The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

NFAT Targets Signaling Molecules to Gene Promoters in Pancreatic β-Cells

(2015) Michael C. Lawrence et al.   MOLECULAR ENDOCRINOLOGY

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

Using Galaxy-P to leverage RNA-Seq for the discovery of novel protein variations

(2014) Gloria M Sheynkman et al.   BMC GENOMICS

Postnatal β-Cell Proliferation and Mass Expansion Is Dependent on the Transcription Factor Nkx6.1

(2014) Brandon L. Taylor et al.   DIABETES

Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in  -Cell Regeneration Research

(2014) A. F. Stewart   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

β-Cell Proliferation After a Partial Pancreatectomy Is Independent of IRS-2 in Mice

(2014) Yu Togashi et al.   ENDOCRINOLOGY

The diabetes gene Hhex maintains  -cell differentiation and islet function

(2014) J. Zhang et al.   GENES & DEVELOPMENT

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Nkx6.1 regulates islet  -cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

(2014) J. S. Tessem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies

(2014) Kevin J. Basile et al.   International Journal of Endocrinology

EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments

(2013) Ning Leng et al.   BIOINFORMATICS

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

Count-based differential expression analysis of RNA sequencing data using R and Bioconductor

(2013) Simon Anders et al.   Nature Protocols

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets

(2012) Zhidong Tu et al.   PLoS Genetics

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca 2+ -Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

(2011) Damien Demozay et al.   DIABETES

Transgenic Overexpression of the Transcription Factor Nkx6.1 in β-Cells of Mice Does Not Increase β-Cell Proliferation, β-Cell Mass, or Improve Glucose Clearance

(2011) Ashleigh E. Schaffer et al.   MOLECULAR ENDOCRINOLOGY

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation

(2010) Tomas Babak et al.   BMC GENOMICS

An improved technique for calculating relative response in cellular proliferation experiments

(2010) Mark E. Munson   CYTOMETRY PART A

Genetics of type 2 diabetes: pathophysiologic and clinical relevance

(2010) Christian Herder et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-α Gene Expression in Pancreatic Islet Endocrine Cells

(2010) Michael C. Lawrence et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcineurin Signaling Regulates Human Islet β-Cell Survival

(2010) Scott A. Soleimanpour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

(2008) M. P. Keller et al.   GENOME RESEARCH

Alternative splicing and expression of human and mouse NFAT genes

(2008) Hanna Vihma et al.   GENOMICS

Stimulation of Human and Rat Islet  -Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1

(2008) J. C. Schisler et al.   MOLECULAR AND CELLULAR BIOLOGY

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

(2008) Andreia S. Bernardo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS