Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
出版年份 2016 全文链接
标题
Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
作者
关键词
-
出版物
Expert Review of Neurotherapeutics
Volume 17, Issue 1, Pages 59-75
出版商
Informa UK Limited
发表日期
2016-10-07
DOI
10.1080/14737175.2017.1246183
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease
- (2017) Yazhou Li et al. JOURNAL OF ALZHEIMERS DISEASE
- GLP-1 Agonists in Type 1 Diabetes Mellitus
- (2016) Kristin M. Janzen et al. ANNALS OF PHARMACOTHERAPY
- Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease
- (2016) LiMei Qin et al. Current Alzheimer Research
- The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
- (2016) Dilan Athauda et al. DRUG DISCOVERY TODAY
- Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model
- (2016) Liqin Qi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm
- (2016) Eugenio Barone et al. FREE RADICAL BIOLOGY AND MEDICINE
- In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial
- (2016) Michael Gejl et al. Frontiers in Aging Neuroscience
- Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice
- (2015) Paula L. McClean et al. BEHAVIOURAL BRAIN RESEARCH
- Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling
- (2015) Yuta Yoshino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Neuroprotective Effect of Liraglutide is Mediated by Glucagon-Like Peptide 1 Receptor-Mediated Activation of cAMP/PKA/CREB Pathway
- (2015) Yi Bao et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline
- (2015) V. A. Gault et al. DIABETES OBESITY & METABOLISM
- Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
- (2015) Volkan Solmaz et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Sitagliptin attenuated brain damage and cognitive impairment in mice with chronic cerebral hypo-perfusion through suppressing oxidative stress and inflammatory reaction
- (2015) Tzu-Hsien Tsai et al. JOURNAL OF HYPERTENSION
- Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Reduces Alzheimer Disease-Associated Tau Hyperphosphorylation in the Hippocampus of Rats With Type 2 Diabetes
- (2015) Weijie Xu et al. JOURNAL OF INVESTIGATIVE MEDICINE
- Glucagon-Like Peptide-1 Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells Under Basal and Hyperglycemia Conditions
- (2015) Shuji Fukuda et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Hippocampal insulin resistance and cognitive dysfunction
- (2015) Geert Jan Biessels et al. NATURE REVIEWS NEUROSCIENCE
- Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons
- (2015) Oliver Takach et al. NEUROBIOLOGY OF AGING
- A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis
- (2015) Sylvia Ortega-Martínez Frontiers in Molecular Neuroscience
- Aberrant insulin signaling in Alzheimer's disease: current knowledge
- (2015) Gaurav Bedse et al. Frontiers in Neuroscience
- Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain
- (2015) Simon C. Cork et al. Molecular Metabolism
- Preservation of the Blood Brain Barrier and Cortical Neuronal Tissue by Liraglutide, a Long Acting Glucagon-Like-1 Analogue, after Experimental Traumatic Brain Injury
- (2015) Jakob Hakon et al. PLoS One
- Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
- (2014) Sergio T. Ferreira et al. Alzheimers & Dementia
- The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease
- (2014) Konrad Talbot et al. Alzheimers & Dementia
- Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain
- (2014) D. Allan Butterfield et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease
- (2014) F. G. De Felice et al. DIABETES
- Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight
- (2014) Laurie L. Baggio et al. JOURNAL OF CLINICAL INVESTIGATION
- Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents
- (2014) Takashi Iwai et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial
- (2014) Kathleen M Dungan et al. LANCET
- Dementia in the developing world: risk, impact, and prevention
- (2014) Emiliano Albanese et al. NEUROBIOLOGY OF AGING
- Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease
- (2014) Paula L. McClean et al. NEUROPHARMACOLOGY
- Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice
- (2014) Rachael Lennox et al. NEUROPHARMACOLOGY
- Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism
- (2014) Nadia M. Krasner et al. PLoS One
- Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function
- (2013) Cassandra Koole et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK3β Pathway in Streptozotocin-Induced Alzheimer Rat Model
- (2013) Chong Gao et al. BRAIN PATHOLOGY
- TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
- (2013) Mychael V. Lourenco et al. Cell Metabolism
- The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?
- (2013) Stefan Trapp et al. CURRENT OPINION IN PHARMACOLOGY
- History of Medically Treated Diabetes and Risk of Alzheimer Disease in a Nationwide Case-Control Study
- (2013) A.-M. Tolppanen et al. DIABETES CARE
- Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
- (2013) Christian Hölscher JOURNAL OF ENDOCRINOLOGY
- DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
- (2013) Hiranya Pintana et al. JOURNAL OF ENDOCRINOLOGY
- Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease
- (2013) Jayasankar Kosaraju et al. NEUROPHARMACOLOGY
- Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
- (2013) Paula L. McClean et al. NEUROPHARMACOLOGY
- Role of central glucagon-like peptide-1 in stress regulation
- (2013) Sriparna Ghosal et al. PHYSIOLOGY & BEHAVIOR
- Chronic Treatment with the GLP1 Analogue Liraglutide Increases Cell Proliferation and Differentiation into Neurons in an AD Mouse Model
- (2013) Vadivel Parthsarathy et al. PLoS One
- Releasing the brake: restoring fast axonal transport in neurodegenerative disorders
- (2013) Maria-Victoria Hinckelmann et al. TRENDS IN CELL BIOLOGY
- Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals
- (2013) M Bomba et al. Cell Death & Disease
- Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
- (2013) Geert Jan Biessels et al. Lancet Diabetes & Endocrinology
- The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
- (2012) Aya Shiraki et al. ATHEROSCLEROSIS
- Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
- (2012) Kerry Hunter et al. BMC NEUROSCIENCE
- DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption
- (2012) Noppamas Pipatpiboon et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain
- (2012) Vadivel Parthsarathy et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
- (2012) David Tweedie et al. EXPERIMENTAL NEUROLOGY
- Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
- (2012) G. Cheng et al. INTERNAL MEDICINE JOURNAL
- Liraglutide, a Long-Acting GLP-1 Mimetic, and its Metabolite Attenuate Inflammation after Intracerebral Hemorrhage
- (2012) Jack Hou et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Neuroprotective actions of Glucagon-like peptide-1 in differentiated human neuroprogenitor cells
- (2012) Kalpana Velmurugan et al. JOURNAL OF NEUROCHEMISTRY
- Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice
- (2012) T. Ma et al. JOURNAL OF NEUROSCIENCE
- Insulin in the Brain: Sources, Localization and Functions
- (2012) Rasoul Ghasemi et al. MOLECULAR NEUROBIOLOGY
- Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures
- (2012) Dong-Hou Kim et al. NEUROBIOLOGY OF DISEASE
- The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease
- (2012) Caitriona M. Long-Smith et al. NEUROMOLECULAR MEDICINE
- Axonal transport and neurodegenerative disease: Can we see the elephant?
