Article
Gastroenterology & Hepatology
Sathisha Upparahalli Venkateshaiah, Chandra Sekhar Yadavalli, Hemanth Kumar Kandikattu, Sandeep Kumar, Lokanatha Oruganti, Anil Mishra
Summary: This study aims to investigate the molecules involved in the development of Barrett's esophagus in patients with human eosinophilic esophagitis (EoE). The findings suggest that IL-9 plays an important role in the initiation and progression of BE characteristics in patients with chronic EoE.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Article
Gastroenterology & Hepatology
Emily L. Black, Emma Ococks, Ginny Devonshire, Alvin Wei Tian Ng, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Adam Freeman, Hannah Coles, Rebecca C. Fitzgerald
Summary: The controversy of whether gastric metaplasia should be considered as Barrett's esophagus is explored in this study. Through clinical and genomic analysis, the researchers found that the malignant potential of gastric metaplasia is lower than intestinal metaplasia. Therefore, the inclusion of gastric metaplasia in the surveillance of Barrett's esophagus is questionable.
Review
Medicine, General & Internal
Maja Mejza, Ewa Malecka-Wojciesko
Summary: Barrett's esophagus is a precancerous condition of the esophagus, characterized by a salmon-colored lining and the presence of columnar epithelium with goblet cells. It is associated with esophageal adenocarcinoma, a tumor with poor survival rates and increasing incidence. The diagnosis and management of Barrett's esophagus remain a topic of ongoing debate. This article provides an overview of current recommendations and new discoveries in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Vani Konda, Rhonda F. Souza, Kerry B. Dunbar, Jason C. Mills, Daniel S. Kim, Robert D. Odze, Stuart J. Spechler
Summary: This study aimed to characterize the early endoscopic and histologic features of radiofrequency ablation (RFA) wound healing in patients with Barrett's esophagus (BE). The results showed that squamous re-epithelialization of RFA wounds not only progressed through squamous cells extending from the proximal wound edge, but also through islands of squamous epithelium sprouting throughout the ablated segment. Additionally, subepithelial glandular structures associated with the squamous islands were found to increase post-RFA. Furthermore, subsquamous intestinal metaplasia (SSIM) was detected in biopsies of patients during the healing process. This study provides insights into the mechanisms of esophageal metaplasia and the healing of RFA wounds.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicholas J. Shaheen, Gary W. Falk, Prasad G. Iyer, Rhonda F. Souza, Rena H. Yadlapati, Bryan G. Sauer, Sachin Wani
Summary: Barrett's esophagus is a common condition associated with chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The revised guidelines propose recommendations for the definition, diagnosis, screening, surveillance, and treatment of Barrett's esophagus, including important changes such as expanding acceptable screening methods and volume criteria for treatment centers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Chengjiao Yao, Yilin Li, Lihong Luo, Qin Xiong, Xiaowu Zhong, Fengjiao Xie, Peimin Feng
Summary: The study identified differentially expressed miRNAs (DEMs) and genes (DEGs) between EAC and BE tissue samples, performed pathway and functional enrichment analysis, and identified enriched functions and pathways. Some hub genes, such as GART and TNFSF11, as well as highly connected miRNAs like hsa-miR-143 and hsa-miR-133b were determined. This research provides insights into the development mechanism of BE and EAC.
