期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 36, 页码 6043-6051出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb01469k
关键词
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资金
- National Natural Science Foundation of China [81173023]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Graduate Student Innovation Project - Huahai Pharmaceutical Co
Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and further functionalized with the targeting ligand P-gp monoclonal antibody (PA) in an attempt to overcome MDR. The obtained drug delivery system (ETO@oxCNHs/PEG-PA) showed high drug loading efficiency, enhanced drug release under laser irradiation, improved cellular uptake and increased therapeutic effect both in vitro and in vivo. In addition, NIR laser irradiation had a synergistic effect on overcoming MDR. The MDR-overcoming mechanism could be the efficient cellular uptake, enhanced drug release and reduced drug efflux by P-gp. These results demonstrated that ETO@oxCNHs/PEG-PA could be a promising drug delivery system for cancer MDR reversion.
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