The In Silico Child: Using Simulation to Guide Pediatric Drug Development and Manage Pediatric Pharmacotherapy

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Concepts and Challenges in Quantitative Pharmacology and Model-Based Drug Development

(2008) Liping Zhang et al.   AAPS Journal

Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists

(2008) M. Rybak et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Population Pharmacokinetics of Fluconazole in Young Infants

(2008) K. C. Wade et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy

(2008) Jeffrey S Barrett et al.   BMC Medical Informatics and Decision Making

Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods

(2008) Kenneth H. Grime et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pediatric Antihypertensive Trial Failures

(2008) Daniel K. Benjamin et al.   HYPERTENSION

Communicating With the FDA: The “Third Rail” of a New Model for Drug Development

(2008) Donald R. Stanski et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Globalization of Quantitative Pharmacology: First International Symposium of Quantitative Pharmacology in Drug Development and Regulation

(2008) Jeffrey S. Barrett et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Leveraging Prior Quantitative Knowledge to Guide Drug Development Decisions and Regulatory Science Recommendations: Impact of FDA Pharmacometrics During 2004-2006

(2008) Yaning Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacometrics: A Multidisciplinary Field to Facilitate Critical Thinking in Drug Development and Translational Research Settings

(2008) Jeffrey S. Barrett et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Human renal function maturation: a quantitative description using weight and postmenstrual age

(2008) Malin M. Rhodin et al.   PEDIATRIC NEPHROLOGY

Off-label drug use among hospitalised children: identifying areas with the highest need for research

(2008) Linda Hsien et al.   PHARMACY WORLD & SCIENCE

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure

(2007) Stefanie Albers et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Population Pharmacokinetic Investigation of Actinomycin-D in Children and Young Adults

(2007) Joh T. Mondick et al.   JOURNAL OF CLINICAL PHARMACOLOGY