Article
Gastroenterology & Hepatology
Qiuyang Zhang, Ajay Bansal, Kerry B. Dunbar, Yan Chang, Jianning Zhang, Uthra Balaji, Jinghua Gu, Xi Zhang, Eitan Podgaetz, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza
Summary: Reflux-induced epithelial-mesenchymal plasticity (EMP) may play a role in the development of subsquamous intestinal metaplasia (SSIM) in Barrett's esophagus (BE), potentially allowing Barrett's cells to migrate underneath squamous epithelium. This phenomenon could contribute to the formation of Barrett's cancers that escape detection by endoscopic surveillance and recurrences of Barrett's metaplasia following endoscopic eradication therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Surgery
Colin P. Dunn, Justin C. Henning, Jason A. Sterris, Paul Won, Caitlin Houghton, Nikolai A. Bildzukewicz, John C. Lipham
Summary: This retrospective study evaluated the effectiveness of MSA for Barrett's esophagus patients, showing significant reduction in Barrett's length and prevention of progression to dysplasia or neoplasia. The results remained consistent after 2 years of follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Joel H. Rubenstein, Li Jiang, Jacob E. Kurlander, Joan Chen, Valbona Metko, Maryam Khodadost, Kimberly Nofz, Trivellore Raghunathan
Summary: The study found an association between incomplete response of GERD symptoms to PPI and psychological distress, but it is not a good predictor for endoscopic pathology. Patients with high psychological distress are less likely to have esophageal pathology such as erosive esophagitis or Barrett's esophagus.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Genetics & Heredity
Nandan P. Deshpande, Stephen M. Riordan, Claire J. Gorman, Shaun Nielsen, Tonia L. Russell, Carolina Correa-Ospina, Bentotage S. M. Fernando, Shafagh A. Waters, Natalia Castano-Rodriguez, Si Ming Man, Nicodemus Tedla, Marc R. Wilkins, Nadeem O. Kaakoush
Summary: This study comprehensively assessed the esophageal microenvironment in patients with gastro-esophageal reflux disease and metaplasia, identifying bacterial strain-specific signatures with high relevance to disease progression.
Article
Medicine, General & Internal
Adam G. Berman, W. Keith Tan, Maria O'Donovan, Florian Markowetz, Rebecca C. Fitzgerald
Summary: This study aimed to assess the diagnostic value of Cytosponge-TFF3 test in distinguishing clinically relevant Barrett's oesophagus from focal intestinal metaplasia pathologies, and to automate TFF3 counting using machine learning. The results showed that TFF3 counting could differentiate these two pathologies with high precision and accuracy. It could help minimize overdiagnosis of focal intestinal metaplasia pathologies with low cancer-associated risk.
Article
Gastroenterology & Hepatology
Cary C. Cotton, Nicholas J. Shaheen, Aaron P. Thrift
Summary: Endoscopic surveillance after successful ablation of baseline high-grade dysplasia or intramucosal cancer is much more effective than surveillance after successful treatment of baseline low-grade dysplasia in preventing invasive adenocarcinoma.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Camille Peneau, Sandrine Imbeaud, Tiziana La Bella, Theo Z. Hirsch, Stefano Caruso, Julien Calderaro, Valerie Paradis, Jean-Frederic Blanc, Eric Letouze, Jean-Charles Nault, Giuliana Amaddeo, Jessica Zucman-Rossi
Summary: This study aimed to characterize HBV integrations in liver tissues of HCC patients and revealed new mechanisms of HBV-associated oncogenesis. HBV integrations have direct oncogenic consequences, posing a challenge for the monitoring of HBV-infected patients.
Article
Oncology
Maria Grazia Tibiletti, Ileana Carnevali, Valentina Calo, Giulia Cini, Emanuela Lucci Cordisco, Andrea Remo, Emanuele Urso, Cristina Oliani, Guglielmina Nadia Ranzani
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Oncology
Cong Trung Nguyen, Stefano Caruso, Pascale Maille, Aurelie Beaufrere, Jeremy Augustin, Loetitia Favre, Anais Pujals, Camille Boulagnon-Rombi, Rami Rhaiem, Giuliana Amaddeo, Luca di Tommaso, Alain Luciani, Helene Regnault, Raffaele Brustia, Olivier Scatton, Frederic Charlotte, Isabelle Brocheriou, Daniele Sommacale, Patrick Soussan, Vincent Leroy, Alexis Laurent, Van Ky Le, Van To Ta, Hong Son Trinh, Thi Lan Tran, David Gentien, Audrey Rapinat, Jean Charles Nault, Manon Allaire, Sebastien Mule, Jessica Zucman-Rossi, Jean-Michel Pawlotsky, Christophe Tournigand, Fouad Lafdil, Valerie Paradis, Julien Calderaro
