Article
Medicine, General & Internal
Mireia Ble, Begona Benito, Elisa Cuadrado-Godia, Silvia Perez-Fernandez, Miquel Gomez, Aleksandra Mas-Stachurska, Helena Tizon-Marcos, Lluis Molina, Julio Marti-Almor, Merce Cladellas
Summary: This study aimed to detect atrial disease in CrS patients through analyzing atrial size and function. The results showed that patients with AF had larger atrial volume and worse atrial function, with an independent association between detection of AF and atrial volume, LAEF, and strain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chia-Hung Yang, Hao-Tien Liu, Hui-Ling Lee, Fen-Chiung Lin, Chung-Chuan Chou
Summary: This study found that left atrial function plays an important role in the absence of atrial fibrillation (AF) in patients with left atrial dimension greater than or equal to 50 mm, and the late diastolic component of left atrial strain rate is the only independent variable associated with AF.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Mary Luz Mojica-Pisciotti, Roman Panovsky, Lucia Masarova, Martin Pesl, Zdenek Starek, Tomas Holecek, Vera Feitova, Lukas Opatril, Katarina Dolezalova, Vladimir Kincl
Summary: This study assessed the left atrial phasic function and deformation in paroxysmal AF patients and found that they had larger left atrial volumes, lower left atrial emptying fraction, and lower left atrial longitudinal strain compared to controls.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Mengmeng Ji, Lin He, Lang Gao, Yixia Lin, Mingxing Xie, Yuman Li
Summary: This review summarizes the recent research progress in evaluating left atrial structure and function of atrial fibrillation patients using echocardiography, as well as the role of traditional echocardiography in identifying atrial fibrillation patients at high risk of heart failure or cardiovascular death.
Article
Cardiac & Cardiovascular Systems
Antony Lurie, Jia Wang, Kyra J. Hinnegan, William F. McIntyre, Emilie P. Belley-Cote, Guy Amit, Jeff S. Healey, Stuart J. Connolly, Jorge A. Wong
Summary: This study found that the prevalence of left atrial thrombus in patients with atrial fibrillation or atrial flutter on guideline-directed anticoagulation was 2.73%. Patients with nonparoxysmal AF/AFL, undergoing cardioversion, or with CHA(2)DS(2)-VASc scores >= 3 had higher prevalence of left atrial thrombus.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Angela Zagatina, Maria Rivadeneira Ruiz, Quirino Ciampi, Karina Wierzbowska-Drabik, Jaroslaw Kasprzak, Elena Kalinina, Irina Begidova, Jesus Peteiro, Rosina Arbucci, Sofia Marconi, Jorge Lowenstein, Alla Boshchenko, Fiore Manganelli, Jelena Celutkiene, Doralisa Morrone, Elisa Merli, Federica Re, Clarissa Borguezan-Daros, Maciej Haberka, Ariel K. Saad, Ana Djordjevic-Dikic, Nithima Chaowalit Ratanasit, Fausto Rigo, Paolo Colonna, Jose Luis de Castro e Silva Pretto, Fabio Mori, Maria Grazia D'Alfonso, Miodrag Ostojic, Bojan Stanetic, Tamara Kovacevic Preradovic, Fabio Costantino, Andrea Barbieri, Rodolfo Citro, Annalisa Pitino, Mauro Pepi, Scipione Carerj, Patricia A. Pellikka, Eugenio Picano
Summary: In patients with chronic coronary syndromes, left atrial dilation and reservoir dysfunction are often present in paroxysmal and permanent atrial fibrillation. These abnormalities are associated with more frequent inducible ischemia and pulmonary congestion during stress.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Elzbieta Wabich, Agnieszka Zienciuk-Krajka, Radoslaw Nowak, Alicja Raczak, Ludmila Danilowicz-Szymanowicz
Summary: Atrial fibrillation (AF) is an important arrhythmia in hypertrophic cardiomyopathy (HCM), and the characteristics of both the left atrium (LA) and left ventricle (LV) are significant predictors for AF diagnosis in HCM patients. Global longitudinal strain (GLS) of LV may be the most accurate predictor of AF, while a combination of LA peak strain and LV GLS has the highest discriminatory power.
