Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nutrition & Dietetics
Tsun-Li Cheng, Zi-Yun Lin, Keng-Ying Liao, Wei-Chi Huang, Cian-Fen Jhuo, Pin-Ho Pan, Chun-Jung Chen, Yu-Hsiang Kuan, Wen-Ying Chen
Summary: This study investigated the potential of Magnesium lithospermate B (MLB) in combating muscle atrophy in mice with high-fat diet (HFD)-induced obesity. The results showed that MLB supplementation alleviated metabolic abnormalities and prevented muscle loss caused by obesity, likely through inhibiting muscle degradation pathways. This study also revealed changes in inflammatory markers and signaling pathways associated with muscle atrophy.
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Article
Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Chutimon Termkwancharoen, Wachirawadee Malakul, Amnat Phetrungnapha, Sakara Tunsophon
Summary: This study investigated the effects of naringin on skeletal muscle metabolism in obese rats. The results showed that naringin reduced body weight, improved biochemical parameters, increased antioxidant enzymes, glucose uptake, and protein synthesis, leading to improved muscle mass.
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Endocrinology & Metabolism
Francois Marchildon, Jingyi Chi, Sean O'Connor, Hilary Bediako, Paul Cohen
Summary: This study found that PRDM16 is required for the activation of beige fat in myostatin null mice, but the activation of beige fat is not necessary for the protection from obesity, glucose intolerance, insulin resistance, and hepatic steatosis in these mice. Increasing muscle mass can compensate for the inactivation of beige fat, suggesting that targeting muscle mass may be a therapeutic approach to mitigate the effects of adipose tissue dysfunction in obesity and metabolic syndrome.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Patricia Perez-Matute, Iciar P. Lopez, Maria iniguez, Emma Recio-Fernandez, Raquel Torrens, Sergio Pineiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, Jose A. Oteo, Jose G. Pichel
Summary: This study aims to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. The results showed that young IGF1R-deficient mice were insulin-resistant and had altered circulating levels of IGF1, growth hormone (GH), and IGFBP3. Middle-aged IGF1R-deficient male mice were able to counteract the negative effects induced by aging and high-fat diet (HFD) in adiposity, inflammation, and glucose metabolism, demonstrating a metabolic sexual dimorphism dependent on IGF1R.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaozhong Huang, Qingguo Cao, Cen Chen, Zhenglin Xie, Jinshan Fan
Summary: This study investigates the effects of fermented barley extracts on obesity and inflammatory responses, and suggests that these extracts could be beneficial in improving inflammatory status and gut microflora.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiali Yang, Yunhui Ran, Yonghui Yang, Shuyi Song, Yahong Wu, Yuanming Qi, Yanfeng Gao, Guodong Li
Summary: The study found that 4-HIL can inhibit obesity-related insulin resistance by reducing inflammation and regulating the state of macrophages associated with obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Benjamin Brustolin, Nina Touly, Marine Maillefer, Lola Parisot, Elisa Di Pillo, Marc Derive, Sebastien Gibot
Summary: This study demonstrates that TREM-1 plays a significant role in obesity and its associated complications. In the mouse model of high-fat diet-induced obesity, suppressing TREM-1 reduces weight gain, insulin resistance, and inflammation in white adipose tissue and liver. Therefore, TREM-1 could be a potential therapeutic target for obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chiedozie Kenneth Ugwoke, Erika Cvetko, Nejc Umek
Summary: There is a close relationship between microvascular dysfunction and insulin resistance in obesity, with changes in skeletal muscle microcirculation leading to impaired insulin function and disturbed glucose homeostasis. Various molecular mechanisms and potential pharmacological treatments have been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Juciane de Abreu Ribeiro Pereira, Maria de Fatima Piccolo Barcelos, Eduardo Valerio Villas Boas, Roberta Hilsdorf Piccoli, Janina de Sales Guilarducci, Rafaela Correa Pereira, Jose Rodrigo Pauli, Eric Batista Ferreira, Michel Cardoso de Angelis-Pereira, Dennys Esper Cintra
Summary: This study found that the combination of yacon flour and yogurt with two strains of probiotics had positive effects on metabolic parameters, inflammatory and insulin signaling proteins in diet-induced obese mice. The combination resulted in decreased body weight, fasting glucose, and triacylglycerol levels, as well as reduced fat accumulation. Additionally, it decreased inflammatory markers and improved insulin signaling. These findings suggest that the use of prebiotics and probiotics in food can counteract obesity-associated inflammation and improve insulin resistance in the short term.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Guoqing Zhang, Ran Li, Wu Li, Sijia Yang, Qing Sun, Hongping Yin, Cui Wang, Biyu Hou, Huanhuan Wang, Liping Yu, Rucheng Chen, Liyun Shi, Kezhong Zhang, Chong Wee Liew, Guifen Qiang, Qinghua Sun, Cuiqing Liu
Summary: TLR3 plays a crucial role in obesity and metabolic disorders, as demonstrated by the protective effects of TLR3 deficiency against high-fat diet-induced obesity, glucose intolerance, insulin resistance, and lipid accumulation. These findings provide new mechanistic links between inflammation and obesity-related metabolic abnormalities in lipid/glucose metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Biology
Anna F. Sheptulina, Karina Yu Antyukh, Anton R. Kiselev, Natalia P. Mitkovskaya, Oxana M. Drapkina
Summary: Increasing evidence suggests that skeletal muscles may play a role in the pathogenesis of obesity and associated conditions. Skeletal muscles, along with adipose tissue, are recognized as endocrine organs, producing biologically active substances. The amount and location of adipose tissue in relation to skeletal muscles is important for metabolic health.