Summary: This study identified two immune subtypes of combined hepatocellular-cholangiocarcinoma (cHCC-CCA): an immune-high subtype characterized by higher densities of immune cells and activation of gene signatures related to immune response and immunotherapy in hepatocellular carcinoma (HCC), and an immune-low subtype. The immune-high subtype was associated with improved overall survival. These findings suggest that a subset of cHCC-CCA patients may benefit from immunomodulating therapeutic approaches.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Pasquale Pisapia, Francesco Pepe, Anna Baggi, Massimo Barberis, Antonio Galvano, Valerio Gristina, Fabrizio Mastrilli, Silvia Novello, Fabio Pagni, Silvia Pasini, Giuseppe Perrone, Daniela Righi, Antonio Russo, Giancarlo Troncone, Umberto Malapelle
Summary: The KWAY project aimed to investigate the economic sustainability of adopting upfront NGS technologies in analyzing molecular alterations in NSCLC patients. Different testing strategies were evaluated in Italian referral centers, with results verified through a sensitivity analysis to ensure consistency and cost-saving benefits of NGS adoption.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Aurelie Beaufrere, Stefano Caruso, Julien Calderaro, Nicolas Pote, Jean-Charles Bijot, Gabielle Couchy, Francois Cauchy, Valerie Vilgrain, Jessica Zucman-Rossi, Valerie Paradis
Summary: With the use of transcriptomic signature, we identified a 6-gene expression signature that is associated with microvascular invasion in hepatocellular carcinoma (HCC). This signature can be applied to routine tumor biopsies and is also associated with overall survival.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Daniele Fanale, Lidia Rita Corsini, Chiara Brando, Alessandra Dimino, Clarissa Filorizzo, Luigi Magrin, Roberta Sciacchitano, Alessia Fiorino, Tancredi Didier Bazan Russo, Valentina Calo, Juan Lucio Iovanna, Edoardo Francini, Antonio Russo, Viviana Bazan
Summary: Lynch syndrome is a genetic condition associated with an increased predisposition to colorectal cancer and other tumors. The most efficient strategy to identify patients with this syndrome is still unclear. A study found that analyzing tissue microsatellite instability according to the revised Bethesda guidelines is the best selection approach, but using different selection methods as complementary strategies helps reduce underdiagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
W. Bruno, B. Dalmasso, M. Barile, V Andreotti, L. Elefanti, M. Colombino, I Vanni, E. Allavena, F. Barbero, E. Passoni, B. Merelli, S. Pellegrini, F. Morgese, R. Danesi, V Calo, V Bazan, A. D'Elia, C. Molica, F. Gensini, E. Sala, V Uliana, P. F. Soma, M. Genuardi, A. Ballestrero, F. Spagnolo, E. Tanda, P. Queirolo, M. Mandala, I Stanganelli, G. Palmieri, C. Menin, L. Pastorino, P. Ghiorzo
Summary: The incidence of cutaneous melanoma is increasing in Italy, indicating a need for revision of genetic assessment criteria. A study on Italian high-risk melanoma cases found that age, number of melanomas, pancreatic cancer, and region of origin are predictors of susceptibility variants.
Review
Oncology
Giuseppe Bronte, Vincenza Conteduca, Matteo Landriscina, Antonio Domenico Procopio
Summary: This meta-analysis demonstrates that high levels of circulating MDSCs are associated with worse overall survival in prostate cancer patients, supporting the importance of MDSC detection and targeting in this population.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Medicine, General & Internal
Davide Norata, Marta Peri, Giuseppe Roberto Giammalva, Antonino Lupica, Federica Paolini, Lorena Incorvaia, Giuseppe Badalamenti, Valerio Gristina, Antonio Galvano, Antonio Russo, Domenico Gerardo Iacopino, Mauro Silvestrini, Viviana Bazan, Filippo Brighina, Vincenzo Di Stefano
Summary: Von Hippel-Lindau (VHL) disease is an autosomal dominant condition that predisposes affected individuals to a variety of malignant and benign neoplasms. The accumulation of hypoxia-inducible factor (HIF)-1 alpha, a transcription factor involved in various biological processes, is the key turning point of this disease. Understanding the molecular pathways is important for targeted therapies and surgical intervention in VHL disease.
