Article
Oncology
Qilong Ma, Dinghao Zhuo, Feng Guan, Xiang Li, Xiaomin Yang, Zengqi Tan
Summary: The study found that GM1-enriched sEVs derived from breast cancer cells can induce the epithelial-mesenchymal transition (EMT) process in recipient cells. Proteomic analysis revealed differentially expressed proteins related to sEV secretion and identified oncogenic differentially expressed proteins presented in sEVs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Sergio Simoes, Gerald Lerchbaumer, Milena Pellikka, Paraskevi Giannatou, Thomas Lam, Dohyun Kim, Jessica Yu, David ter Stal, Kenana Al Kakouni, Rodrigo Fernandez-Gonzalez, Ulrich Tepass
Summary: Most forms of cancer involve the movement of cells out of an epithelial layer, a process that requires the loss of apical polarity. This study reveals the regulatory role of key polarity proteins in this loss of polarity. The dynamic regulation of the apical Crumbs polarity complex is crucial for normal neural stem cell ingression.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Oleg Semenov, Alexandra Daks, Olga Fedorova, Oleg Shuvalov, Nickolai A. Barlev
Summary: The aberrantly activated EMT program plays a central role in defining the critical features of aggressive carcinomas, and the p53 gene is critical for suppressing these features. Specific mutations in the p53 gene can convert it into an oncogene. This review contrasts the different regulatory roles of wild-type and mutant p53 in the process of EMT.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Thomas Legier, Diane Rattier, Jack Llewellyn, Thomas Vannier, Benoit Sorre, Flavio Maina, Rosanna Dono
Summary: Fate specification in the mammalian epiblast relies on complex interactions between morphogens and tissue organization. This study highlights epithelial integrity as a key determinant of TGF-beta activity and a mechanism guiding morphogen sensing and spatial cell fate change. These findings reveal that epithelial integrity is a key determinant of TGF-beta activity and highlight an additional mechanism guiding morphogen sensing and spatial cell fate change within an epithelium.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Pengfei Lu, Yunzhe Lu
Summary: Epithelium is traditionally considered an immotile tissue, but recent research has shown that it is actually more motile than previously thought. Epithelial-mesenchymal transition (EMT) is a crucial process for embryonic development, organ formation, and cancer metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Bhuminder Singh, Galina Bogatcheva, Evan Krystofiak, Eliot T. McKinley, Salisha Hill, Kristie Lindsey Rose, James N. Higginbotham, Robert J. Coffey
Summary: This study demonstrates that induction of apical mistrafficking of Y156A EREG can lead to the formation of ectopic lumens in fully formed MDCK cysts, involving metalloprotease-mediated cleavage of EREG and subsequent EGFR activity.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Nuno Vale, Sara Silva, Diana Duarte, Diana M. A. Crista, Luis Pinto da Silva, Joaquim C. G. Esteves da Silva
Summary: Three different C-dots were prepared using the same carbon and nitrogen precursors and tested for safety against the human normal breast cell line MCF-10A. Results showed similarity in size and composition for all C-dots, with hydrothermal-based C-dots showing the most promising viability profile in the MCF-10A cells after 72 hours of treatment. These C-dots have potential applications in biomedicine as imaging agents or drug carriers.
RSC MEDICINAL CHEMISTRY
(2021)
Article
Biology
Maia Al-Masri, Karina Paliotti, Raymond Tran, Ruba Halaoui, Virginie Lelarge, Sudipa Chatterjee, Li-Ting Wang, Christopher Moraes, Luke McCaffrey
Summary: The study found that cancer cells cultured in flat environments primarily rely on oxidative phosphorylation for high energy production and depend on glucose and glutamine for growth, while cells in organotypic culture show lower energy levels and metabolic plasticity to maintain growth during glucose or amino acid deprivation. The mechanical properties were identified to control metabolic plasticity, correlating with canonical Wnt signaling.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cristian A. Vergara-Geronimo, Alfonso Leon-Del-Rio, Mauricio Rodriguez-Dorantes, Rafael Camacho-Carranza, Patricia Ostrosky-Wegman, Ana Maria Salazar
Summary: Arsenic is associated with the development of breast cancer, potentially through interaction with zinc finger motifs in proteins. We found that arsenic can reduce the levels of GATA3 protein, leading to increased cell proliferation and migration, ultimately affecting the development of breast cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Cell Biology
Sun -Young Lee, Claire Robertson, Alexandra Diot, Valerie Meuray, Jean-Christophe Bourdon, Mina J. Bissell
Summary: Growing evidence suggests that p53 has a crucial role in tissue development. The A133p53 isoforms respond to laminin-111 and play a regulatory role in mammary organoid formation along with p53 alpha. Dysregulation of A133p53 leads to changes in gene expression and cell behavior in breast epithelial cells.
JOURNAL OF CELL SCIENCE
(2023)
Article
Genetics & Heredity
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri
Summary: Lipid species have diverse biological functions based on structural differences, some of which interact with proteins as second messengers. The accumulation of phospholipid mediator PAF in the tumor microenvironment disrupts cellular homeostasis and increases metastatic potential.
FRONTIERS IN GENETICS
(2021)
Review
Genetics & Heredity
Ling Li, Jinxia Zheng, Sebastian Oltean
Summary: This article discusses the role of alternative splicing (AS) in the regulation of epithelial-mesenchymal transition (EMT) and suggests that reversing or inhibiting EMT may provide new therapeutic strategies for suppressing tumor cell migration and metastasis.
Article
Nutrition & Dietetics
Homa Hajimehdipoor, Zahra Tahmasvand, Fatemeh Ghorban Nejad, Marc Maresca, Sadegh Rajabi
Summary: This study investigated the effects of rutin on the proliferation, metastasis, and angiogenesis of breast cancer cells. Rutin was found to stimulate the proliferation and migration of MDA-MB-231 and MCF-7 cells. It also modulated the expression of genes involved in cell adhesion and angiogenesis.
Article
Biochemistry & Molecular Biology
Tugba H. Altunok, Robertino J. Muchut, Alberto A. Iglesias, Abdullah Yalcin
Summary: TGFβ1 induces the expression of PFKFB4 and PFKFB4 plays a critical role in TGFβ1-driven phenotypes such as EMT and cell invasion.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Biochemistry & Molecular Biology
Tsui-Hwa Tseng, Yi-Chia Shao, Yean-Jang Lee, Huei-Jane Lee
Summary: In this study, the benzofuran derivative BMBF was found to have anti-metastatic effects in hepatocellular carcinoma (HCC). BMBF suppressed HCC cell proliferation, altered cell morphology, and inhibited cell motility and migration. Additionally, BMBF regulated the expression of proteins associated with epithelial-mesenchymal transition (EMT) and metastasis, such as E-cadherin, vimentin, Slug, and MMP9.