Pound the alarm: danger signals in rheumatic diseases

Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-κB

(2014) Steven O'Reilly et al.   IMMUNOLOGY

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

(2014) S. M. Sacre et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

A Citrullinated Fibrinogen-Specific T Cell Line Enhances Autoimmune Arthritis in a Mouse Model of Rheumatoid Arthritis

(2013) K. N. Cordova et al.   JOURNAL OF IMMUNOLOGY

Citrullination enhances the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts

(2012) Olga Sanchez-Pernaute et al.   ANNALS OF THE RHEUMATIC DISEASES

Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors

(2012) Marzena Ciechomska et al.   ANNALS OF THE RHEUMATIC DISEASES

The inhibition of hyaluronan degradation reduced pro-inflammatory cytokines in mouse synovial fibroblasts subjected to collagen-induced arthritis

(2012) Giuseppe M. Campo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Endogenous Control of Immunity against Infection: Tenascin-C Regulates TLR4-Mediated Inflammation via MicroRNA-155

(2012) Anna M. Piccinini et al.   Cell Reports

Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis

(2011) M. Connolly et al.   ANNALS OF THE RHEUMATIC DISEASES

A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

(2011) J. C. A. Broen et al.   ARTHRITIS AND RHEUMATISM

 9 1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation

(2011) M. Kanayama et al.   JOURNAL OF IMMUNOLOGY

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(2011) Hanna Schierbeck et al.   MOLECULAR MEDICINE

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors

(2010) Sandra Sacre et al.   ARTHRITIS AND RHEUMATISM

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Transcriptional Regulation of the Endogenous Danger Signal Tenascin-C: A Novel Autocrine Loop in Inflammation

(2010) Fui G. Goh et al.   JOURNAL OF IMMUNOLOGY

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint

(2009) M. Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-α in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice

(2009) Young Ok Jung et al.   IMMUNOLOGY LETTERS

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

IL-10 Is Critically Involved in Mycobacterial HSP70 Induced Suppression of Proteoglycan-Induced Arthritis

(2009) Lotte Wieten et al.   PLoS One

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

(2008) Takashi Hamada et al.   ARTHRITIS AND RHEUMATISM

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity

(2008) Ayumi Yoshizaki et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis

(2008) Leo A. B. Joosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling

(2008) Rille Pullerits et al.   ARTHRITIS RESEARCH & THERAPY

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

(2008) Xiaoyan Zhao et al.   ARTHRITIS RESEARCH & THERAPY