A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts

Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis

(2015) Tomohiro Shimizu et al.   BONE

Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis

(2015) Yusuke Kameda et al.   BONE

OSCAR Is a Receptor for Surfactant Protein D That Activates TNF-α Release from Human CCR2+Inflammatory Monocytes

(2015) Alexander D. Barrow et al.   JOURNAL OF IMMUNOLOGY

Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12

(2015) Masayuki Kamimura et al.   PLoS One

Immune complexes regulate bone metabolism through FcRγ signalling

(2015) Takako Negishi-Koga et al.   Nature Communications

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss

(2015) Tania N. Crotti et al.   Journal of Immunology Research

Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk

(2014) Ndiemé Ndongo-Thiam et al.   ANNALS OF THE RHEUMATIC DISEASES

Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis

(2014) Wei Zou et al.   JOURNAL OF CELL BIOLOGY

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

(2014) Susan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibitory Immunoglobulin-Like Receptors LILRB and PIR-B Negatively Regulate Osteoclast Development

(2014) Y. Mori et al.   JOURNAL OF IMMUNOLOGY

Crosstalk among IL-23 and DNAX Activating Protein of 12 kDa–Dependent Pathways Promotes Osteoclastogenesis

(2014) Hyun-Seock Shin et al.   JOURNAL OF IMMUNOLOGY

Cells of the Immune System Orchestrate Changes in Bone Cell Function

(2013) Sarah E. Wythe et al.   CALCIFIED TISSUE INTERNATIONAL

Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

(2013) Yusuke Kameda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fcγ receptors on myeloid precursor cells

(2012) Lilyanne C Grevers et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation

(2012) M.S.F. Zawawi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice

(2012) Yoshiharu Hiruma et al.   BONE

TLT-1s, Alternative Transcripts of Triggering Receptor Expressed on Myeloid Cell-like Transcript-1 (TLT-1), Inhibits the Triggering Receptor Expressed on Myeloid Cell-2 (TREM-2)-mediated Signaling Pathway during Osteoclastogenesis

(2012) Soo-Hyun Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAX-activating Protein of 12 kDa (DAP12)

(2012) Norihiro Ishida-Kitagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of sialic acid as a modulator of the anti-inflammatory activity of IgG

(2012) Sybille Böhm et al.   Seminars in Immunopathology

The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints

(2012) Tania N Crotti et al.   ARTHRITIS RESEARCH & THERAPY

Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice

(2011) Lindsay M. MacLellan et al.   ARTHRITIS AND RHEUMATISM

Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation

(2011) Yoshiharu Hiruma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Osteoclast-Associated Receptor (OSCAR) Is a Novel Receptor Regulated by Oxidized Low-Density Lipoprotein in Human Endothelial Cells

(2011) Claudia Goettsch et al.   ENDOCRINOLOGY

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)

(2011) Ya-Hui Chiu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

(2011) David J Mellis et al.   JOURNAL OF ENDOCRINOLOGY

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

(2010) Hans U. Scherer et al.   ARTHRITIS AND RHEUMATISM

Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation

(2010) Mikihito Hayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts

(2010) W. Zou et al.   JOURNAL OF CELL SCIENCE

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis

(2010) Barbara Joyce-Shaikh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor

(2009) Aleksandra A. Watson et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Osteoclast heterogeneity:

(2009) Vincent Everts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells

(2009) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

(2009) Takako Negishi-Koga et al.   IMMUNOLOGICAL REVIEWS

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

IL-10 Suppresses Calcium-Mediated Costimulation of Receptor Activator NF- B Signaling during Human Osteoclast Differentiation by Inhibiting TREM-2 Expression

(2009) K.-H. Park-Min et al.   JOURNAL OF IMMUNOLOGY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12

(2009) M. Inui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis

(2008) Sonja Herman et al.   ARTHRITIS AND RHEUMATISM

Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future

(2008) Marc Daëron et al.   IMMUNOLOGICAL REVIEWS

DAP10- and DAP12-associated receptors in innate immunity

(2008) Lewis L. Lanier   IMMUNOLOGICAL REVIEWS

Upstream Stimulatory Factors Regulate OSCAR Gene Expression in RANKL-Mediated Osteoclast Differentiation

(2008) Jung Ha Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk

(2008) Wei Zou et al.   MOLECULAR CELL