Article
Cell Biology
Yan Xue, Xueting Wang, Baolan Wan, Dongzhi Wang, Meiqi Li, Kang Cheng, Qianqian Luo, Dan Wang, Yapeng Lu, Li Zhu
Summary: This study found that CAV-1 plays a significant role in high-altitude cerebral edema (HACE). Under hypoxic conditions, CAV-1 expression is upregulated, leading to the disruption of the blood-brain barrier (BBB) and increased BBB permeability. NRF1 is a regulator of CAV-1. These findings provide important clues for identifying potential therapeutic targets for HACE.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Lina Bergman, Roxanne Hastie, Henrik Zetterberg, Kaj Blennow, Sonja Schell, Eduard Langenegger, Ashley Moodley, Susan Walker, Stephen Tong, Catherine Cluver
Summary: The study found evidence of neuroinflammation and an injured blood-brain barrier in women with preeclampsia and eclampsia, especially in those with eclampsia.
Review
Neurosciences
Yuhang Gu, Chen Zhou, Zhe Piao, Honghua Yuan, Huimin Jiang, Huimin Wei, Yifan Zhou, Guangxian Nan, Xunming Ji
Summary: Ischemic stroke is closely associated with increasing morbidity and is a leading cause of death and disability worldwide. Cerebral edema, a serious complication of ischemic stroke, remains poorly understood, hindering the advancement of prevention and treatment strategies. This review discusses the classification and pathological characteristics of cerebral edema, as well as the potential factors related to its development after ischemic stroke, providing a valuable reference for further research and clinical treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yanzhao Zhou, Feng Yan, Xue Han, Xin Huang, Xiang Cheng, Yanan Geng, Xiufang Jiang, Ying Han, Ming Zhao, Lingling Zhu
Summary: NB-3 plays an important role in neural development and injury recovery. It maintains the integrity of the blood brain barrier under high-altitude cerebral edema conditions. Deficiency of NB-3 leads to BBB leakage and downregulation of tight junction proteins, while overexpression or supplementation with NB-3 can alleviate endothelial barrier injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Yongqing Ye, Jin Xu, Yuhan Han
Summary: In this case report, it is speculated that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By adding dexamethasone to routine medication, a certain therapeutic effect has been achieved. Dexamethasone may maintain the stability of blood-brain barrier and reduce neuroinflammatory response and nerve injury through multiple pathways.
Article
Endocrinology & Metabolism
Ying-Chen Chen, Bing-Ze Lu, Yu-Chen Shu, Yuan-Ting Sun
Summary: This study found that cerebral microangiopathy with increased blood-brain barrier leakage occurs early in patients with type 2 diabetes mellitus (T2DM), before the appearance of cerebral small vessel disease (CSVD) on MRI. The involvement of white matter and gray matter is different in T2DM-related CSVD, and there are distinct features and mechanisms compared to other CSVDs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash, Sarah Y. Yuan
Summary: This study investigated the effects of lung infection on blood-brain barrier disruption and behavioral changes, and found that systemic bacterial infection may contribute to lung-brain axis inflammatory response through cytokine release.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Integrative & Complementary Medicine
Jeetprakash Barot, Bhagawati Saxena
Summary: The study demonstrates the neuroprotective effects of eugenol in a rat model of TBI, improving impaired locomotor function and short-term memory caused by trauma. Pretreatment with eugenol also alleviates histopathological, neurochemical, and behavioral consequences of the injury.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Review
Neurosciences
Xin-Ya Shen, Zhen-Kun Gao, Yu Han, Mei Yuan, Yi-Sha Guo, Xia Bi
Summary: Ischemic stroke leads to local brain tissue blood supply disorder, with astrocytes playing a crucial role in the response to the injury. Reactive astrocytes, activated after stroke, exhibit protective functions but also potentially harmful effects. Their spatial and temporal expression determines the diverse functions of astrocytes in the context of ischemic stroke's complex cascade reactions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Sichao Chen, Linqian Shao, Li Ma
Summary: Brain edema is a severe complication of stroke, associated with prolonged hospitalization and poor outcomes. The swelling of brain tissues affects perfusion and can lead to transtentorial herniation. The blood-brain barrier plays a crucial role in maintaining the stable microenvironment of the CNS, and dysfunction after conditions like ischemic stroke can contribute to cerebral vasogenic edema.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Yong Yang, Guoying Deng, Peng Wang, Guangzhao Lv, Rui Mao, Yuhao Sun, Baofeng Wang, Xijian Liu, Liuguan Bian, Dong Zhou