- (2012) Lawrence S.B. Goldstein PROGRESS IN NEUROBIOLOGY
- Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4
- (2011) Song Chen et al. AGE
- Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion
- (2011) Woo-Jin Song et al. Cell Metabolism
- Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
- (2011) Mireille Bélanger et al. Cell Metabolism
- Neuroprotective properties of GLP-1: theoretical and practical applications
- (2011) Jens Juul Holst et al. CURRENT MEDICAL RESEARCH AND OPINION
- (Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
- (2011) Lin Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation
- (2011) Cassandra Koole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease
- (2011) P. L. McClean et al. JOURNAL OF NEUROSCIENCE
- Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
- (2011) A. Hamilton et al. JOURNAL OF NEUROSCIENCE RESEARCH
- GLP-1 and energy balance: an integrated model of short-term and long-term control
- (2011) Jason G. Barrera et al. Nature Reviews Endocrinology
- Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation
- (2011) Daisuke Yabe et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- GLP-1-derived nonapeptide GLP-1(28–36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes
- (2011) Eva Tomas et al. REGULATORY PEPTIDES
- Incretin-Based Therapies for Type 2 Diabetes Mellitus: Properties, Functions, and Clinical Implications
- (2010) Michael A. Nauck AMERICAN JOURNAL OF MEDICINE
- Glucagon-like peptide 1 and the brain: Central actions–central sources?
- (2010) Stefan Trapp et al. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
- Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model
- (2010) Paola Luciani et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Building Genetic Scores to Predict Risk of Complex Diseases in Humans: Is It Possible?
- (2010) S. Liu et al. DIABETES
- Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review
- (2010) C. F. Deacon DIABETES OBESITY & METABOLISM
- The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
- (2010) Ruben Isacson et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Serotonin syndrome in an orthopaedic patient secondary to linezolid therapy for MRSA infection
- (2010) M. McClean et al. IRISH JOURNAL OF MEDICAL SCIENCE
- Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
- (2010) Simon Gengler et al. NEUROBIOLOGY OF AGING
- Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study
- (2010) E. M. C. Schrijvers et al. NEUROLOGY
- Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
- (2010) X.H. Wang et al. NEUROSCIENCE
- Chronic treatment of exendin-4 affects cell proliferation and neuroblast differentiation in the adult mouse hippocampal dentate gyrus
- (2010) Hua Li et al. NEUROSCIENCE LETTERS
- Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
- (2010) Niels Vrang et al. PROGRESS IN NEUROBIOLOGY
- Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
- (2009) Talib Abbas et al. BEHAVIOURAL BRAIN RESEARCH
- Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders
- (2009) Louis A. Profenno et al. BIOLOGICAL PSYCHIATRY
- Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats
- (2009) Holger Fuchs et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Pharmacokinetics of the Dipeptidyl Peptidase 4 Inhibitor Saxagliptin in Rats, Dogs, and Monkeys and Clinical Projections
- (2009) A. Fura et al. DRUG METABOLISM AND DISPOSITION
- Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
- (2009) Paula L. McClean et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer’s prone mice
- (2009) Michele D’Amico et al. EXPERIMENTAL GERONTOLOGY
- Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons
- (2009) Denise D. Belsham et al. FASEB JOURNAL
- Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
- (2009) Alison Hamilton et al. NEUROREPORT
- Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway
- (2009) R. Kimura et al. NEUROSCIENCE
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
- (2009) Fernanda G. De Felice et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes
- (2008) J.-F. Gautier et al. DIABETES & METABOLISM
- GLP-1 receptor signaling: effects on pancreatic β-cell proliferation and survival
- (2008) J. Buteau DIABETES & METABOLISM
- Low, but Physiological, Concentration of GLP-1 Stimulates Insulin Secretion Independent of the cAMP-Dependent Protein Kinase Pathway
- (2008) Makoto Shigeto et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Nutritional regulation of glucagon-like peptide-1 secretion
- (2008) Gwen Tolhurst et al. JOURNAL OF PHYSIOLOGY-LONDON
- New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer’s disease?
- (2008) Christian Hölscher et al. NEUROBIOLOGY OF AGING
- Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease
- (2007) Göran Bertilsson et al. JOURNAL OF NEUROSCIENCE RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now