Lee, Yuri Kim, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Light-based phototherapy has limitations in cancer treatment due to its limited penetration depth. To overcome these limitations, various energy sources such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field have been developed. Combining these energy sources with other strategies or therapies can improve the effectiveness of cancer treatment.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Dnyaneshwar Kalyane, Suryanarayana Polaka, Nupur Vasdev, Rakesh Kumar Tekade
Summary: This study presents a quality-by-design approach to develop targeted photothermal nanoseeds for the treatment of TNBC. These nanoseeds have nanometric size, show reversible photothermal effect upon laser activation, and exhibit significant anticancer activity.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yan Sun, Songcai Liu, Yuan Gao, Yangyang Du, Hongqiao Cai, Jian Zhang, Zhaoguo Wang, Xi Yang, Linlin Hao, Fei Yan
Summary: The study demonstrates a novel approach of combining photothermal therapy (PTT) with DNMT1 inhibitor-mediated chemotherapy for hepatocellular carcinoma (HCC) treatment. Decitabine-loaded gold nanocages with PEGylated-T7 peptide surface modification were successfully synthesized, showing selective accumulation at tumor sites and tumor cell ablation upon NIR irradiation. Activation of tumor suppressor genes silenced by PTT-induced hyperthermia and DNA hypermethylation further supports the targeted and effective synergistic PTT and chemotherapy against tumor growth.
ACS APPLIED NANO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Song Shen, Jichuan Qiu, Da Huo, Younan Xia
Summary: Photothermal therapy shows great potential in killing cancer cells through hyperthermia. The efficacy is affected by various parameters, including the laser, photothermal transducers, spatial distribution of the transducers, bioeffect of the tissue (heat-sink effect, thermal conductivity), and real-time temperature monitoring.
Article
Chemistry, Multidisciplinary
Yuanwei Pan, Xuehua Ma, Chuang Liu, Jie Xing, Suqiong Zhou, Badri Parshad, Tanja Schwerdtle, Wenzhong Li, Aiguo Wu, Rainer Haag
Summary: A targeted and RA-loaded nanoplatform was developed to effectively suppress the growth of breast cancer stem cells and tumor formation through multivalent targeted capability and synergistic effect of photothermal therapy.
Article
Nanoscience & Nanotechnology
Lirong Zhang, Mengyu Yang, Qianzhe Li, Zijian Zhuang, Xin Sun, Beibei Yu, Xiaonan Qiu, Qinxin Wang, Miaomiao Zhang, Fengyi Du
Summary: In this study, triphenylphosphonium conjugated gold-doped porous carbon dots loaded with 5-aminolevulinic acid (ALA) were developed for mitochondrial-targeting combined therapy of breast cancer. The nanoparticles showed enhanced photothermal effect and delivered ALA to mitochondria via coordination interaction. The nanoparticles selectively accumulated in mitochondria, depleted glutathione, and caused reactive oxygen species damage. Additionally, hyperthermia induced by the nanoparticles disrupted mitochondrial homeostasis, leading to necrosis and apoptosis of tumor cells. The study demonstrated the potential of these nanoparticles as an innovative mitochondrial homeostasis destroyer for synergistic phototherapy of breast cancer.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Xuan Zhang, Qian Chen, Liyuan Zhang, Haiping Zheng, Chunjie Lin, Qunfang Yang, Tao Liu, Haigang Zhang, Xiaohong Chen, Lei Ren, Wenjun Shan
Summary: The study developed a tubule-specific nanocage for targeted delivery of Celastrol to tubular epithelial cells, showing promising results in treating renal fibrosis with increased therapeutic efficacy and reduced systemic toxicity compared to free Celastrol. Additionally, RNA sequencing data suggested that the nanocage's anti-fibrotic effect could be attributed to suppression of premature senescence in tubular epithelial cells via specific pathways.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia-Jie Xu, Wan-Chen Zhang, Ya-Wen Guo, Xiao-Yi Chen, You-Ni Zhang
Summary: This article discusses the therapeutic potential of metal nanoparticles as anticancer drugs, including their application in tumor targeting and the risk factors involved in clinical use.
Article
Oncology
Asrin Pakravan, Mehdi Azizi, Fariborz Rahimi, Farhad Bani, Farideh Mahmoudzadeh, Roya Salehi, Mehrdad Mahkam
Summary: A novel GNSs@Dox-Pol nanostructure was prepared for combined chemo-photothermal therapy of breast cancer cells, demonstrating high cell mortality and apoptotic effects.
CANCER NANOTECHNOLOGY
(2021)
