Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Gastroenterology & Hepatology
Pavan Dhoble, Philip Abraham, Devendra Desai, Anand Joshi, Tarun Gupta, Shachish Doctor, Anand Deshpande, Rajeshwari Basavanna
Summary: In a region in India where mixed-cereal diets are common, 11% of patients with IBS self-reported wheat sensitivity, with none having positive celiac serology. Most patients showed symptomatic improvement on a wheat-free diet.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Christian Bojarski, Paul Tangermann, Christian Barmeyer, Juliane Buchkremer, Ralf Kiesslich, Mark Ellrichmann, Stefan Schreiber, Carsten Schmidt, Andreas Stallmach, Robert Roehle, Christoph Loddenkemper, Severin Daum, Britta Siegmund, Michael Schumann, Reiner Ullrich
Summary: The study evaluated the diagnostic accuracy of confocal laser endomicroscopy for identifying wheat sensitivity in patients with IBS, showing low sensitivity and specificity.
Article
Nutrition & Dietetics
Michele J. Alkalay
Summary: Lactose malabsorption, celiac disease, non-celiac gluten sensitivity, and irritable bowel syndrome are conditions associated with food triggers and can cause nutritional detriments. This review provides an overview of the complex nutritional elements of these disorders, which is critical for medical providers to recognize.
Article
Nutrition & Dietetics
Elise Nordin, Per M. Hellstrom, Johan Dicksved, Erik Pelve, Rikard Landberg, Carl Brunius
Summary: This study investigated the effects of FODMAPs and gluten on gut microbiota and circulating metabolite profiles, as well as the potential links between microbiota, metabolites, and IBS symptoms. The results showed that FODMAPs altered microbiota composition and were correlated with phenolic-derived metabolites and 3-indolepropionate, which are associated with positive health factors. However, the associations between molecular data and IBS symptoms were weak.
Article
Nutrition & Dietetics
Valentina Ponzo, Ilario Ferrocino, Ilaria Goitre, Marianna Pellegrini, Mauro Bruno, Marco Astegiano, Gianni Cadario, Eleonora Castellana, Fabio Bioletto, Maria Rita Corvaglia, Patrizia Malfa, Luca Cocolin, Ezio Ghigo, Simona Bo
Summary: By conducting a double-blind placebo-controlled gluten challenge test, this study found that almost half of individuals suspected of gluten sensitivity reported symptoms even with the placebo. These individuals showed lower mental health scores, increased risk for eating disorders, and a different gut microbiota composition compared to placebo-responsive participants.
Review
Gastroenterology & Hepatology
William D. Chey, Laurie Keefer, Kevin Whelan, Peter R. Gibson
Summary: Irritable bowel syndrome (IBS) is a common condition that affects quality of life and costs healthcare systems billions of dollars annually. In addition to medication, behavioral techniques and dietary modifications are effective in treating IBS.
Article
Health Care Sciences & Services
Joanna B. Bierla, Bozena Cukrowska, Barbara Skrzydlo-Radomanska, Beata Prozorow-Krol, Anetta Kurzeja-Miroslaw, Halina Cichoz-Lach, Katarzyna Laskowska, Agnieszka Sowinska, Emilia Majsiak
Summary: The aim of this study was to determine the frequency of various antibodies in adult patients with diarrhea-predominant IBS (IBS-D), indicating the need for serological tests in this group. The study found a high percentage of positive results for the tested antibodies, suggesting possible overlap with other gastrointestinal disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Article
Nutrition & Dietetics
Elise Nordin, Carl Brunius, Rikard Landberg, Per M. Hellstrom
Summary: This study found that a diet rich in FODMAPs had a modest effect on IBS symptoms, while gluten had no effect on IBS symptoms. The study also revealed significant individual differences in response to different interventions.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Susana Sanchez-Leon, Carmen Haro, Myriam Villatoro, Luis Vaquero, Isabel Comino, Ana B. Gonzalez-Amigo, Santiago Vivas, Jorge Pastor, Carolina Sousa, Blanca B. Landa, Francisco Barro
Summary: The study found that gastrointestinal symptoms of NCWS patients did not significantly change between gluten-free bread and tritordeum bread. Participants rated tritordeum bread higher than gluten-free bread in terms of acceptability. Analysis of the gut microbiota showed that tritordeum consumption does not alter the global structure and composition of the intestinal microbiota.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Nutrition & Dietetics
Luis Alberto Sanchez-Vargas, Karina Guadalupe Hernandez-Flores, Francisco Javier Cabrera-Jorge, Jose Maria Remes-Troche, Job Reyes-Huerta, Hector Vivanco-Cid
Summary: Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by dietary gluten, while irritable bowel syndrome (IBS) is a functional gastrointestinal disorder affecting the large intestine. Research reveals a higher prevalence of IgA antibodies to maize zeins (AZA) in newly diagnosed CD patients compared to IBS patients, indicating a biased immune response to gliadin-related prolamins in genetically susceptible individuals.
Review
Nutrition & Dietetics
Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Maria de Lourdes Moreno
Summary: The only current treatment for celiac disease is a strict gluten-free diet, but there is a need for non-dietary alternatives to prevent damage from dietary transgressions. Recent therapies for CD focus on degrading gluten, regulating the immune response, and inducing immunological tolerance, with promising results seen in some phase III and II clinical trials.
Review
Nutrition & Dietetics
Jongsung Hahn, Jeongwon Choi, Min Jung Chang
Summary: This meta-analysis revealed that a low fermentable oligo-, di-, monosaccharides, and polyols diet (LFD) has a moderate reduction effect on the symptom severity and a slight improvement effect on the quality of life of irritable bowel syndrome (IBS) patients, as well as a significant improvement in stool habits.
Review
Food Science & Technology
Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flavio Eduardo Dias Araujo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitoria Cota de Abreu, Janaina Koenen Fonseca, Renato Guimaraes Loffi, Giselle Foureaux
Summary: Gluten, the most common protein in wheat, is associated with celiac disease, wheat allergy, and non-celiac gluten sensitivity. These disorders have similar clinical manifestations but differ in development pathways and diagnostic criteria. A gluten-free diet is the most effective treatment for celiac disease and may also lead to improvements in neuropathologies and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)