Article
Engineering, Environmental
Qian Li, Guofu Zhang, Lixia Lin, Meng Wu, Xiyu Cao, Daxiang Xiao, Xiaoyi Wang, Xu Zhang, Shangzhi Xu, Xiating Li, Chunrong Zhong, Tianqi Tan, Xi Chen, Li Huang, Yu Zhang, Renjuan Chen, Xuezhen Zhou, Ting Xiong, Yuanjue Wu, Qin Gao, Jiangyue Wu, De Li, Wenli Cui, Menghan Tu, Huaqi Zhang, Siyu Yang, Jin Liu, Hongying Yang, Xuefeng Yang, Liping Hao, Nianhong Yang
Summary: This study found that higher plasma Mn levels in early pregnancy are associated with increased risk of gestational diabetes mellitus (GDM).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoxia Duan, Zhenhua Chen, Congying Xia, Rong Zhong, Li Liu, Lu Long
Summary: This study shows a significant association between exposure to ambient VOCs and an increased risk of diabetes and impaired glucose homeostasis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Virology
Luz E. Cabrera, Constanze Schmotz, Moin A. Saleem, Sanna Lehtonen, Olli Vapalahti, Antti Vaheri, Satu Makela, Jukka Mustonen, Tomas Strandin
Summary: This study found that HPSE levels in urine were significantly increased during the acute phase of HFRS and strongly associated with kidney injury and disease severity. Furthermore, increased expression of HPSE was detected in orthohantavirus-infected podocytes. These findings suggest that HPSE may play a role in disrupting the endothelial glycocalyx in the kidneys of orthohantavirus-infected patients, leading to proteinuria.
Article
Endocrinology & Metabolism
Weijia Xie, Na Wu, Bin Wang, Yu Xu, Yao Zhang, Ying Xiang, Wenjing Zhang, Zheng Chen, Zhiquan Yuan, Chengying Li, Xiaoyue Jia, Yifan Shan, Bin Xu, Li Bai, Li Zhong, Yafei Li
Summary: The study aimed to investigate the impact of Fasting Plasma Glucose (FPG) and glucose fluctuation on the prognosis of COVID-19 patients, stratified by pre-existing diabetes. Results showed that hyperglycemia and glucose fluctuation were adverse prognostic factors of COVID-19, emphasizing the importance of glycemic control in therapeutic management.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Jane Vermunt, Fiona Bragg, Jim Halsey, Ling Yang, Yiping Chen, Yu Guo, Huaidong Du, Fanwen Meng, Pei Pei, Canqing Yu, Jun Lv, Junshi Chen, Liming Li, Sarah Lewington, Zhengming Chen
Summary: Among Chinese adults without diabetes, higher usual random plasma glucose levels were associated with increased mortality risks from several major diseases, with no apparent thresholds below the cut-points for diabetes diagnosis.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Cell Biology
Els Beijer, Claudia Roodenburg-Benschop, Milou C. Schimmelpennink, Jan C. Grutters, Bob Meek, Marcel Veltkamp
Summary: Elevated levels of Serum Amyloid A (SAA) were found in patients with sarcoidosis, especially those with fibrotic sarcoidosis, and in patients with idiopathic pulmonary fibrosis (IPF). This suggests that SAA may not only be involved in granulomatous processes, but also reflect fibrogenesis. Further studies are needed to clarify the exact role of SAA in fibrosis and the mechanisms involved.
Article
Medicine, Research & Experimental
Nicole N. Noren Hooten, Nicolle A. A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. B. Zonderman, Ngozi Ezike, Mark J. J. DiNubile, Susan K. L. Levinson, Michele K. K. Evans
Summary: This study found differences in plasma gelsolin levels among individuals with and without diabetes, and these differences were associated with sex, race, and poverty. Additionally, gelsolin was significantly associated with adiponectin, an adipokine, and other inflammation- and diabetes-related proteins. These findings provide mechanistic insights into the relationship between gelsolin and diabetes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Wenjun Wang, Zhonglin Chai, Mark E. Cooper, Paul Z. Zimmet, Hua Guo, Junyu Ding, Feifei Yang, Xixiang Lin, Xu Chen, Xiao Wang, Qin Zhong, Zongren Li, Peifang Zhang, Zhenzhou Wu, Xizhou Guan, Lei Zhang, Kunlun He
Summary: This study found that elevated fasting blood glucose levels are associated with increased clinical severity in COVID-19 patients. COVID-19 patients are more sensitive to fasting blood glucose levels and experience more severe clinical complications compared to other pneumonia patients.
