Article
Materials Science, Biomaterials
Yingxiao Sun, Xingdan Liu, Ji Tan, Dan Lv, Wengang Song, Rui Su, Ling Li, Xuanyong Liu, Liping Ouyang, Yun Liao
Summary: The study investigated the loading of strontium ranelate onto sulfonated three-dimensional PEEK porous structures, showing enhanced cell adhesion and improved bioactivity of MC3T3-E1 cells.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biophysics
An-tian Xu, Yi-wen Xie, Jian-gang Xu, Jia Li, Hui Wang, Fu-ming He
Summary: The study suggests that Sr-SLA has immunomodulatory ability in adjusting the functional status of macrophages, by inhibiting M1 polarization while promoting M2 polarization.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Lei Wang, Huazheng He, Xing Yang, Yinchang Zhang, Shouliang Xiong, Chao Wang, Xin Yang, Bo Chen, Qiang Wang
Summary: The study developed PEEK implants with antibacterial and osteogenic capabilities using bimetallic ions immersion method. The modified PEEK demonstrated enhanced antibacterial properties and promoted osteogenic differentiation in vitro and in vivo. Rat models showed limited bacterial infections and enhanced new bone formation with PEEK-PDA-Mn/Cu treatment compared to other PEEK implants.
MATERIALS TODAY ADVANCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chuan Zhou, Ziyu Ge, Lu Song, Jiahui Yan, Xinrui Lang, Yanzhen Zhang, Fuming He
Summary: Through whole-transcriptome RNA sequencing and experiments, CDH2 was identified as a key mediator of Sr-SLA-mediated bone regeneration. Knocking down CDH2 resulted in decreased MSC vitality and osteogenic differentiation, as well as diminished biocompatibility and osteoinductive effect of Sr-SLA. Additionally, Sr-SLA promoted the nuclear translocation of beta-catenin. Systemic administration of AAV9-CDH2i effectively inhibited bone formation induced by Sr-SLA. Therefore, biomaterial modifications targeting CDH2 may improve early osseointegration and bone healing.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Engineering, Biomedical
Kun Xu, Ke Li, Ye He, Xuan Li, Chuanchuan Lin, Jing Wu, Shaopeng Liu, Yao Ding, Yulu Yang, Shuangquan Gou, Peng Liu, Kaiyong Cai
Summary: In this study, Fe(III)TA nanoparticles (NPs) and acetyl Bletilla striata polysaccharide (acBSP) were introduced onto a titanium (Ti) substrate to create a Ti-TF-acBSP system. The Fe(III)TA NPs induced a hyperthermal effect under near-infrared (NIR) irradiation, leading to direct bacterial killing. Meanwhile, acBSP induced macrophage polarization into the pro-inflammatory M1 phenotype, enhancing phagocytosis ability and activating the host innate immunity. Furthermore, acBSP instructed macrophages to secrete pro-osteogenic cytokines, promoting osteogenic differentiation of MSCs. Animal experiments confirmed that the Ti-TF-acBSP implant effectively eliminated bacterial infection, enhanced pro-inflammatory cytokine expression, and induced bone-forming related factors. This functionalized Ti implant combines bactericidal, immunoregulatory, and osteogenic effects, and has potential for development of antibacterial orthopedic devices.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Medicinal
Stefania Lama, Amalia Luce, Giuseppe Bitti, Pilar Chacon-Millan, Annalisa Itro, Pasquale Ferranti, Giovanni D'Auria, Marcella Cammarota, Giovanni Francesco Nicoletti, Giuseppe Andrea Ferraro, Chiara Schiraldi, Michele Caraglia, Evzen Amler, Paola Stiuso
Summary: This study investigated the potential application of polycaprolactone/polydatin (PCL/PD) nanofiber scaffold in bone tissue engineering. The results showed that osteosarcoma cells and mesenchymal stem cells cultured on PD-PCL nanofiber scaffold exhibited enhanced cell adhesion and osteogenic differentiation.