Article
Biology
Mattia Corti, Alberto Zingaro, Luca Dede', Alfio Maria Quarteroni
Summary: This study analyzes the hemodynamics of the left atrium, comparing differences between healthy individuals and patients with atrial fibrillation. Using patient-specific geometries, a computational simulation of blood flow dynamics in the left atria is conducted. A novel procedure for computing boundary data for 3D hemodynamic simulations is introduced, which is particularly helpful in the absence of clinical measurements. Various fluid dynamics indicators are evaluated for atrial hemodynamics and validated against clinical measurements. The impact of geometric and clinical characteristics on the risk of thrombosis is investigated, and a new indicator called "age stasis" is proposed to highlight the correlation between thrombus formation and atrial fibrillation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yameng Shao, Lei Chen, Changjiang Xu, Beibei Gao, Dongdong Zhang, Chuanyi Sang, Chaoqun Zhang
Summary: This study explored the relationship between left atrial epicardial adipose tissue (LA-EAT) and left atrial appendage flow velocity (LAA-FV) in patients with nonvalvular atrial fibrillation (NV-AF). The results showed that left atrial low voltage zone, LA-EAT volume, left atrial appendage shape, left atrial volume index, and type of atrial fibrillation were independent predictors of LAA-FV in NV-AF patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Magnus Nakrem Lyngbakken, Peter Selmer Ronningen, Magnar Gangas Solberg, Trygve Berge, Jon Brynildsen, Erika Nerdrum Aagaard, Brede Kvisvik, Helge Rosjo, Kjetil Steine, Arnljot Tveit, Torbjorn Omland
Summary: This study found that cardiac biomarkers and echocardiographic left atrial volumetric indices are associated with the prevalence and incidence of atrial fibrillation in the general population. NT-proBNP provides incremental prognostic information.
Article
Cardiac & Cardiovascular Systems
Dora Csengeri, Ngoc-Anh Sprunker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Soderberg, Steen M. Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Lochen, Frank Kee, Jukka Kontto, Ellisiv B. Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jorgensen, Kari Kuulasmaa, Tanja Zeller, Veikko Salomaa, Licia Iacoviello, Renate B. Schnabel
Summary: This study found that even modest alcohol intake (1.2 drinks/day) was associated with an increased risk of atrial fibrillation, which needs to be considered in atrial fibrillation prevention.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Agnieszka Kaplon-Cieslicka, Monika Gawalko, Monika Budnik, Beata Uzieblo-Zyczkowska, Pawel Krzesinski, Katarzyna Starzyk, Iwona Gorczyca-Glowacka, Ludmila Danilowicz-Szymanowicz, Damian Kaufmann, Maciej Wojcik, Robert Blaszczyk, Jaroslaw Hiczkiewicz, Katarzyna Lojewska, Katarzyna Mizia-Stec, Maciej T. Wybraniec, Katarzyna Kosmalska, Marcin Fijalkowski, Anna Szymanska, Miroslaw Dluzniewski, Maciej Haberka, Michal Kucio, Blazej Michalski, Karolina Kupczynska, Anna Tomaszuk-Kazberuk, Katarzyna Wilk-Sledziewska, Renata Wachnicka-Truty, Marek Kozinski, Pawel Burchardt, Piotr Scislo, Radoslaw Piatkowski, Janusz Kochanowski, Grzegorz Opolski, Marcin Grabowski
Summary: Atrial fibrillation and flutter increase the risk of left atrial thrombus. Chronic oral anticoagulation can reduce the prevalence of left atrial thrombus. The risk of left atrial thrombus appears to be higher with vitamin K antagonists compared to non-vitamin K antagonist oral anticoagulants, and similar among different non-vitamin K antagonist oral anticoagulants.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Tian, Cen Wang, Duo Gao, Bu-Lang Gao, Cai-Ying Li
Summary: This study aimed to assess the morphological and functional features of the left atrium (LA) and the left atrial appendage (LAA) in patients with atrial fibrillation (AF) using computed tomography angiography (CTA) images. The results showed that AF patients had a larger minor axis of the LAA orifice and a more circular LAA orifice compared to the control group. The LAA orifice area and perimeter were positively correlated with LAA volume change. Female patients had larger LAA orifice major and minor axes, area, perimeter, and LAA depth compared to male patients in the AF group.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Yordi J. van de Vegte, Joylene E. Siland, Michiel Rienstra, Pim van der Harst
Summary: The study found a causal association between atrial fibrillation and left atrial size and function. Atrial fibrillation was found to increase left atrial size and decrease left atrial ejection fraction, with strong influence from the AF risk allele near the PITX2 gene.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Eue-Keun Choi, So-Ryoung Lee, Hyo-Jeong Ahn, Soonil Kwon, Sunhwa Kim, Suk Ho Sohn, Jae Woong Choi, Ho Young Hwang, Seil Oh
Summary: In patients with persistent AF and a large LA, there was no significant difference in prognosis between RFCA, CBA, and thoracoscopic maze procedures. Early recurrence during the blanking period predicted late recurrence in catheter ablation, but not in thoracoscopic maze surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Jonathan B. Berlowitz, Wubin Xie, Alyssa F. Harlow, Michael J. Blaha, Aruni Bhatnagar, Emelia J. Benjamin, Andrew C. Stokes
Summary: E-cigarette use is associated with pulmonary inflammation, functional respiratory changes, and chronic lung disease. Most population-level E-cigarette research has utilized point-in-time measures of E-cigarette exposures, which may not generalize to adults who transition between cigarettes and E-cigarettes. Transitions from nonuse to exclusive E-cigarette use are associated with increased incidence rate of wheeze, while transitions from cigarettes to E-cigarettes or from dual use to E-cigarette use are associated with reduced incidence rates of wheeze and dry nighttime cough. Further research is needed to assess the risks and benefits of E-cigarette-assisted cigarette cessation.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Health Care Sciences & Services
