Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children
出版年份 2015 全文链接
标题
Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children
作者
关键词
-
出版物
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 98, Issue 3, Pages 298-308
出版商
Wiley
发表日期
2015-06-13
DOI
10.1002/cpt.169
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- (2015) Kayode Ogungbenro et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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- (2015) Trevor N. Johnson et al. CLINICAL PHARMACOKINETICS
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- (2014) Feras Khalil et al. AAPS Journal
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- (2014) Diane R. Mould et al. AAPS Journal
- Bridging the gap: a review of dose investigations in paediatric investigation plans
- (2014) Lisa V. Hampson et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children
- (2014) Nicole R. Zane et al. CLINICAL PHARMACOKINETICS
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- (2014) Iftekhar Mahmood CLINICAL PHARMACOKINETICS
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- (2014) D Gonzalez et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- A physiologically based pharmacokinetic model for Valproic acid in adults and children
- (2014) Kayode Ogungbenro et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate
- (2014) Kayode Ogungbenro et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate
- (2014) Kayode Ogungbenro et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
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- (2014) Christian Diestelhorst et al. PEDIATRIC HEMATOLOGY AND ONCOLOGY
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- (2014) Kayode Ogungbenro et al. PHARMACEUTICAL RESEARCH
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- (2013) A. R. Maharaj et al. AAPS Journal
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- (2013) Nikolaos Tsamandouras et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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- (2013) J M Gallo CLINICAL PHARMACOLOGY & THERAPEUTICS
- Therapeutic Drug Monitoring as a Component of Personalized Medicine: Applications in Pediatric Drug Development
- (2013) J D Momper et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Asthma across the ages: Knowledge gaps in childhood asthma
- (2013) Stanley J. Szefler et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Population Pharmacokinetics of Sirolimus in Pediatric Patients With Neurofibromatosis Type 1
- (2013) Jeffrey R. Scott et al. THERAPEUTIC DRUG MONITORING
- Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice
- (2012) Joseph A. Grillo et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Dosing Rationale for Fixed-Dose Combinations in Children: Shooting From the Hip?
- (2012) M Cella et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials
- (2012) R Leong et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Sample size calculation for the proportional hazards cure model
- (2012) Songfeng Wang et al. STATISTICS IN MEDICINE
- Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science
- (2011) Malcolm Rowland et al. Annual Review of Pharmacology and Toxicology
- Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children
- (2011) Gisela Kersting et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
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- (2011) Neil Parrott et al. CLINICAL PHARMACOKINETICS
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- (2011) Brian J. Anderson et al. PEDIATRIC ANESTHESIA
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- (2011) J. Dunne et al. PEDIATRICS
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- (2010) D R Abernethy et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review
- (2010) P Zhao et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- A Model-Based Approach to Dose Selection in Early Pediatric Development
- (2010) M Cella et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Advances in paediatric pharmacokinetics
- (2010) Catherijne AJ Knibbe et al. Expert Opinion on Drug Metabolism & Toxicology
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- (2010) Rajanikanth Madabushi et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2010) Trevor N. Johnson et al. PEDIATRIC ANESTHESIA
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- (2009) Efthymios Manolis et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- What is the right dose for children?
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- Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics
- (2007) B.J. Anderson et al. Annual Review of Pharmacology and Toxicology
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