Summary: The porous Se@SiO2 nanocomposite exerts neuroprotective effects by suppressing oxidative stress, improving neurological function, reducing cell apoptosis, brain edema, and blood-brain barrier permeability in a collagenase-induced ICH mouse model. It may be a potential candidate for the clinical treatment of ICH and oxidative stress-related brain injuries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Neurosciences
Muyu Situ, Ali Francisco Citalan-Madrid, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic
Summary: The study reveals that Cerebral amyloid angiopathy (CAA) causes dysfunction of the blood-brain barrier (BBB), triggering intense proinflammatory responses and cognitive decline. Age exacerbates BBB injury in CAA vasculopathy, playing a significant role in the effects of amyloid beta (Aβ).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Shotaro Michinaga, Yutaka Koyama
Summary: Traumatic brain injury (TBI) is immediate damage to the brain caused by a blow to the head, resulting in death or serious disabilities. Astrocytes play a key role in the pathogenesis of TBI, with both beneficial and detrimental effects. They are attractive targets for novel therapeutic drugs for TBI, although such drugs have not yet been developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Haoan Wu, Bin Peng, Farrah S. Mohammed, Xingchun Gao, Zhenpeng Qin, Kevin N. Sheth, Jiangbing Zhou, Zhaozhong Jiang
Summary: This article reports the development of multifunctional polymeric nanoparticles for stroke treatment and drug delivery. The nanoparticles can penetrate ischemic brain tissue efficiently and exhibit excellent antioxidant activity. The study demonstrates the efficacy of the nanoparticles in delivering therapeutic agents for stroke treatment.
Article
Immunology
Yanan Geng, Junli Yang, Xiang Cheng, Ying Han, Feng Yan, Chengbo Wang, Xiufang Jiang, Xianhua Meng, Ming Fan, Ming Zhao, Lingling Zhu
Summary: In this study, GP-14 was found to effectively alleviate neuroinflammatory responses induced by hypoxia and LPS stimulation in a mouse model of HACE. GP-14 pretreatment inhibited microglial activation and protected the blood brain barrier integrity, suggesting its potential as a treatment option for HACE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Shina Kim, Joon-Tae Kim, Ji Sung Lee, Beom Joon Kim, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Sung-Il Sohn, Jeong-Ho Hong, Man-Seok Park, Kang-Ho Choi, Ki-Hyun Cho, Juneyoung Lee, Hee-Joon Bae
Summary: The study found that other combined antiplatelet treatment was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after acute ischaemic stroke, compared to aspirin alone or clopidogrel-aspirin. Further exploration in clinical trials will be necessary to determine the effectiveness of other combination treatments in preventing early vascular events in patients with acute minor stroke.
STROKE AND VASCULAR NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Seong Hwan Kim, Eun-Tae Jeon, Sungwook Yu, O. Kyungmi, Chi Kyung Kim, Tae-Jin Song, Yong-Jae Kim, Sung Hyuk Heo, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon-Tae Kim, Kang-Ho Choi, Yang Ha Hwang, Bum Joon Kim, Jong-Won Chung, Oh. Young Bang, Gyeongmoon Kim, Woo-Keun Seo, Jin-Man Jung
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
Jonguk Kim, Keon-joo Lee, Jun Yup Kim, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Kang-Ho Choi, Joon-Tae Kim, Dong-Ick Shin, Cha Jae-kwan, Dae-Hyun Kim, Dong-Eog Kim, Wi-Sun Ryu, Park Jong-moo, Kyusik Kang, Jae Kim, Soo Joo Lee, Mi-Sun Oh, Yong-Jin Cho, Jay Chol Choi, Sung il Sohn, Hong Jeong-ho, Tai Hwan Park, Kyung Bok Lee, Jee-hyun Kwon, Wook-Jo Kim, Jun Lee, Ji Sung Lee, Juneyoung Lee, Hee-joon Bae
Article
Multidisciplinary Sciences
Seong-Hwan Kim, Eun-Tae Jeon, Sungwook Yu, Kyungmi Oh, Chi Kyung Kim, Tae-Jin Song, Yong-Jae Kim, Sung Hyuk Heo, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon-Tae Kim, Kang-Ho Choi, Yang Ha Hwang, Bum Joon Kim, Jong-Won Chung, Oh Young Bang, Gyeongmoon Kim, Woo-Keun Seo, Jin-Man Jung
Summary: The study aimed to develop a novel prediction model for early neurological deterioration in atrial fibrillation-related stroke using an interpretable machine learning algorithm. The LightGBM model was most effective for predicting END, revealing new and diverse predictors. Feature importance analysis highlighted fasting glucose level and National Institute of Health Stroke Scale score as the most influential factors.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Wi-Sun Ryu, Keun-Sik Hong, Sang-Wuk Jeong, Jung E. Park, Beom Joon Kim, Joon-Tae Kim, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Man Seok Park, Kang-Ho Choi, Juneyoung Lee, Jeffrey L. Saver, Eng H. Lo, Hee-Joon Bae, Dong-Eog Kim
Summary: This study examines the association of stroke onset time with presenting severity, early neurological deterioration (END), and long-term functional outcome in human ischemic stroke. The findings suggest that night-onset strokes are associated with higher presenting neurologic severity, more frequent END, and worse 3-month functional outcome.
