Article
Oncology
Arantza Infante, Blanca Gener, Miguel Vazquez, Nerea Olivares, Arantza Arrieta, Gema Grau, Isabel Llano, Luis Madero, Ana Maria Bueno, Belen Sagastizabal, Daniela Gerovska, Marcos J. Arauzo-Bravo, Itziar Astigarraga, Clara I. Rodriguez
Summary: The study demonstrated the safety and efficacy of reiterative MSCs infusion for pediatric OI patients, with improved bone parameters and quality of life during the treatment period and 2-year follow-up. Mechanistic studies indicated that MSCs therapy triggered a pro-osteogenic paracrine response in patients, especially in those with severe OI.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Rui Alvites, Mariana Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Ana Colette Mauricio
Summary: Mesenchymal Stem/Stromal Cells (MSCs) have high clinical value and have been extensively studied. Their immunomodulatory influence occurs through both direct and paracrine routes, but the mechanisms are not fully understood. This review summarizes the immunoregulatory capacity of MSCs and their secretion products, with a focus on migration, homing, direct cell action, and paracrine activity, and explores related techniques.
Review
Cardiac & Cardiovascular Systems
Michael Nguyen-Truong, Peiman Hematti, Zhijie Wang
Summary: MSCs have been studied for nearly two decades as a therapy for myocardial restoration, with a focus on their paracrine function. Utilizing MSC-derived cell-free approaches for regenerative therapy comes with advantages and disadvantages, and involves mechanisms such as angiogenesis and immunomodulation. Researchers are working towards enhancing these properties to improve therapeutic outcomes, while facing remaining challenges in the field.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thang Quoc Bui, Nguyen Trong Binh, Truc Le-Buu Pham, Trinh Le Van, Nhung Hai Truong, Dang Phu-Hai Nguyen, Thao Thi-Thu Luu, Trang Nguyen-Xuan Pham, Tu Cam Tran, Huyen Thuong-Thi Nguyen, Nhu Thuy-Trinh, Phong Anh Tran
Summary: In this study, the transplantation of human umbilical cord-derived mesenchymal stem cell (MSC) sheets was investigated as a potential treatment for myocardial infarction (MI). The findings showed that MSC sheets with higher cell density had better therapeutic effects on MI mice, with significant improvements in weight gain and ejection fraction recovery. In conclusion, hUC-MSC sheets ameliorated heart MI injury in mice and their efficacy improved with increased cell density.
Review
Cell Biology
Yuxuan Zhong, Xiang Li, Fanglin Wang, Shoushuai Wang, Xiaohong Wang, Xiaohong Tian, Shuling Bai, Di Miao, Jun Fan
Summary: Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. Exosomes play an important role in promoting tissue regeneration and provide new ideas for adipose tissue engineering research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: This study found that pretreatment of mesenchymal stem cells (MSCs) with the Chinese medicine Tongxinluo (TXL) can enhance cardiac repair in acute myocardial infarction (AMI) by transferring miR-146a-5p through exosomes to target the IRAK1/NF-kappa B p65 pathway. This has significant potential for clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Armin Attar, Ahmad Monabati, Mohammad Montaseri, Massoud Vosough, Seyed Ali Hosseini, Javad Kojouri, Alireza Abdi-Ardekani, Peyman Izadpanah, Negar Azarpira, Gholamreza Pouladfar, Mani Ramzi
Summary: This study aims to evaluate the effect of umbilical cord-derived Wharton's jelly MSCs (WJ-MSCs) transplantation on preventing the development of heart failure (HF) after acute myocardial infarction (AMI). It will enroll 390 patients who will be randomly assigned to receive standard care or a single intracoronary infusion of WJ-MSCs. The primary outcome is the assessment of HF development during long-term follow-up (3 years).
Article
Engineering, Environmental
Xianglin Fan, Jie Zhan, Xianmei Pan, Xu Liao, Wenjie Guo, Peier Chen, Hekai Li, Weijing Feng, Yanbin Cai, Minsheng Chen
Summary: Transplantation of stem cells with biomaterials is an effective method for treating degenerative diseases. Synthetic biomaterials, which mimic the native tissue microenvironment, have been extensively used in tissue engineering. However, it is challenging to develop synthetic materials that can mimic the dynamic processes of cell-mediated remodeling.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Genetics & Heredity
Lina Moallemi Rad, Alexey Yumashev, Bashdar Mahmud Hussen, Hazha Hadayat Jamad, Soudeh Ghafouri-Fard, Mohammad Taheri, Samaneh Rostami, Vahid Niazi, Mohammadreza Hajiesmaeili
Summary: Mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-DEs) have therapeutic potential in ocular diseases by promoting eye injury repair and immune modulation.
FRONTIERS IN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang
Summary: The study demonstrates that Hemin-pretreated MSC-derived exosomes are more effective in treating myocardial infarction compared to regular MSC-derived exosomes, with exosomal miR-183-5p playing a key role in inhibiting cardiomyocyte senescence through regulation of the HMGB1/ERK pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Aleksandra Skubis-Sikora, Bartosz Sikora, Weronika Malysiak, Patrycja Wieczorek, Piotr Czekaj
Summary: Melatonin has been evaluated for its safety and biological activity on ADSCs in vitro, and it was found that low-dose melatonin can improve cell viability without negatively affecting osteogenic potential.