Article
Dentistry, Oral Surgery & Medicine
Yangbo Xu, Liefen Zhang, Jiangang Xu, Jia Li, Hui Wang, Fuming He
Summary: The study showed that strontium-incorporated titanium implant surfaces by hydrothermal treatment enhanced osseointegration in diabetic rats, and also inhibited inflammation while promoting bone formation.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Biophysics
Bingbing Wang, Jingpin Lan, Haixia Qiao, Lei Xie, Hao Yang, He Lin, Xiaoming Li, Yong Huang
Summary: In this study, a bifunctional fusion peptide was designed and assembled onto a 3D scaffold, resulting in a scaffold with both antibacterial and osteogenic functions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Coatings & Films
Kang-qing Zuo, Zhi-yuan Gong, Gui-yong Xiao, Sheng-yun Huang, Chun-miao Du, Bing Liu, Dong-sheng Zhang, Yu-peng Lu
Summary: The microstructure of the phosphate coating on implant surface can be regulated by adjusting the Zn2+ concentration in the phosphate solution, leading to the evolution of crystal morphology from irregular granules to regular cubic blocks. The increase in Zn2+ concentration also results in an improvement in coating thickness, wettability and corrosion resistance.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kai Li, Xiang Lu, Shiwei Liu, Xiaodong Wu, Youtao Xie, Xuebin Zheng
Summary: The study demonstrated that boron-incorporated CS coatings promoted osteoblastic differentiation and angiogenesis while suppressing inflammatory response. Specifically, the F-BCS coating showed enhanced osseointegration compared to L-BCS and C-CS coatings in in vivo experiments.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ardeshir Lafzi, Azadeh Esmaeil Nejad, Maryam Rezai Rad, Mahshid Namdari, Tohid Sabetmoghaddam
Summary: This study aimed to quantify the release of silver ions and expression of osteogenic genes by MC3T3-E1 cells cultured on nano-HA and silver/strontium-coated titanium plates. The results showed that the addition of silver/strontium to nano-HA coatings increased the release of silver ions and enhanced the expression of osteogenic genes, particularly after 7 days.
Article
Electrochemistry
Kota Nozawa, Xuyang Zhang, Takuo Nakamura, Yuji Nashimoto, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku
Summary: Human mesenchymal stem cells (hMSCs) are valuable cell sources for regenerative medicine. This study focused on quantifying the changes in hMSC topography during osteogenic differentiation, using scanning ion conductance microscopy (SICM). The results showed that hMSCs underwent morphological changes during differentiation, with rapidly expanding clone (REC) exhibiting greater differentiation capacity compared to conventional hMSCs (cMSCs). The three-dimensional topographical information obtained from this study contributes to a deeper understanding of hMSC osteogenic differentiation and may have implications for future clinical applications.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Biomedical
Tingting Wu, Wenping Liu, Shusen Huang, Jiwen Chen, Fupo He, Huajun Wang, Xiaofei Zheng, Zhenyan Li, Huantian Zhang, Zhengang Zha, Zefeng Lin, Yuanfeng Chen
Summary: A novel scaffold material combining ginsenoside Rg1 and a strontium-containing mineral was developed to promote osteoporotic bone repair, enhancing mechanical strength, stimulating osteogenic differentiation, and suppressing osteoclastogenesis.
MATERIALS TODAY BIO
(2021)
Article
Biotechnology & Applied Microbiology
Yi-Jie Kuo, Chia-Hsien Chen, Pranjyan Dash, Yu-Chien Lin, Chih-Wei Hsu, Shao-Ju Shih, Ren-Jei Chung
Summary: The main causes of failure in implant surgery are prolonged exposure and tissue ischemia, along with bacterial infection caused by the medical environment and equipment. Developing an implant coating to guide tissue growth and promote antibacterial activity can greatly reduce the medical risk.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Jafar Azamat, Jaber Jahanbin Sardroodi, Leila Poursoltani, Darian Jahanshahi
Summary: The study investigated the removal of cadmium and lead ions from water using boron nitride nanosheet membrane with functionalized pores and applied voltage, showing good performance in heavy metals separation process.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Chemistry, Multidisciplinary
Ke Zhang, Chao Qi, Kaiyong Cai
Summary: As an essential micronutrient, manganese (Mn) plays important roles in various physiological processes and has versatile applications in tumor immunotherapy. Mn-based nanoparticles can be used as biocompatible nanocarriers, adjuvants to regulate tumor immune microenvironment, activators of host's immune system, and contrast agents for monitoring tumor immunotherapy via MRI. This comprehensive review focuses on the recent progress, biomedical applications, challenges, and future developments of Mn-based nanoplatforms in tumor immunotherapy.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yehong Huo, Jian Hu, Yuanyuan Yin, Peng Liu, Kaiyong Cai, Wei Ji
Summary: Peptides can self-assemble into hierarchical nanostructures with excellent chemical and physical properties, making them widely applicable in bio-/nanotechnology. This review presents the latest research progress on self-assembling peptide-based nanomaterials and their applications in biomedicine and optoelectronics.