Ludovic Trinquart, Chunyu Liu, David McManus, Christopher Nowak, Honghuang Lin, Nicole L. Spartano, Belinda Borrelli, Emelia J. Benjamin, Jonne M. Murabito
Summary: This study aimed to evaluate the impact of smartphone messaging interventions on remote transmission of blood pressure (BP) and heart rate (HR) data. The results showed that personalized notifications increased longitudinal adherence to BP and HR transmission, suggesting that personalized messaging is an effective tool in promoting adherence to mobile health systems in cardiovascular research.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, John S. Gottdiener, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, Gregory M. Marcus
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Reza Mohebi, Dongyu Wang, Emily S. Lau, Juhi K. Parekh, Norrina Allen, Bruce M. Psaty, Emelia J. Benjamin, Daniel Levy, Thomas J. Wang, Sanjiv J. Shah, John S. Gottdiener, James L. Januzzi, Jennifer E. Ho
Summary: This study compares the prevalence and prognosis of heart failure (HF) stages according to the 2013 and 2022 ACC/AHA/HFSA definitions. The new standards result in a substantial shift of individuals from stage A to stage B, and those in stage B have a higher risk of progression to symptomatic HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Computer Science, Information Systems
Carl G. Streed Jr, Dana King, Chris Grasso, Sari L. Reisner, Kenneth H. Mayer, Guneet K. Jasuja, Tonia Poteat, Monica Mukherjee, Ayelet Shapira-Daniels, Howard Cabral, Vin Tangpricha, Michael K. Paasche-Orlow, Emelia J. Benjamin
Summary: The study aims to validate an algorithm for identifying transgender and gender diverse (TGD) patients within electronic health record (EHR) data and evaluate its accuracy. The algorithm was validated in an EHR data set with self-reported gender identity using TGD-related diagnosis and procedure codes, and hormone therapy prescription data. The results showed that the algorithm had good sensitivity, specificity, positive predictive value, and negative predictive value in identifying TGD patients in administrative data. Further categorization based on prescription data also had high accuracy.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Y. Mi, Priya Gajjar, Maura E. Walker, Patricia Miller, Vanessa Xanthakis, Venkatesh L. Murthy, Martin G. Larson, Ramachandran S. Vasan, Ravi Shah, Gregory D. Lewis, Matthew Nayor
Summary: This study explores the relationship between healthy dietary patterns and physical fitness in adults, as well as the biological connections between diet and fitness through circulating metabolites. The results indicate that a healthy diet is associated with greater physical fitness in middle-aged adults, and this relationship may be explained by favorable metabolic health.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gary F. Mitchell, Jian Rong, Martin G. Larson, Leroy L. Cooper, Vanessa Xanthakis, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan
Summary: Systolic blood pressure increases with age after midlife, particularly in women, and contributes to development of wide pulse pressure hypertension in middle-aged and older adults. The relative contributions of aortic stiffness and premature wave reflection to increases in pulse pressure remain controversial.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Li, Ayana Gray, Liying Xue, Melissa G. Farb, Nir Ayalon, Charlotte Andersson, Darae Ko, Emelia J. Benjamin, Daniel Levy, Ramachandran S. Vasan, Martin G. Larson, Jian Rong, Vanessa Xanthakis, Chunyu Liu, Jessica L. Fetterman, Deepa M. Gopal
Summary: This study investigates the association between metabolomics and cardiovascular health (CVH) and finds that certain metabolites mediate the relationship between CVH and the development of atrial fibrillation (AF) and heart failure (HF).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Krishna Pundi, Gregory M. Marcus, Mintu Turakhia
Editorial Material
Cardiac & Cardiovascular Systems
Gregory M. Marcus
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel J. Tu, Celine Gallagher, Adrian D. Elliott, Kathryn E. Bradbury, Gregory M. Marcus, Dominik Linz, Bradley M. Pitman, Melissa E. Middeldorp, Jeroen M. Hendriks, Dennis H. Lau, Prashanthan Sanders, Christopher X. Wong
Summary: This study aimed to examine the associations between specific dietary patterns and incident atrial fibrillation (AF). Data from the UK Biobank were used to calculate dietary intakes and assess adherence to Mediterranean-style, Dietary Approaches to Stop Hypertension (DASH), and plant-based diets. Results showed that adherence to Mediterranean-style or DASH diets was initially associated with a lower incidence of AF, but the associations became non-significant after adjusting for lifestyle factors. Plant-based diets were not associated with AF risk. However, high ultra-processed food consumption was consistently linked to an increased risk of AF even after adjusting for confounding factors.
Editorial Material
Oncology
Gregory M. Marcus
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Judith A. Hahn, Robin Fatch, Nancy P. Barnett, Gregory M. Marcus
Summary: This study determined the optimal cutoff for phosphatidylethanol (PEth) in middle-age and older adults to detect heavy alcohol consumption, providing a reference for clinical diagnosis.