Article
Medicine, General & Internal
Daniela Cabibi, Antonino Giulio Giannone, Sandro Bellavia, Roberta Lo Coco, Anna Lo Bianco, Eleonora Formisano, Gregorio Scerrino, Giuseppa Graceffa
Summary: This study found a correlation between serum anti-thyroglobulin-antibodies (TgAb) and papillary thyroid carcinoma, as well as pre-neoplastic histological changes such as papillary-like nuclear features (PLNF) and lymphocytic infiltrate (LI). TgAb positivity can predict the presence of PLNF and LI. The expression of HBME1 in papillary thyroid carcinoma may indicate the presence of altered thyroglobulin triggering TgAb and LI.
Review
Medicine, Research & Experimental
Giuseppe Bronte, Luana Calabro, Fabiola Olivieri, Antonio Domenico Procopio, Lucio Crino
Summary: Immunotherapy is the main standard treatment for NSCLC patients. However, immune suppressive cells in the tumor microenvironment can counteract its efficacy. This systematic review and meta-analysis aimed to compare the prognosis between NSCLC patients with high and low levels of circulating MDSCs. The findings suggest that low levels of circulating MDSCs are associated with better progression-free survival (PFS)/recurrence-free survival (RFS) and overall survival (OS). Specifically, high levels of monocytic MDSCs (M-MDSCs) in peripheral blood are linked to a worse prognosis in NSCLC patients. Targeting this MDSC subset may help improve the efficacy of NSCLC treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Valerio Gristina, Nadia Barraco, Maria La Mantia, Luisa Castellana, Lavinia Insalaco, Marco Bono, Alessandro Perez, Delia Sardo, Sara Inguglia, Federica Iacono, Sofia Cutaia, Tancredi Didier Bazan Russo, Edoardo Francini, Lorena Incorvaia, Giuseppe Badalamenti, Antonio Russo, Antonio Galvano, Viviana Bazan
Summary: This study aims to explore the longitudinal plasma cfDNA kinetics as an early marker of therapeutic efficacy and disease relapse in patients with advanced NSCLC. The results demonstrate that quantitative changes in cfDNA values correlate with responses to therapy and relapse of disease.
Article
Oncology
Antonio Galvano, Luisa Castellana, Valerio Gristina, Maria La Mantia, Lavinia Insalaco, Nadia Barraco, Alessandro Perez, Sofia Cutaia, Valentina Calo, Tancredi Didier Bazan Russo, Edoardo Francini, Lorena Incorvaia, Mario Giuseppe Mirisola, Salvatore Vieni, Christian Rolfo, Viviana Bazan, Antonio Russo
Summary: The study compares the detection of PIK3CA mutations in plasma and tissue, and finds that ctDNA is a reliable method for detecting PIK3CA mutations in breast cancer. Next-generation sequencing-based ctDNA methods show the best performance in terms of sensitivity, specificity, and AUC, and sampling time may be a major cause of heterogeneity.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tommaso Vincenzo Bartolotta, Alessia Angela Maria Orlando, Mariangela Dimarco, Calogero Zarcaro, Fabiola Ferraro, Alessandra Cirino, Domenica Matranga, Salvatore Vieni, Daniela Cabibi
Summary: This study assessed the role of 2D-Shear Wave Elastography (2D-SWE) in distinguishing benign and malignant breast lesions and provided new vendor-specific cutoff values. The results showed that 2D-SWE parameters had higher diagnostic accuracy in breast ultrasound and could be used as an adjunctive assessment for breast masses.
Article
Gastroenterology & Hepatology
Kevin Bevant, Matthis Desoteux, Gaelle Angenard, Raphael Pineau, Stefano Caruso, Corentin Louis, Panagiotis Papoutsoglou, Laurent Sulpice, David Gilot, Jessica Zucman-Rossi, Cedric Coulouarn
Summary: FOXS1, a SMAD-dependent transcription factor induced by TGF-beta, regulates genes involved in EMT and is associated with poor prognosis in HCC and other cancers, making it a potential biomarker for targeted therapies.
HEPATOLOGY COMMUNICATIONS
(2022)