Article
Chemistry, Multidisciplinary
Tingting He, Lu Wang, Shuangquan Gou, Lu Lu, Genhua Liu, Kui Wang, Yulu Yang, Qiaojian Duan, Wenbo Geng, Peng Zhao, Zhong Luo, Kaiyong Cai
Summary: This study presents a novel approach to tumor therapy by covalently modifying probiotic Bifidobacterium bifidum (Bi) with doxorubicin (DOX)-loaded CaP/SiO2 nanoparticles (DNPs@Bi). The pH-responsive release of DOX induces chemotherapy and immunogenic cell death (ICD) in the immunosuppressive tumor microenvironment (ITME). Tumor-targeting Bi enhances the presentation of tumor-associated antigens (TAAs) to dendritic cells (DCs) via Cx43-dependent gap junctions. The combination of enhanced ICD and TAAs presentation stimulates DC maturation and cytotoxic T lymphocyte infiltration in the ITME, leading to prolonged survival rate and inhibited tumor progression and metastasis.
Article
Chemistry, Multidisciplinary
Yuxin Xing, Lin Li, Yuhua Chen, Lu Wang, Shuqi Tang, Xiyue Xie, Shuai Wang, Jixi Huang, Kaiyong Cai, Jixi Zhang
Summary: A flower-like nanozyme with highly permeable leaflets has been developed to increase the efficacy of antioxidants and antiapoptotic defense systems in therapy-resistant tumors. The nanozyme generates peroxidase/oxidase-like activities with high catalytic efficiency, leading to a robust ROS storm and rapid accumulation of oxidative damage in drug-resistant cancer cells. By combining with a redox homeostasis disrupter, a significantly high antitumor efficiency was achieved in vivo. This work provides a promising approach to ROS generators for the treatment of therapy-resistant tumors.
Article
Chemistry, Multidisciplinary
Fei Zhou, Menghuan Li, Maohua Chen, Maowen Chen, Xiaodong Chen, Zhong Luo, Kaiyong Cai, Yan Hu
Summary: The study developed a ROS-responsive micelle to deliver nanozyme and rheumatoid arthritis drug Rhein to inflamed synovial tissues and modulate the redox homeostasis in inflammatory macrophages, leading to amelioration of local inflammation and promotion of cartilage repair in rheumatoid arthritis. This approach offers alternative opportunities for the treatment of rheumatoid arthritis by reprogramming the polarization states of inflammatory macrophages through micelle-complexed biomimetic enzymes.
Article
Chemistry, Multidisciplinary
Ke Li, Kun Xu, Ye He, Yulu Yang, Meijun Tan, Yulan Mao, Yanan Zou, Qian Feng, Zhong Luo, Kaiyong Cai
Summary: In this study, a nanoreactor Cu2-xSe was developed to alleviate the intracellular hypoxia environment and enhance the catalytic and cell death-inducing activities. The nanoreactors were surface functionalized with PEG polymer and folic acid molecules to ensure in vivo blood circulation and tumor-specific uptake. The functionalized self-supplying nanoreactors demonstrated the ability to generate O2 and consume intracellular GSH through the interconversion of Cu elements, impairing the GPX4/GSH pathway and HIF-1α protein expression. Furthermore, by alleviating the intracellular hypoxia environment, the nanoreactors affected the phenotype polarization of TAMs and increased the content of IFNγ secreted by CD8+ T cells, promoting cell death induced by Erastin-loaded nanoreactors. This combined therapeutic strategy provides a potential approach for clinical application.
