Interleukin-34 sustains inflammatory pathways in the gut

IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells

(2014) Laurence Preisser et al.   HEPATOLOGY

IL-34 Is Associated with Obesity, Chronic Inflammation, and Insulin Resistance

(2014) Eun-Ju Chang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Baseline serum interleukin-34 levels independently predict radiographic progression in patients with rheumatoid arthritis

(2014) Sung Hae Chang et al.   RHEUMATOLOGY INTERNATIONAL

Increased Serum Interleukin-34 in Patients with Coronary Artery Disease

(2013) Zhenglong Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

IL-34 Induces the Differentiation of Human Monocytes into Immunosuppressive Macrophages. Antagonistic Effects of GM-CSF and IFNγ

(2013) Etienne D. Foucher et al.   PLoS One

IL-34 is overexpressed in the inflamed salivary glands of patients with Sjogren's syndrome and is associated with the local expansion of pro-inflammatory CD14brightCD16+ monocytes

(2013) F. Ciccia et al.   RHEUMATOLOGY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Identification of IL-34 in teleost fish: Differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor

(2012) Tiehui Wang et al.   MOLECULAR IMMUNOLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R

(2012) Xiaolei Ma et al.   STRUCTURE

Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis

(2012) Seung-Jun Hwang et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients

(2011) M Chemel et al.   ANNALS OF THE RHEUMATIC DISEASES

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis

(2011) William J. Sandborn et al.   GASTROENTEROLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

(2010) T Chihara et al.   CELL DEATH AND DIFFERENTIATION

MAP kinases in inflammatory bowel disease

(2010) Mehmet Coskun et al.   CLINICA CHIMICA ACTA

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis

(2010) Marc Baud'Huin et al.   JOURNAL OF PATHOLOGY

Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts

(2010) Hiroyuki Eda et al.   RHEUMATOLOGY INTERNATIONAL

NKT cells in mucosal immunity

(2009) S Middendorp et al.   Mucosal Immunology

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE