标题
The Transcellular Propagation and Intracellular Trafficking of α-Synuclein
作者
关键词
-
出版物
Cold Spring Harbor Perspectives in Medicine
Volume 7, Issue 9, Pages a024380
出版商
Cold Spring Harbor Laboratory
发表日期
2016-12-06
DOI
10.1101/cshperspect.a024380
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- New insights into cellular α-synuclein homeostasis in health and disease
- (2016) Ulf Dettmer et al. CURRENT OPINION IN NEUROBIOLOGY
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- Protective effect of vagotomy suggests source organ for Parkinson disease
- (2015) Madison T. Gray et al. ANNALS OF NEUROLOGY
- -synuclein assemblies sequester neuronal 3-Na+/K+-ATPase and impair Na+ gradient
- (2015) A. N. Shrivastava et al. EMBO JOURNAL
- Prion degradation pathways: Potential for therapeutic intervention
- (2015) Rob Goold et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The endosomal pathway in Parkinson's disease
- (2015) Rebecca M. Perrett et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
- (2015) Stanley B. Prusiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and -synuclein
- (2015) M. Goedert SCIENCE
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- (2014) Staffan Holmqvist et al. ACTA NEUROPATHOLOGICA
- The Newly Discovered Parkinson’s Disease Associated Finnish Mutation (A53E) Attenuates α-Synuclein Aggregation and Membrane Binding
- (2014) Dhiman Ghosh et al. BIOCHEMISTRY
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour
- (2014) Carlo Breda et al. HUMAN MOLECULAR GENETICS
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein
- (2014) Naoto Sugeno et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
- (2014) Laura A. Volpicelli-Daley et al. MOLECULAR BIOLOGY OF THE CELL
- Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress
- (2014) Nancy N. Fang et al. NATURE CELL BIOLOGY
- Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases
- (2014) He-Jin Lee et al. Nature Reviews Neurology
- Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease
- (2014) Sian E. Davies et al. NEUROBIOLOGY OF DISEASE
- A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy
- (2014) Franziska Richter et al. Neurotherapeutics
- α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
- (2014) Jacqueline Burré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation
- (2014) A. K. Buell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein
- (2014) Eun-Jin Bae et al. Nature Communications
- The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro
- (2013) Dhiman Ghosh et al. BIOCHEMISTRY
- Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
- (2013) Maria Xilouri et al. BRAIN
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells
- (2013) Donna Crabtree et al. JOURNAL OF NEUROCHEMISTRY
- Mapping the Subcellular Distribution of -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis
- (2013) D. Boassa et al. JOURNAL OF NEUROSCIENCE
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
- (2013) David Freeman et al. PLoS One
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
- (2013) Michael A. Nalls et al. JAMA Neurology
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration
- (2012) Y.-D. Kwak et al. JOURNAL OF NEUROSCIENCE
- Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis
- (2012) Chan Hyun Na et al. JOURNAL OF PROTEOME RESEARCH
- Lysosome-dependent pathways as a unifying theme in Parkinson's disease
- (2012) George K. Tofaris MOVEMENT DISORDERS
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation
- (2012) Alexandra Dumitriu et al. PLoS Genetics
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1
- (2011) Hak Joo Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- -Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies
- (2011) Y. Lim et al. JOURNAL OF NEUROSCIENCE
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- Homeostatic Regulation of AMPA Receptor Trafficking and Degradation by Light-Controlled Single-Synaptic Activation
- (2011) Qingming Hou et al. NEURON
- The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein
- (2011) Takafumi Hasegawa et al. PLoS One
- Ubiquitin ligase Nedd4 promotes -synuclein degradation by the endosomal-lysosomal pathway
- (2011) G. K. Tofaris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CNS expression of glucocerebrosidase corrects -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
- (2011) S. P. Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
- (2010) Pablo Garcia-Reitböck et al. BRAIN
- Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
- (2010) Karin M. Danzer et al. FASEB JOURNAL
- The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of β-glucosidase
- (2010) Richie Khanna et al. FEBS Journal
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis
- (2010) James H. Soper et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
- (2010) Francisco Pan-Montojo et al. PLoS One
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Rab11a and HSP90 Regulate Recycling of Extracellular -Synuclein
- (2009) J. Liu et al. JOURNAL OF NEUROSCIENCE
- Parkinson's disease
- (2009) Andrew J Lees et al. LANCET
- The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
- (2009) Camilla Raiborg et al. NATURE
- Physiological functions of the HECT family of ubiquitin ligases
- (2009) Daniela Rotin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH
- (2009) Sebastian McClendon et al. PROTEIN SCIENCE
- Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
- (2009) Valerie Cullen et al. Molecular Brain
- Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†
- (2008) Daniel Sevlever et al. BIOCHEMISTRY
- α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae
- (2008) James H. Soper et al. MOLECULAR BIOLOGY OF THE CELL
- The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
- (2008) Mariese A. Hely et al. MOVEMENT DISORDERS
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
- (2008) Liyan Qiao et al. Molecular Brain
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