Article
Clinical Neurology
Hyunsoo Kim, Joon-Tae Kim, Ji Sung Lee, Beom Joon Kim, Jihoon Kang, Keon-Joo Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong-Ho Hong, Sang-Hwa Lee, Man-Seok Park, Kang-Ho Choi, Juneyoung Lee, Hee-Joon Bae
Summary: This study describes the general characteristics, management, and outcomes of stroke in other determined etiology (OE) and its subgroups. The study found that arterial dissection, intrinsic diseases of the arterial wall, and stroke associated with migraine and drugs were more likely to occur at a young age, while disorders of platelets and the hemostatic system, cancer-related coagulopathy, infectious diseases, and hypoperfusion syndromes were more frequent at an old age. The composite of stroke and all-cause mortality within 1 year was highest in cancer-related coagulopathy, and lowest in stroke associated with migraine and drugs and arterial dissection.
Article
Cardiac & Cardiovascular Systems
Keon-Joo Lee, Beom Joon Kim, Moon-Ku Han, Joon-Tae Kim, Kang-Ho Choi, Dong-Ick Shin, Jae-Kwan Cha, Dae-Hyun Kim, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Keun-Sik Hong, Yong-Jin Cho, Jay Chol Choi, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jee-Hyun Kwon, Wook-Joo Kim, Sung Il Sohn, Jeong-Ho Hong, Jun Lee, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee-Joon Bae
Summary: This study found that heart rate during the acute period of ischemic stroke can predict subsequent major clinical events, with maximum heart rate being the best predictor. Patients with heart rates above specific cutoff points are at higher risk of the primary outcome. These findings highlight the importance of heart rate control in preventing subsequent cardiovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Keon-Joo Lee, Beom Joon Kim, Moon-Ku Han, Joon-Tae Kim, Kang Ho Choi, Dong-Ick Shin, Jae-Kwan Cha, Dae-Hyun Kim, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Keun-Sik Hong, Yong-Jin Cho, Jay Chol Choi, Tai Hwan Park, Sang-Soon Park, Jee-Hyun Kwon, Wook-Joo Kim, Jun Lee, Sung Il Sohn, Jeong-Ho Hong, Kyung Bok Lee, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee-Joon Bae
Summary: This study analyzed the long-term trajectory of blood pressure and its influence on outcomes in patients with acute ischemic stroke. Four trajectories of systolic blood pressure were identified, and patients in the slowly dropping and persistently high trajectory groups were prone to adverse cardiovascular outcomes after stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Cindy W. Yoon, Hoonji Oh, Juneyoung Lee, Joung-Ho Rha, Seong-Ill Woo, Won Kyung Lee, Han-Young Jung, Byeolnim Ban, Jihoon Kang, Beom Joon Kim, Won-Seok Kim, Chang-Hwan Yoon, Heeyoung Lee, Seongheon Kim, Sung Hun Kim, Eun Kyoung Kang, Ae-Young Her, Jae-Kwan Cha, Dae-Hyun Kim, Moo-Hyun Kim, Jang Hoon Lee, Hun Sik Park, Keonyeop Kim, Rock Bum Kim, Nack-Cheon Choi, Jinyong Hwang, Hyun-Woong Park, Ki Soo Park, SangHak Yi, Jae Young Cho, Nam-Ho Kim, Kang-Ho Choi, Yongcheol Kim, Juhan Kim, Jae-Young Han, Jay Chol Choi, Song-Yi Kim, Joon-Hyouk Choi, Jei Kim, Sung Ju Jee, Min Kyun Sohn, Si Wan Choi, Dong-Ick Shin, Sang Yeub Lee, Jang-Whan Bae, Kunsei Lee, Hee-Joon Bae
Summary: This study compares prehospital delay and related factors between acute ischemic stroke (AIS) and acute myocardial infarction (AMI) patients. The use of emergency medical services was identified as a key determinant of delayed arrival in both groups. Various factors, such as age, sex, symptom severity, and presentation time, had different effects on delayed arrival between AIS and AMI. These findings suggest the need for differentiated strategies to reduce prehospital delay.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ki-Woong Nam, Chi Kyung Kim, Sungwook Yu, Kyungmi Oh, Jong-Won Chung, Oh Young Bang, Gyeong-Moon Kim, Jin-Man Jung, Tae-Jin Song, Yong-Jae Kim, Bum Joon Kim, Sung Hyuk Heo, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon-Tae Kim, Kang-Ho Choi, Yang Ha Hwang, Woo-Keun Seo
