Article
Cell & Tissue Engineering
Chi Zhang, Yinuo Lin, Ke Zhang, Luyang Meng, Xinyang Hu, Jinghai Chen, Wei Zhu, Hong Yu
Summary: The study found that GDF11 can enhance the therapeutic effects of stem cells for ischemic diseases by increasing stem cell viability, mobility, and angiogenic paracrine functions.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Chiara Gardin, Letizia Ferroni, Yasar Kemal Erdogan, Federica Zanotti, Francesco De Francesco, Martina Trentini, Giulia Brunello, Batur Ercan, Barbara Zavan
Summary: Preconditioning of MSCs on nanotubular Ti surfaces induces elevated exosome secretion that stimulates in vitro endothelial and cell activity, potentially improving in vivo angiogenesis and supporting faster scaffold integration.
Article
Neurosciences
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju
Summary: This study investigated the biological effects of EPC-derived MVs on BMECs, showing that EPC-MVs can enhance BMEC viability, proliferation, migration, and tube formation. These results suggest the proangiogenic effect of EPC-derived MVs on BMECs, which holds potential applications in cell-free therapy for brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Fanlu Wang, Yuejun Xiao, Sandesh Neupane, Signe Helle Ptak, Ramona Roemer, Junyu Xiong, Julia Ohmes, Andreas Seekamp, Xavier Frette, Susanne Alban, Sabine Fuchs
Summary: The study characterized fucoidan extracts from different Fucus species and found that they mainly contained high molecular weight fucoidans with no endotoxin contamination. While fucoidans had minimal impact on human outgrowth endothelial cells, they exhibited significant inhibitory effects on human mesenchymal stem cells, leading to decreased expression of key angiogenesis mediators. These findings suggest potential applications of fucoidans in regulating vascularization processes and bone regeneration.
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Kaixuan Yan, Jiaxing Zheng, Mark Andreas Kluth, Lin Li, Christoph Ganss, Benito Yard, Richard Magdeburg, Markus H. H. Frank, Prama Pallavi, Michael Keese
Summary: ABCB5(+) MSCs therapy can restore cellular Ca2+ homeostasis, which may beneficially affect the angiogenic function of endothelial cells under hypoxia in vitro and in vivo.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Min Gong, Min Wang, Jie Xu, Bin Yu, Yi-Gang Wang, Min Liu, Muhammad Ashraf, Meifeng Xu
Summary: The genetically modified MSCs with GATA-4 overexpression released EVs that had an increased capacity for promoting angiogenesis, likely due to the delivery of let-7 miRs targeting THBS1 in endothelial cells.
Article
Cell & Tissue Engineering
Haixia Xu, Chengqiang Wang, Chun Liu, Ziyue Peng, Jianjun Li, Yanglei Jin, Yihan Wang, Jiasong Guo, Lixin Zhu
Summary: The study developed a composite implant to repair steroid-induced osteonecrosis of the femoral head by promoting osteogenesis and angiogenesis while reducing adipogenesis. The cotransplantation of bone marrow mesenchymal stem cells and endothelial progenitor cells in a three-dimensional scaffold showed promising results in treating the condition.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Maria Cristina Vinci, Ermes Carulli, Erica Rurali, Raffaella Rinaldi, Giulia Damiano, Angela Raucci, Giulio Pompilio, Stefano Genovese
Summary: Endothelial progenitor cells (EPCs) have been the subject of extensive research and clinical expectations, but their current status and potential in regenerative medicine remain uncertain. This review explores the past and recent literature on this diverse and intriguing cell population, taking the reader on a chronological journey from their initial discovery to subsequent efforts in understanding their biology and their recent applications in cardiovascular disease and regenerative medicine.
Article
Biochemistry & Molecular Biology
Dayane Mayumi Miyasaki, Alexandra Cristina Senegaglia, Sergio Adriane Bezerra de Moura, Amanda Leitolis, Luiz Guilherme Achcar Capriglione, Leticia Fracaro, Lidiane Maria Boldrini Leite, Paulo Henrique Utumi, Felipe Yukio Ishikawa Fragoso, Fernando Meyer, Alejandro Correa, Paulo Roberto Slud Brofman
Summary: This study evaluated the effects of extracellular vesicles (EVs) from human umbilical cord tissue and human umbilical cord blood on rats with chronic kidney disease. The results demonstrated that EVs have the potential to improve renal function, suggesting their use as a cell-free treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Prakash Gangadaran, Ramya Lakshmi Rajendran, Ji Min Oh, Eun Jung Oh, Chae Moon Hong, Ho Yun Chung, Jaetae Lee, Byeong-Cheol Ahn
Summary: The study found that extracellular vesicles (EVs) derived from stem cells isolated from human adipose tissue contain angiogenic proteins and promote angiogenesis in vitro and in vivo.
