Article
Immunology
Wei Zhang, Lu Xiang, Peng Luo, Dili Xie
Summary: Cardiovascular aging is a significant factor contributing to cardiovascular disease, and alpha-lactalbumin has been found to have anti-aging potential in attenuating cardiovascular aging, inflammation, and oxidative stress. Both in vitro and in vivo experiments support this finding, suggesting that alpha-lactalbumin could be a promising anti-aging functional food in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Jazmin A. Cole, Mackenzie N. Kehmeier, Bradley R. Bedell, Sahana Krishna Kumaran, Grant D. Henson, Ashley E. Walker
Summary: Vascular endothelial function declines with age, but there is variability in this decline across individuals. Frailty index can be used as a surrogate for biological age, and this study found that frailty is related to age-related decline in vascular function, but the relationship is dependent on sex and the artery examined. Arterial oxidative stress and proinflammatory signaling may mediate the relationship between frailty and endothelial function.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Genetics & Heredity
Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wan
Summary: Previous studies have shown the importance of bone morphogenetic proteins (BMPs) in cardiovascular diseases. In this study, the role of Kielin/chordin-like protein (KCP) in cardiac aging was investigated. The results demonstrated that KCP knockout aggravated cardiac aging by increasing oxidative stress, inflammation, and cardiomyocyte apoptosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Emily Ho, Carmen P. Wong, Janet C. King
Summary: Dr. Bruce Ames pioneered the understanding of oxidative stress, DNA damage, and the connection between micronutrient deficiencies and DNA damage. Zinc is essential for human health, playing a critical role in cellular antioxidant defense, DNA integrity, and immune function. Studies have shown that zinc deficiency is associated with oxidative stress, susceptibility to DNA damage, and chronic inflammation, emphasizing the importance of adequate nutrition for healthy aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Rocio Brea, Pilar Valdecantos, Patricia Rada, Rosa Alen, Carmelo Garcia-Monzon, Lisardo Bosca, Marina Fuertes-Agudo, Marta Casado, Paloma Martin-Sanz, Angela M. Valverde
Summary: The chronic infratherapeutic APAP treatment protects mice from age-related liver alterations by attenuating oxidative stress and inflammation.
Review
Pharmacology & Pharmacy
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Renal aging is a degenerative process associated with harmful accumulation. Mitochondria, the energy factories of the cell, play important roles in renal aging through abnormal mitochondrial homeostasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hollie Speer, Andrew J. McKune
Summary: Hypertension is a major risk factor for cardiovascular diseases, and studying the factors involved in its progression is crucial for healthy aging. Aging is associated with a loss of skeletal muscle quantity and quality, as well as an increase in Reactive Oxygen and Nitrogen Species, which may accelerate the aging process.
Review
Cell Biology
Maria Eugenia Matzkin, Ricardo Saul Calandra, Soledad Paola Rossi, Andrzej Bartke, Monica Beatriz Frungieri
Summary: The male reproductive system undergoes aging primarily affecting the testes, resulting in decreased sexual hormone levels, altered sperm quality, and reduced fertility. Inflammation, oxidation, and apoptosis are predictors of aging-related diseases, with pro-inflammatory molecules and reactive oxygen species identified as contributing factors for testicular aging. The impact of age-related testicular changes on fertility, reproductive health, and lifespan remains incompletely understood, motivating research into anti-aging interventions and therapies utilizing pharmaceuticals or natural alternatives with anti-inflammatory, antioxidant, and anti-apoptotic properties.
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Article
Plant Sciences
Jimei Zhang, Chonghong Zhang, Li Miao, Zimin Meng, Ning Gu, Guifang Song
Summary: This study explored the potential advantages of stigmasterol in asthma and found that it has anti-inflammatory and antioxidative stress effects. The results showed that stigmasterol can inhibit inflammation infiltration and mucus hypersecretion, and decrease NK1-R expression, providing a theoretical basis and more possibilities for the treatment of asthma.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Immunology
Jiali Fang, Yuhe Guo, Wei Yin, Lei Zhang, Guanghui Li, Junjie Ma, Lu Xu, Yunyi Xiong, Luhao Liu, Weiting Zhang, Zheng Chen
Summary: In this study, the potential therapeutic effects of neoxanthin on chronic renal failure were investigated. It was found that neoxanthin could delay the progression of the disease and alleviate aging and fibrosis caused by chronic renal failure.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Piyush Sharma, Raj Kumar Yadav, Rajesh Khadgawat, Rima Dada
Summary: This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care on the expression of genes related to oxidative stress, inflammation, and aging in obese adults. The results suggest a positive impact of yoga-based intervention on the expression of aging-related genes in obesity, although this benefit was not evident till week 12.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xin Han, Chuan Ding, Xianan Sang, Mengyun Peng, Qiao Yang, Yan Ning, Qiang Lv, Qiyuan Shan, Min Hao, Kuilong Wang, Xin Wu, Hongyan Zhang, Gang Cao
Summary: Fibrosis, a wound-healing response characterized by excessive deposition of extracellular matrix, is closely related to aging, oxidative stress, and inflammation. Sirtuin-1 (SIRTI), a histone deacetylase, plays critical roles in regulating growth, transcription, aging, and metabolism in various organs. This review provides an overview of fibrosis and the regulatory functions of SIRTI, summarizes its relationships with other proteins, and discusses its protective actions during fibrosis in different organs. The activation of SIRTI in therapies for tissue fibrosis, specifically in liver fibrosis and aging-related tissue injury, is analyzed. Targeting SIRTI may present a novel therapeutic strategy for fibrosis.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Behavioral Sciences
Aliabbas Zia, Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Aging is the primary risk factor for age-related diseases such as neurodegenerative disorders, understanding the mechanisms behind aging is crucial for brain health. Brain aging is characterized by a decline in neurophysiological functions, impaired neuroplasticity, dysregulation of neuronal Ca2+ homeostasis, and other factors. Various pathways contribute to brain aging, including oxidative stress, inflammation, energy metabolism disturbances, and the involvement of key modulators in metabolic control.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Medicine, Research & Experimental
Guoding Cao, Monan Lin, Wei Gu, Zaiyu Su, Yagan Duan, Wuqi Song, Hailiang Liu, Fengmin Zhang
Summary: The FOX family of transcription factors, including the FOXA to FOXS subfamilies, play important roles in various biological processes. FOXO3, a member of the FOXO subfamily, has diverse biological effects that are primarily regulated by its phosphorylation. Phosphorylation of FOXO3 affects its subcellular localization and transcriptional activity, and it is involved in various biological processes such as inflammation, autophagy, apoptosis, and DNA damage repair. Moreover, FOXO3 also contributes to the development of diseases and the aging process, and targeting FOXO3 may offer new therapeutic strategies for age-related diseases and longevity.