Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy

Multifunctional pH-Sensitive Amino Lipids for siRNA Delivery

(2015) Maneesh Gujrati et al.   BIOCONJUGATE CHEMISTRY

Dual-targeting and pH/redox-responsive multi-layered nanocomplexes for smart co-delivery of doxorubicin and siRNA

(2015) Lu Han et al.   BIOMATERIALS

Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis

(2015) F. Pettersson et al.   CANCER RESEARCH

Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer

(2015) Jenny G. Parvani et al.   CANCER RESEARCH

Differential Requirements for eIF4E Dose in Normal Development and Cancer

(2015) Morgan L. Truitt et al.   CELL

The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma

(2015) Yao Zhan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

When Will Resistance Be Futile?

(2014) K. L. B. Borden   CANCER RESEARCH

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E

(2014) S. Assouline et al.   HAEMATOLOGICA

Dual Targeting of Integrin  v 3 and Matrix Metalloproteinase-2 for Optical Imaging of Tumors and Chemotherapeutic Delivery

(2014) J. L. Crisp et al.   MOLECULAR CANCER THERAPEUTICS

Multifunctional Cationic Lipid-Based Nanoparticles Facilitate Endosomal Escape and Reduction-Triggered Cytosolic siRNA Release

(2014) Maneesh Gujrati et al.   MOLECULAR PHARMACEUTICS

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

(2014) N Robichaud et al.   ONCOGENE

Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment

(2013) Tuomas Heikkinen et al.   BREAST CANCER RESEARCH AND TREATMENT

Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery

(2013) Anthony S. Malamas et al.   JOURNAL OF CONTROLLED RELEASE

A Solution to the PEG Dilemma: Efficient Bioconjugation of Large Gold Nanoparticles for Biodiagnostic Applications using Mixed Layers

(2012) Tianqing Liu et al.   LANGMUIR

Integrin Targeted MR Imaging

(2012) Mingqian Tan et al.   Theranostics

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer

(2011) F. Pettersson et al.   CLINICAL CANCER RESEARCH

A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer

(2011) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity

(2011) Erez Koren et al.   JOURNAL OF CONTROLLED RELEASE

Targeting the eIF4F translation initiation complex for cancer therapy

(2010) Bruce W. Konicek et al.   CELL CYCLE

Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer

(2010) A. C. Hsieh et al.   CLINICAL CANCER RESEARCH

Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting

(2010) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells

(2010) Fei-fei Zhou et al.   MEDICAL ONCOLOGY

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

Targeted Systemic Delivery of a Therapeutic siRNA with a Multifunctional Carrier Controls Tumor Proliferation in Mice

(2009) Xu-Li Wang et al.   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Eukaryotic initiation factor 4E overexpression in triple-negative breast cancer predicts a worse outcome

(2009) Anthony Flowers et al.   SURGERY

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling

(2008) A. Soni et al.   MOLECULAR CANCER THERAPEUTICS

A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery

(2007) Xu-Li Wang et al.   BIOMATERIALS