The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis

Perioperative Statins in Cardiac Surgery and Acute Kidney Injury

(2016) Rinaldo Bellomo   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Endothelial cell-specific molecule–1/endocan: Diagnostic and prognostic value in patients suffering from severe sepsis and septic shock

(2016) Dominic Pauly et al.   JOURNAL OF CRITICAL CARE

Advances in Sepsis Research

(2015) Peter Bentzer et al.   CLINICS IN CHEST MEDICINE

Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients

(2015) Aurore Palud et al.   CYTOKINE

Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes

(2015) Lukas Martin et al.   SHOCK

Inflammation-Induced Increases in Plasma Endocan Levels are Associated With Endothelial Dysfunction in Humans in vivo

(2015) Laura AE Cox et al.   SHOCK

Antimicrobial Peptides in Human Sepsis

(2015) Lukas Martin et al.   Frontiers in Immunology

Characteristics of Serum Endocan Levels in Infection

(2015) Kazunori Seo et al.   PLoS One

Peptide 19-2.5 Inhibits Heparan Sulfate-Triggered Inflammation in Murine Cardiomyocytes Stimulated with Human Sepsis Serum

(2015) Lukas Martin et al.   PLoS One

The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis

(2015) Lukas Martin et al.   PLoS One

The endothelial glycocalyx: a review of the vascular barrier

(2014) C. S. Alphonsus et al.   ANAESTHESIA

Albumin Replacement in Patients with Severe Sepsis or Septic Shock

(2014) Pietro Caironi et al.   NEW ENGLAND JOURNAL OF MEDICINE

N-Acetyl-Heparin Attenuates Acute Lung Injury Caused by Acid Aspiration Mainly by Antagonizing Histones in Mice

(2014) Yanlin Zhang et al.   PLoS One

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

Choices in fluid type and volume during resuscitation: impact on patient outcomes

(2014) Alena Lira et al.   Annals of Intensive Care

Circulating glycosaminoglycan species in septic shock

(2013) A. NELSON et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors

(2013) Lena Heinbockel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis: A prospective study

(2013) Sisse R. Ostrowski et al.   JOURNAL OF CRITICAL CARE

Versatile role of heparanase in inflammation

(2013) Rachel Goldberg et al.   MATRIX BIOLOGY

Resuscitation Fluids

(2013) John A. Myburgh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

A New Class of Synthetic Peptide Inhibitors Blocks Attachment and Entry of Human Pathogenic Viruses

(2012) Marcel Krepstakies et al.   JOURNAL OF INFECTIOUS DISEASES

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Vascular adhesion protein-1 and syndecan-1 in septic shock

(2011) M. SALLISALMI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Systemic Steroids in Severe Sepsis and Septic Shock

(2011) Gourang P. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Release of atrial natriuretic peptide precedes shedding of the endothelial glycocalyx equally in patients undergoing on- and off-pump coronary artery bypass surgery

(2011) Dirk Bruegger et al.   BASIC RESEARCH IN CARDIOLOGY

Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion

(2011) T. Annecke et al.   BRITISH JOURNAL OF ANAESTHESIA

Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*

(2011) Daniel R. Ricciuto et al.   CRITICAL CARE MEDICINE

The effect of inflammation on coagulation and vice versa

(2011) Tom van der Poll et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels

(2011) Itay Shafat et al.   PLoS One

New Antiseptic Peptides To Protect against Endotoxin-Mediated Shock

(2010) T. Gutsmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential

(2010) B. F. Becker et al.   CARDIOVASCULAR RESEARCH

Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan

(2010) S. Sarrazin et al.   GLYCOBIOLOGY

Angiopoietin-2 is increased in septic shock: Evidence for the existence of a circulating factor stimulating its release from human monocytes

(2009) Hariklia Kranidioti et al.   IMMUNOLOGY LETTERS

Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix

(2009) Jochen Steppan et al.   JOURNAL OF SURGICAL RESEARCH

ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS

(2009) Jonathan M. Siner et al.   SHOCK

Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease

(2008) Lysette N Broekhuizen et al.   CURRENT OPINION IN LIPIDOLOGY