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Honorata Kraskiewicz, Piotr Hinc, Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Danuta Witkowska, Isma Liza Mohd Isa, Abhay Pandit, Aleksandra Klimczak
Summary: A potential treatment for chronic wounds using a hydrogel loaded with secretome from adipose tissue mesenchymal stem cells has been proposed. The biocompatibility and pro-angiogenic activity of the hydrogel-released factors were investigated, showing positive effects on skin-origin cell proliferation and endothelial cell angiogenic properties. Additionally, antimicrobial activity was observed in the secretome, indicating its potential use as an advanced wound-healing dressing in combination with the hydrogel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Amrilmaen Badawi, Osfred C. Jefferson, Brooke M. Huuskes, Sharon D. Ricardo, Peter G. Kerr, Chrishan S. Samuel, Padma Murthi
Summary: Circulating bone marrow-derived endothelial progenitor cells (EPCs) play an important role in kidney repair but are reduced in end-stage kidney disease (ESKD) patients. This study found that combining human bone marrow-derived mesenchymal stromal cells (BM-MSCs) and recombinant human relaxin (RLX) can enhance EPC proliferation and function, suggesting a potential treatment for ESKD patients.
Article
Cell & Tissue Engineering
Yang Zhang, Yanqi Zhong, Weifang Liu, Fanghui Zheng, Yin Zhao, Li Zou, Xiaoxia Liu
Summary: The study revealed the importance of PFKFB3-mediated glycolysis in endothelial differentiation and angiogenesis of PMSCs, showing that PMSCs have a strong potential for endothelial differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ana-Maria Vacaru, Madalina Dumitrescu, Andrei Mircea Vacaru, Ioana Madalina Fenyo, Radu Ionita, Anca Violeta Gafencu, Maya Simionescu
Summary: The study aimed to improve the immunomodulatory activity of MSC by inducing FasL overexpression, showing enhanced immunosuppressive properties in FasL-overexpressing MSC. These findings suggest that FasL-overexpressing MSC are promising candidates for therapeutic intervention in autoimmune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Simona-Adriana Manea, Mihaela-Loredana Vlad, Daniela Rebleanu, Alexandra-Gela Lazar, Ioana Madalina Fenyo, Manuela Calin, Maya Simionescu, Adrian Manea
Summary: Excessive production of reactive oxygen species (ROS) plays a key role in atherosclerosis. This study aimed to develop an imaging procedure to monitor ROS overproduction in atherosclerosis. Encapsulation of the ROS BriteTM 700 probe into VCAM-1-targeted liposomes allowed for the quantitative detection of ROS signals in cells and mouse models, providing a novel approach for studying atherosclerosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell & Tissue Engineering
Miruna Mihaela Micheu, Ana-Maria Rosca
Summary: This article explores the significance of cardiomyopathies and channelopathies in inherited cardiac conditions, and the potential of using iPSC technology and gene editing to establish disease models and personalized therapies.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Biochemistry & Molecular Biology
Mihaela Turtoi, Maria Anghelache, Sanda-Maria Bucatariu, Mariana Deleanu, Geanina Voicu, Florentina Safciuc, Ileana Manduteanu, Gheorghe Fundueanu, Maya Simionescu, Manuela Calin
Summary: The newly developed hyaluronic acid-based 3D model is suitable for chemotherapeutic drug testing on hepatocellular carcinoma, showing improved cellular functions and sensitivity compared to 2D cultures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sinziana Popescu, Mihai Bogdan Preda, Catalina Iolanda Marinescu, Maya Simionescu, Alexandrina Burlacu
Summary: The study showed that using a dual-cell approach with ECFC and MSC can enhance the therapeutic effects for infarcted hearts, improving heart function and angiogenic properties. In vitro experiments demonstrated that ECFC can enhance MSC effector properties, while MSC can help organize ECFC into vascular networks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Raluca Tutuianu, Ana-Maria Rosca, Daniela Madalina Iacomi, Maya Simionescu, Irina Titorencu
