Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling

The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration

(2016) A E Hall et al.   Cell Death & Disease

Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration

(2016) Zhihai Zhao et al.   Biology Open

p53 regulates cytoskeleton remodeling to suppress tumor progression

(2015) Keigo Araki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The mechanotransduction machinery at work at adherens junctions

(2015) B. Ladoux et al.   Integrative Biology

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

Mutant p53 promotes ovarian cancer cell adhesion to mesothelial cells via integrin β4 and Akt signals

(2015) Jong-Gyu Lee et al.   Scientific Reports

Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion

(2014) J. Kim et al.   EMBO REPORTS

p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion

(2014) Shota Yamauchi et al.   JOURNAL OF CELL BIOLOGY

Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers

(2014) A. R. Harris et al.   JOURNAL OF CELL SCIENCE

Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis

(2014) Antti Arjonen et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Mitotic Cytoskeleton Dynamics and Cytokinesis by Integrin-Linked Kinase in Retinoblastoma Cells

(2014) William K. A. Sikkema et al.   PLoS One

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

Contribution of p53 to Metastasis

(2014) E. Powell et al.   Cancer Discovery

Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells

(2013) Hana Janouskova et al.   CANCER LETTERS

Mechanosensitive systems at the cadherin-F-actin interface

(2013) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Loss of p53 Enhances NF-κB-Dependent Lamellipodia Formation

(2013) Alvin Kunyao Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors

(2013) B E Engel et al.   Cell Death & Disease

Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

(2013) Keigo Araki et al.   eLife

Requirement of LIM domains for the transient accumulation of paxillin at damaged stress fibres

(2013) T. Watanabe-Nakayama et al.   Biology Open

p130Cas-dependent actin remodelling regulates myogenic differentiation

(2012) Keiko Kawauchi et al.   BIOCHEMICAL JOURNAL

Integrin  5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

(2012) H. Janouskova et al.   CANCER RESEARCH

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death

(2012) Magali Castells et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Cadherin-11, a Marker of the Mesenchymal Phenotype, Regulates Glioblastoma Cell Migration and Survival In Vivo

(2012) H. Kaur et al.   MOLECULAR CANCER RESEARCH

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Interaction of tumor cells with the microenvironment

(2011) Hendrik Ungefroren et al.   Cell Communication and Signaling

Beyond focal adhesions: Integrin linked kinase associates with tubulin and regulates mitotic spindle organization

(2011) Andrew B. Fielding et al.   CELL CYCLE

Newly identified aspects of tumor suppression by RB

(2011) P. Viatour et al.   Disease Models & Mechanisms

Mutant p53 Disrupts MCF-10A Cell Polarity in Three-dimensional Culture via Epithelial-to-mesenchymal Transitions

(2011) Yanhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin

(2011) Juhui Qiu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

(2011) S Floor et al.   ONCOGENE

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells

(2010) I Kogan-Sakin et al.   CELL DEATH AND DIFFERENTIATION

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

(2010) Daniel R Croft et al.   CELL RESEARCH

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion

(2010) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of actin cytoskeleton dynamics in cells

(2010) Sung Haeng Lee et al.   MOLECULES AND CELLS

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

(2010) A B Fielding et al.   ONCOGENE

A Role for the Retinoblastoma Protein As a Regulator of Mouse Osteoblast Cell Adhesion: Implications for Osteogenesis and Osteosarcoma Formation

(2010) Bernadette Sosa-García et al.   PLoS One

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

The structure of the ankyrin-binding site of  -spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties

(2009) P. R. Stabach et al.   BLOOD

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Negative Regulation of  4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression

(2009) G. Bon et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Enhancer of Polycomb1 Acts on Serum Response Factor to Regulate Skeletal Muscle Differentiation

(2009) Ju-Ryoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon

(2009) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway

(2009) C Tanikawa et al.   ONCOGENE

Involvement of Members of the Cadherin Superfamily in Cancer

(2009) G. Berx et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling

(2008) Alok Sharma et al.   BMC CELL BIOLOGY

The Mammary Progenitor Marker CD61/ 3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis

(2008) F. Vaillant et al.   CANCER RESEARCH

Lamellipodia and filopodia in metastasis and invasion

(2008) Laura M. Machesky   FEBS LETTERS

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Migratory neighbors and distant invaders: tumor-associated niche cells

(2008) J. Wels et al.   GENES & DEVELOPMENT

Cell Adhesion-dependent Cofilin Serine 3 Phosphorylation by the Integrin-linked Kinase·c-Src Complex

(2008) Yong-Bae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Cadherin-11 Promotes the Metastasis of Prostate Cancer Cells to Bone

(2008) K. Chu et al.   MOLECULAR CANCER RESEARCH

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY