Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection

A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

(2015) Aran Singanayagam et al.   CLINICAL SCIENCE

Immune Surveillance by Rhinovirus-Specific Circulating CD4+ and CD8+ T Lymphocytes

(2015) John W. Steinke et al.   PLoS One

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma ExacerbationsIn Vivo

(2014) David J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection

(2014) A Jayaraman et al.   Mucosal Immunology

Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance

(2014) Fang Yu et al.   NATURE IMMUNOLOGY

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

IL-17A Induces Signal Transducers and Activators of Transcription–6–Independent Airway Mucous Cell Metaplasia

(2013) Dawn C. Newcomb et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protective and dysregulated T cell immunity in RSV infection

(2013) Peter J Openshaw et al.   Current Opinion in Virology

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

(2013) Nicholas Glanville et al.   PLoS Pathogens

Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1

(2012) Gary R. McLean et al.   ANTIVIRAL RESEARCH

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

(2012) Nathan W. Bartlett et al.   EMBO Molecular Medicine

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

(2012) Scott M. Gordon et al.   IMMUNITY

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

(2012) Aditi Kanhere et al.   Nature Communications

Rhinovirus induces MUC5AC in a human infection model and in vitro via NF- B and EGFR pathways

(2010) C. A. Hewson et al.   EUROPEAN RESPIRATORY JOURNAL

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

(2010) Louise Slater et al.   PLoS Pathogens

Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease

(2009) Maria Semitekolou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Allergen-Induced Airway Inflammation in the Absence of T-bet Regulation Is Dependent on IL-17

(2009) D. M. Durrant et al.   JOURNAL OF IMMUNOLOGY

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

(2008) S. D. Message et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA