ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

(2015) Prashant Mishra et al.   Cell Metabolism

CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation

(2015) H. Peng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

(2015) Anne-Laure Poher et al.   Frontiers in Physiology

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Myokines in insulin resistance and type 2 diabetes

(2014) Kristin Eckardt et al.   DIABETOLOGIA

Serum levels of the myokine irisin in relation to metabolic and renal function

(2014) Thomas Ebert et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Insulin resistance in chronic kidney disease: a step closer to effective evaluation and treatment

(2014) Ian H. de Boer et al.   KIDNEY INTERNATIONAL

Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age

(2013) Darren T. Hwee et al.   AGING CELL

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

(2013) Seung-Hwan Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Relationship between circulating irisin, renal function and body composition in type 2 diabetes

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin, the metabolic syndrome and follistatin in humans

(2013) Pontus A. Boström et al.   Nature Reviews Endocrinology

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

(2013) Harald Staiger et al.   PLoS One

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

(2013) Aditi U. Gurkar et al.   Nature Communications

“Browning” of adipose tissue – regulation and therapeutic perspectives

(2013) Alessandro Peschechera et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Increasing muscle mass to improve metabolism

(2013) Alexandra C. McPherron et al.   Adipocyte

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Myostatin Inhibition Prevents Diabetes and Hyperphagia in a Mouse Model of Lipodystrophy

(2012) T. Guo et al.   DIABETES

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment

(2011) Darren T. Hwee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Itsin VivoKnockdown Prevents Progression of Diabetic Nephropathy

(2011) Jianyin Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes

(2010) Kwang-Hoon Chun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of the ROCK1 Branch of the Transforming Growth Factor-β Pathway Contributes to RAGE-Dependent Acceleration of Atherosclerosis in Diabetic ApoE-Null Mice

(2010) De-xiu Bu et al.   CIRCULATION RESEARCH

Brown adipose tissue in humans

(2010) Kirsi A Virtanen et al.   CURRENT OPINION IN LIPIDOLOGY

A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity

(2010) Rikke Krogh-Madsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Minireview: β-Cell Replacement Therapy for Diabetes in the 21st Century: Manipulation of Cell Fate by Directed Differentiation

(2010) Vijay Yechoor et al.   MOLECULAR ENDOCRINOLOGY

Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage

(2008) R. Arita et al.   DIABETES

Metabolic Responses to Reduced Daily Steps in Healthy Nonexercising Men

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION