Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus

(2016) Kensuke Suzuki et al.   BMC CANCER

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Increased 5-hydroxymethylcytosine in CD4 + T cells in systemic lupus erythematosus

(2016) Ming Zhao et al.   JOURNAL OF AUTOIMMUNITY

Coexistence of systemic lupus erythematosus, tuberous sclerosis and aggressive natural killer-cell leukaemia: coincidence or correlated?

(2016) M Olde Bekkink et al.   LUPUS

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

Cellular and metabolic requirements of effector T cells

(2016) George C. Tsokos   Nature Reviews Rheumatology

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

(2015) Qingyu Zeng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome

(2015) Zhi-wei Lai et al.   CLINICAL IMMUNOLOGY

Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus

(2015) Yuxin Liu et al.   CLINICAL IMMUNOLOGY

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

(2015) Kenji Ichiyama et al.   IMMUNITY

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

(2015) Andras Perl et al.   Metabolomics

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus

(2015) Shuangyan Luo et al.   Clinical Epigenetics

Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus

(2015) Nils Rother et al.   Frontiers in Immunology

The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production

(2014) Toshihiko Kobayashi et al.   IMMUNITY

Dysregulation of anergy-related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in restoring regulatory T cells

(2014) Leontina M. Banica et al.   International Journal of Rheumatic Diseases

Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer

(2014) Vijayalekshmi Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

(2014) Tomohiro Koga et al.   JOURNAL OF CLINICAL INVESTIGATION

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Akt-Dependent Enhanced Migratory Capacity of Th17 Cells from Children with Lupus Nephritis

(2014) Sudhir Kshirsagar et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome

(2014) Guillaume Canaud et al.   NEW ENGLAND JOURNAL OF MEDICINE

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

(2014) Satomi Miwa et al.   Nature Communications

Prevention of Murine Lupus Nephritis by Targeting Multiple Signaling Axes and Oxidative Stress Using a Synthetic Triterpenoid

(2014) Tianfu Wu et al.   Arthritis & Rheumatology

Structure and Function of Renal Macrophages and Dendritic Cells From Lupus-Prone Mice

(2014) Ranjit Sahu et al.   Arthritis & Rheumatology

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

(2013) Tiffany N Caza et al.   ANNALS OF THE RHEUMATIC DISEASES

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

(2013) Li Zhang et al.   CLINICAL IMMUNOLOGY

hsBAFF promotes proliferation and survival in cultured B lymphocytes via calcium signaling activation of mTOR pathway

(2013) Zhen Ke et al.   CYTOKINE

Rapamycin unbalances the polarization of human macrophages to M1

(2013) Alessia Mercalli et al.   IMMUNOLOGY

Tuberous Sclerosis and Fulminant Lupus in a Young Woman

(2013) Namrata Singh et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells

(2013) Y. Ding et al.   JOURNAL OF IMMUNOLOGY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

CMV Late Phase-Induced mTOR Activation Is Essential for Efficient Virus Replication in Polarized Human Macrophages

(2012) M. Poglitsch et al.   AMERICAN JOURNAL OF TRANSPLANTATION

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Aberrant Macrophages Mediate Defective Kidney Repair That Triggers Nephritis in Lupus-Susceptible Mice

(2012) Y. Iwata et al.   JOURNAL OF IMMUNOLOGY

Proliferation signal inhibitors in the treatment of lupus nephritis: Preliminary experience

(2012) DESMOND YH YAP et al.   NEPHROLOGY

Metabolic Alterations and Increased Liver mTOR Expression Precede the Development of Autoimmune Disease in a Murine Model of Lupus Erythematosus

(2012) Laia Vilà et al.   PLoS One

Immunologic characteristics of intrarenal T cells: Trafficking of expanded CD8+ T cell β-chain clonotypes in progressive lupus nephritis

(2011) Robert Winchester et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice

(2008) SL Lui et al.   LUPUS