Review
Medicine, Research & Experimental
Soudeh Moghadasi, Marischa Elveny, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Siavash Shariatzadeh, Roza Motavalli, Farahnaz Behzad, Faroogh Marofi, Ali Hassanzadeh, Yashwant Pathak, Mostafa Jarahian
Summary: The exosomes derived from MSCs are potential nanocarriers for diagnosis and therapy, transferring functional molecules to target cells to promote tissue repair in various human disorders. Compared to MSCs, MSC-exosomes are more stable and have reduced safety risks, making them a promising cell-free therapeutic strategy in regenerative medicine.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Maria I. Quinones-Vico, Raquel Sanabria de la Torre, Manuel Sanchez-Diaz, Alvaro Sierra-Sanchez, Trinidad Montero-Vilchez, Ana Fernandez-Gonzalez, Salvador Arias-Santiago
Summary: The skin, the largest organ of the human body, has important functions including protection and maintenance. MSCs and their secretome, particularly exosomes, are believed to play a significant role in skin repair and regeneration, indicating the need for further research for clinical translation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Barbara Torrecillas-Baena, Victoria Pulido-Escribano, Gabriel Dorado, Maria Angeles Galvez-Moreno, Marta Camacho-Cardenosa, Antonio Casado-Diaz
Summary: Bone metabolism is regulated by osteoblasts, osteoclasts, osteocytes, and stem cells. Cell therapy based on mesenchymal stem cells (MSC) has been proposed for the treatment of bone diseases, with the regenerative potential of MSC mediated in part by the secretion of extracellular vesicles (EV). MSC-EV modulate inflammation, angiogenesis, cell proliferation, migration, and differentiation, making them a valuable tool in regenerative medicine.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mihai Bogdan Preda, Ana-Maria Rosca, Raluca Tutuianu, Alexandrina Burlacu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Engineering, Biomedical
G. Odent (Grigorescu), M. B. Preda, E. Radu, A. -M. Rosca, R. Tutuianu, D. N. Mitroi, M. Simionescu, A. Burlacu
Article
Cell & Tissue Engineering
Gabriela Odent (Grigorescu), Ana-Maria Rosca, Mihai Bogdan Preda, Raluca Tutuianu, Maya Simionescu, Alexandrina Burlacu
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Cell & Tissue Engineering
Miruna Mihaela Micheu, Ana-Maria Rosca, Oana-Claudia Deleanu
WORLD JOURNAL OF STEM CELLS
(2016)
Article
Chemistry, Multidisciplinary
Raluca Tutuianu, Laura Madalina Popescu, Mihai Bogdan Preda, Ana-Maria Rosca, Roxana Mioara Piticescu, Alexandrina Burlacu
Article
Cell Biology
Ana-Maria Rosca, Daniel Nicolae Mitroi, Valeriu Cismasiu, Rodica Badea, Georgiana Necula-Petrareanu, Mihai Bogdan Preda, Cristina Niculite, Raluca Tutuianu, Stefan Szedlacsek, Alexandrina Burlacu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Cell & Tissue Engineering
Alexandrina Burlacu, Gabriela Grigorescu, Ana-Maria Rosca, Mihai Bogdan Preda, Maya Simionescu
STEM CELLS AND DEVELOPMENT
(2013)
Article
Cell Biology
Raluca Tutuianu, Ana-Maria Rosca, Madalina Georgiana Albu Kaya, Vasile Pruna, Tiberiu Paul Neagu, Ioan Lascar, Maya Simionescu, Irina Titorencu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Review
Cell & Tissue Engineering
Miruna Mihaela Micheu, Ana-Maria Rosca
Summary: This article explores the significance of cardiomyopathies and channelopathies in inherited cardiac conditions, and the potential of using iPSC technology and gene editing to establish disease models and personalized therapies.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Biochemistry & Molecular Biology
Raluca Tutuianu, Ana-Maria Rosca, Daniela Madalina Iacomi, Maya Simionescu, Irina Titorencu
Summary: This study found that MSC-derived exosomes enhance the biological properties of key cell types involved in wound healing, including macrophages, endothelial cells, keratinocytes, and dermal fibroblasts, thus accelerating the process of wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniela-Madalina Iacomi, Ana-Maria Rosca, Raluca Tutuianu, Tiberiu Paul Neagu, Vasile Pruna, Maya Simionescu, Irina Titorencu
Summary: Engineered immortalized ADSC with extended lifespan and maintained beneficial properties could be a valuable tool for wound healing and skin regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Elena-Emilia Tudoroiu, Madalina Georgiana Albu Kaya, Irina Titorencu, Cristina Elena Dinu-Pirvu, Maria Minodora Marin, Ana-Maria Rosca, Lacramioara Popa, Valentina Anuta, Aurora Antoniac, Ciprian Chelaru, Durmu Alpaslan Kaya, Razvan Mihai Prisada, Mihaela Violeta Ghica
Summary: This research aimed to design and characterize new hydrogels and spongious matrices for wound dressings. The compatibility of biopolymers was evaluated through rheological and spectroscopic analyses, and the stability of the matrices was studied in terms of morphology, thermal properties, and biodegradation. The results showed that the dressings had proper swelling ability, stability, and biocompatibility.
MATERIALS & DESIGN
(2023)
Article
Developmental Biology
Raluca Tutuianu, Ana Maria Rosca, Gabriela Florea, Vasile Pruna, Daniela Madalina Iacomi, Luminita Andreea Radulescu, Tiberiu Paul Neagu, Ioan Lascar, Irina Domnica Titorencu
ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
(2019)
Review
Developmental Biology
Ana-Maria Rosca, Raluca Tutuianu, Irina Domnica Titorencu
ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
(2018)