Article
Engineering, Biomedical
Maoyuan Sun, Yan Li, Wenli Zhang, Xiang Gu, Rong Wen, Ke Zhang, Jinning Mao, Chengyao Huang, Xiong Zhang, Mao Nie, Zhiwen Zhang, Chao Qi, Kaiyong Cai, Guodong Liu
Summary: In this study, a biomimetic nanoplatform AMNP@CLP@CCM was developed for the targeted photothermal therapy and immune checkpoint blockade (ICB) treatment of glioblastoma (GBM). The nanoplatform successfully crossed the blood-brain barrier and delivered the immune checkpoint inhibitor CLP002 to GBM tissues. The photothermal therapy not only enhanced blood-brain barrier penetration but also stimulated immunogenic cell death and T lymphocyte infiltration, resulting in significant growth inhibition of orthotopic GBM.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Multidisciplinary
Beining Yang, Fanze Meng, Jihao Zhang, Kerun Chen, Siyu Meng, Kaiyong Cai, Yanli Zhao, Liangliang Dai
Summary: The tumor microenvironment (TME) plays a crucial role in tumor occurrence, development, and metastasis. Reprogramming TME is a potential therapeutic target for effective tumor damage. Nanobiomaterials have been extensively integrated into the construction of engineered drug delivery nanosystems for TME normalization therapy.
Article
Chemistry, Multidisciplinary
Xu Zhang, Zhang Yuan, Jianshuang Wu, Ye He, Guifang Lu, Dan Zhang, Yan Zhao, Rongqian Wu, Yi Lv, Kaiyong Cai, Shuixiang He
Summary: This study introduces a nanotherapeutic approach for the targeted treatment of inflammatory bowel disease (IBD). The method uses carbon monoxide (CO) release in the inflamed colon to ameliorate inflammation and restore gut functions through multiple mechanisms. This innovative nanotherapeutic strategy holds promising potential for IBD treatment.
Article
Chemistry, Multidisciplinary
Lu Tan, Menghuan Li, Hang Chen, Yuchen Zhang, Yuan Liu, Maohua Chen, Zhong Luo, Kaiyong Cai, Yan Hu
Summary: This study proposed a composite hydrogel dressing that achieved rapid hemostasis and reduced inflammation in large bleeding wounds by loading the anti-inflammatory drug resveratrol. The hydrogel enriched blood cells and platelets around the wound area, accelerating thrombosis and reducing blood loss. The hydrogel also continuously released the drug to promote wound repair.
Article
Chemistry, Analytical
Kaifei Jin, Xiyue Xie, Jing Zhu, Zhenqiang Wang, Yuxin Xing, Lu Wang, Kaiyong Cai, Jixi Zhang
Summary: A homogeneous and label-free miRNA sensing system was developed using magnetically separable spherical nucleic acids (SNA) and signal amplification in PEC detection. The system achieved highly repeatable and anti-interference analysis of miR-21 in complex physiological samples, with a low limit of detection. It was successfully applied for sensitive profiling of miR-21 in tumor cells and tumor-bearing mice plasma.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Genhua Liu, Ruichen Ma, Peng Liu, Kui Wang, Kaiyong Cai
Summary: This study developed a multifunctional nanocomposite hydrogel system that can prevent tumor recurrence, limit bacterial infections, and promote wound healing. The system demonstrated superior photothermal effects and antioxidant properties, resulting in synergistic therapeutic effects against bacteria and tumor cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Chemistry, Physical
Xiyue Xie, Kaifei Jin, Zhenqiang Wang, Shuai Wang, Jing Zhu, Jixi Huang, Shuqi Tang, Kaiyong Cai, Jixi Zhang
Summary: In this study, an immobilization-free electrochemical sensing platform was developed to analyze up-regulated biomarkers in tumor tissues. The platform utilizes electron transfer cascade to amplify the signal output and reduce background interference, enabling accurate and quick diagnosis.
Article
Chemistry, Multidisciplinary
Xuan Li, Xinxin Luo, Ye He, Kun Xu, Yao Ding, Pengfei Gao, Bailong Tao, Meng Li, Meijun Tan, Shaopeng Liu, Peng Liu, Kaiyong Cai
Summary: Stem cell aging can affect the osteointegration effect of titanium implant, leading to its failure. Micronano titanium (MNT) can improve stem cell adhesion and osteogenic differentiation, but has minimal effects on aged stem cells. MNT induces the secretion phenotype of senescent stem cells through the activation of p38 MAPK, depleting the stem-cell pool.
Article
Biochemistry & Molecular Biology
Rong Huang, Chun-Hua Huang, Jing Chen, Zhu-Ying Yan, Miao Tang, Jie Shao, Kaiyong Cai, Ben-Zhan Zhu
Summary: Mitochondrial DNA (mtDNA) plays a critical role in cellular functions. We have discovered a new DNA probe, [Ru(phen)2dppz]Cl2, that can selectively target live-cell mtDNA and achieve in-situ self-monitoring of the apoptosis process through photo-triggered nuclear translocation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