Summary: This study evaluated the association between tHcy levels and functional outcomes in patients with AF-related stroke. The results showed that higher tHcy levels were associated with unfavorable outcomes, but this association may vary depending on renal function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemical Research Methods
Nizar Guezzi, Changho Lee, Thanh Dat Le, Hyojin Seong, Kang-Ho Choi, Jung-Joon Min, Jaesok Yu
Summary: Photoacoustic microscopy is a popular imaging technique due to its high optical resolution contrast, good spatial resolution, and deep depth. However, photoacoustic images often suffer from noise, which can be removed using filtering techniques. In this study, a combination of filters was proposed to enhance the signal-to-noise ratio and preserve image details.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Nursing
Sung-Hee Yoo, Gye-Gyoung Kim, Sung Reul Kim, Man-Seok Park, Joon-Tae Kim, Kang-Ho Choi, Hyun-Young Park, Sang-Hak Yi, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah
Summary: Among Korean stroke survivors, medication persistence and adherence at three months and one year were relatively good. Medication belief and three-month medication adherence were important factors predicting three-month adherence and one-year adherence, respectively.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Multidisciplinary Sciences
You-Ri Kang, Joon-Tae Kim, Ji Sung Lee, Beom Joon Kim, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Dong-Eog Kim, Wi-Sun Ryu, Jay Chol Choi, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Sung Il Sohn, Jeong-Ho Hong, Man-Seok Park, Kang-Ho Choi, Ki-Hyun Cho, Jong-Moo Park, Sang-Hwa Lee, Juneyoung Lee, Hee-Joon Bae
Summary: This study investigated the influence of low-density lipoprotein cholesterol (LDL-C) levels on functional outcomes after intravenous thrombolysis (IVT), depending on whether statins were used before stroke. The results showed that LDL-C levels were not associated with a 3-month good outcome, but the use of statins before stroke could modify the influence of LDL-C levels on functional outcomes after IVT.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Dae-Hyun Kim, Seok-Joo Moon, Juneyoung Lee, Jae-Kwan Cha, Moo Hyun Kim, Jong-Sung Park, Byeolnim Ban, Jihoon Kang, Beom Joon Kim, Won-Seok Kim, Chang-Hwan Yoon, Heeyoung Lee, Seongheon Kim, Eun Kyoung Kang, Ae-Young Her, Cindy W. Yoon, Joung-Ho Rha, Seong-Ill Woo, Won Kyung Lee, Han -Young Jung, Jang Hoon Lee, Hun Sik Park, Yang-Ha Hwang, Keonyeop Kim, Rock Bum Kim, Nack-Cheon Choi, Jinyong Hwang, Hyun-Woong Park, Ki Soo Park, SangHak Yi, Jae Young Cho, Nam-Ho Kim, Kang-Ho Choi, Juhan Kim, Jae-Young Han, Jay Chol Choi, Song-Yi Kim, Joon-Hyouk Choi, Jei Kim, Min Kyun Sohn, Si Wan Choi, Dong-Ick Shin, Sang Yeub Lee, Jang-Whan Bae, Kun Sei Lee, Hee-Joon Bae
Summary: Factors associated with direct admission to regional cardiocerebrovascular centers differed between acute ischemic stroke (AIS) and acute myocardial infarction (AMI). The use of emergency medical service (EMS) was found to be a crucial factor in determining hospital admission for both conditions.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Keon-Joo Lee, Dong Woo Shin, Hong-Kyun Park, Beom Joon Kim, Jong-Moo Park, Kyusik Kang, Tai Hwan Park, Kyung Bok Lee, Keun-Sik Hong, Yong-Jin Cho, Dong-Eog Kim, Wi-Sun Ryu, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Soo Joo Lee, Jae Guk Kim, Jun Lee, Jae-Kwan Cha, Dae-Hyun Kim, Joon-Tae Kim, Kang-Ho Choi, Jay Chol Choi, Eva Lesen, Jonatan Hedberg, Amarjeet Tank, Edmond G. Fita, Ji Eun Song, Ji Sung Lee, Juneyoung Lee, Hee-Joon Bae
Summary: This study aimed to provide the prognosis after minor acute ischemic stroke or transient ischemic attack, using a definition of subsequent stroke in accordance with recent clinical trials. The study found that the risk of subsequent events shortly after a minor acute ischemic stroke or high-risk transient ischemic attack was substantial, particularly in patients with large artery atherosclerosis.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)