Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways

Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

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Systematic review and meta-analysis of randomized controlled trials comparing compound danshen dripping pills and isosorbide dinitrate in treating angina pectoris

(2015) Yannan Yao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells

(2015) Xuelin Zhou et al.   JOURNAL OF NATURAL PRODUCTS

Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells

(2015) Ching-Fen Wu et al.   JOURNAL OF NATURAL PRODUCTS

Metabolic profile of miltirone in rats by high performance liquid chromatography/quadrupole time-of-flight mass spectrometry

(2015) Long Guo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

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Antitumor Activity of Gemcitabine Can Be Potentiated in Pancreatic Cancer through Modulation of TLR4/NF-κB signaling by 6-Shogaol

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The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

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Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation

(2014) Victor Romanov et al.   ARCHIVES OF TOXICOLOGY

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

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Ca2+-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation

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A simple and sensitive LC–MS/MS method for determination of miltirone in rat plasma and its application to pharmacokinetic studies

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Endoplasmic reticulum stress triggers ROS signalling, changes the redox state, and regulates the antioxidant defence of Arabidopsis thaliana

(2014) Rengin Ozgur et al.   JOURNAL OF EXPERIMENTAL BOTANY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

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Millepachine, a novel chalcone, induces G 2 /M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo

(2013) Wenshuang Wu et al.   CARCINOGENESIS

6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α

(2013) Qun Liu et al.   Molecular Cancer

Role of 53BP1 oligomerization in regulating double-strand break repair

(2013) F. Lottersberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Mcl-1 through inhibition of translation contributes to benzyl isothiocyanate-induced cell cycle arrest and apoptosis in human leukemia cells

(2013) T Zhou et al.   Cell Death & Disease

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

(2012) Andrea R Tentner et al.   Molecular Systems Biology

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

BRCT Domain Interactions with Phospho-Histone H2A Target Crb2 to Chromatin at Double-Strand Breaks and Maintain the DNA Damage Checkpoint

(2010) S. Sofueva et al.   MOLECULAR AND CELLULAR BIOLOGY

Therapeutic strategies by modulating oxygen stress in cancer and inflammation

(2009) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: Nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin

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