Summary: This study found that MSC-derived exosomes enhance the biological properties of key cell types involved in wound healing, including macrophages, endothelial cells, keratinocytes, and dermal fibroblasts, thus accelerating the process of wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mihai Bogdan Preda, Carmen Alexandra Neculachi, Ioana Madalina Fenyo, Ana-Maria Vacaru, Mihai Alin Publik, Maya Simionescu, Alexandrina Burlacu
Summary: The study found that transplanted MSC had limited migration capacity and were short-lived, disappearing almost completely within a week of transplantation regardless of the administration route. The transplanted MSC activated hypoxia signaling pathways, followed by apoptosis and subsequent engulfment by macrophages.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Ileana Manduteanu, Dan Simionescu, Agneta Simionescu, Maya Simionescu
Summary: Valve disease, particularly calcific aortic valve disease (CAVD), and diabetes pose a global health burden in aging societies, with diabetic patients showing a greater propensity for cardiovascular disorders. Despite significant advances, there are no pharmacological treatments yet available to reverse or retard aortic valve disease progression in diabetes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Cristina Ana Mocanu, Elena Valeria Fuior, Geanina Voicu, Daniela Rebleanu, Florentina Safciuc, Mariana Deleanu, Ioana Madalina Fenyo, Virginie Escriou, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Summary: The newly developed Psel-lipo/shRAGE lipoplexes reduce the inflammatory processes associated with RAGE signaling and the progression of atherosclerosis in ApoE-deficient mice. Downregulation of RAGE employing these lipoplexes may represent a promising new targeted therapy to block atherosclerosis progression.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Daniela-Madalina Iacomi, Ana-Maria Rosca, Raluca Tutuianu, Tiberiu Paul Neagu, Vasile Pruna, Maya Simionescu, Irina Titorencu
Summary: Engineered immortalized ADSC with extended lifespan and maintained beneficial properties could be a valuable tool for wound healing and skin regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Irina Florina Tudorache, Violeta Georgeta Bivol, Madalina Dumitrescu, Ioana Madalina Fenyo, Maya Simionescu, Anca Violeta Gafencu
Summary: The study found that fullerenol-based nanoparticles carrying apoE3 can limit the progression of atherosclerotic plaques by reducing plasma cholesterol levels and increasing the expression of major proteins involved in lipid metabolism.
PHARMACOLOGICAL REPORTS
(2022)
Article
Materials Science, Multidisciplinary
Elena-Emilia Tudoroiu, Madalina Georgiana Albu Kaya, Irina Titorencu, Cristina Elena Dinu-Pirvu, Maria Minodora Marin, Ana-Maria Rosca, Lacramioara Popa, Valentina Anuta, Aurora Antoniac, Ciprian Chelaru, Durmu Alpaslan Kaya, Razvan Mihai Prisada, Mihaela Violeta Ghica
Summary: This research aimed to design and characterize new hydrogels and spongious matrices for wound dressings. The compatibility of biopolymers was evaluated through rheological and spectroscopic analyses, and the stability of the matrices was studied in terms of morphology, thermal properties, and biodegradation. The results showed that the dressings had proper swelling ability, stability, and biocompatibility.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea
Summary: Accumulating evidence supports the involvement of histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications, with a focus on diabetic kidney disease. Pharmacological inhibition of p300/CBP shows promise in down-regulating the expression of Nox subtypes, inflammation, and fibrosis in the diabetic kidney, potentially reducing the burden of DKD.
Article
Cell Biology
Ana-Mihaela Lupan, Evelyn-Gabriela Rusu, Mihai Bogdan Preda, Catalina Iolanda Marinescu, Cristina Ivan, Alexandrina Burlacu
Summary: This study provides a comprehensive characterization of the aging-associated miRNA profile in murine cardiac fibroblasts, revealing downregulation of miRNAs generated by the Meg3-Mirg locus during aging. The repression of miRNAs from this locus was found to be a general feature of aging in multiple organs, with bioinformatic analysis identifying Integrin Beta-2 as an aged-upregulated gene.