4.7 Article

ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

期刊

SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -

出版社

NATURE PORTFOLIO
DOI: 10.1038/srep23250

关键词

-

资金

  1. National Natural Science Foundation of China [81070171]

向作者/读者索取更多资源

ABO blood group system, a well-known genetic risk factor, has clinically been demonstrated to be linked with thrombotic vascular diseases. However, the relationship between ABO blood group and coronary artery disease (CAD) is still controversial. We here performed an updated meta-analysis of the related studies and tried to elucidate the potential role of ABO blood group as a risk factor for CAD. All detectable case-control and cohort studies comparing the risk of CAD in different ABO blood groups were collected for this analysis through searching PubMed, Embase, and the Cochrane Library. Ultimately, 17 studies covering 225,810 participants were included. The combined results showed that the risk of CAD was significantly higher in blood group A (OR = 1.14, 95% CI = 1.03 to 1.26, p = 0.01) and lower in blood group O (OR = 0.85, 95% CI = 0.78 to 0.94, p = 0.0008). Even when studies merely about myocardial infarction (MI) were removed, the risk of CAD was still significantly higher in blood group A (OR = 1.05, 95% CI = 1.00 to 1.10, p = 0.03) and lower in blood group O (OR = 0.89, 95% CI = 0.85 to 0.93, p < 0.00001). This updated systematic review and meta-analysis indicated that both blood group A and non-O were the risk factors of CAD.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Pharmacology & Pharmacy

Using herbal medicine to target the microbiota-metabolism-immunity axis as possible therapy for cardiovascular disease

Wang Anlu, Cai Dongcheng, Zhang He, Li Qiuyi, Zhang Yan, Qiu Yu, Xu Hao, Chen Keji

PHARMACOLOGICAL RESEARCH (2019)

Article Cardiac & Cardiovascular Systems

Meta-Analysis Comparing Metoprolol and Carvedilol on Mortality Benefits in Patients With Acute Myocardial Infarction

Jingen Li, Zhuo Chen, Xiang Gao, He Zhang, Wenjing Xiong, Jianging Ju, Hao Xu

AMERICAN JOURNAL OF CARDIOLOGY (2017)

暂无数据