Article
Endocrinology & Metabolism
Hua Hu, Meng Zhao, Zhaoyang Li, Hongli Nie, Jia He, Zhuo Chen, Jing Yuan, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study explored the differentially expressed miRNAs in type 2 diabetes and their potential cellular functions. It was found that miR-193b-3p expression increased in type 2 diabetes cases while TPI1 expression decreased. miR-193b-3p may affect glucose metabolism by inhibiting insulin receptor and GLUT2 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Hematology
Alicia S. Eustes, Robert A. Campbell, Elizabeth A. Middleton, Neal D. Tolley, Bhanu K. Manne, Emilie Montenont, Jesse W. Rowley, Krystin Krauel, Antoinette Blair, Li Guo, Yasuhiro Kosaka, Isabel M. Medeiros-de-Moraes, Marcus Lacerda, Eugenio D. Hottz, Hugo Castro Faria Neto, Guy A. Zimmerman, Andrew S. Weyrich, Aaron Petrey, Matthew T. Rondina
Summary: During clinical sepsis, translation and enzymatic activity of HPSE are increased in platelets. Increased expression of the active form of HPSE protein is associated with sepsis-associated mortality.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medical Laboratory Technology
Geronimo Heilmann, Sandra Trenkamp, Clara Moeser, Maria Bombrich, Martin Schoen, Iryna Yurchenko, Klaus Strassburger, Marcos Matabuena Rodriguez, Oana-Patricia Zaharia, Volker Burkart, Robert Wagner, Michael Roden
Summary: Objectives of this study were to compare glucose measurements in sodium fluoride (NaF)-citrate plasma and venous whole blood and estimate the impact of these differences on diabetes and prediabetes prevalence. The study found that even with the recommended conversion factor, the glucose concentration difference remained higher in NaF-citrate plasma. This systematic bias of glucose measurements due to sampling type leads to clinically relevant higher estimates of diabetes and prediabetes prevalence.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Justyna Modrzynska, Christine F. Klein, Kasper Iversen, Henning Bundgaard, Bolette Hartmann, Maike Mose, Nikolaj Rittig, Niels Moller, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Summary: The study indicated that glucagon concentrations increase during inflammation, while GLP-1 concentrations remain stable. Additionally, acute systemic inflammation results in elevated glucagon levels, which may contribute to impaired glucose control in patients with systemic inflammatory diseases.
ENDOCRINE CONNECTIONS
(2021)
Article
Neurosciences
Anna K. Edlund, Kewei Chen, Wendy Lee, Hillary Protas, Yi Su, Eric Reiman, Richard Caselli, Henrietta M. Nielsen
Summary: The study found that in APOE ε3/ε4 individuals, lower plasma apoE3 levels were associated with higher plasma glucose levels, and higher glucose levels were negatively correlated with cerebral glucose metabolism rate, which in turn negatively affected neuropsychological test scores. These findings suggest that a combination of high glucose levels and low apoE levels may pose a risk for developing AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Physiology
Jiehui Sun, Keqin Han, Miao Xu, Lujuan Li, Jin Qian, Li Li, Xuejin Li
Summary: Experimental data showed that there is not a clear correlation between blood viscosity and HbA(1c) levels in patients with Type 2 Diabetes Mellitus, but a significant positive correlation with plasma fibrinogen levels. Additionally, factors such as increased blood hematocrit, enhanced red blood cell aggregation, and reduced RBC deformation play key roles in determining blood viscosity in T2DM.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ji-Hee Haam, Young-Sang Kim, Doo-Yeoun Cho, Hyejin Chun, Sang-Woon Choi, Yun Kyong Lee, Sang Wook Lim, Hyung Suk Koo, Moon Jong Kim
Summary: Recent evidence suggests that cellular perturbations may play a role in the pathogenesis of cardiovascular diseases. A study involving 330 Korean men and women found a correlation between levels of urinary metabolites and arterial stiffness, with certain metabolites independently associated with brachial-ankle pulse wave velocity regardless of conventional cardiovascular risk factors. This suggests that metabolic disturbances in cells may be related to arterial stiffness.
SCIENTIFIC REPORTS
(2021)