Article
Pediatrics
Emilia Villamil, Claudio Rodriguez-Camejo, Arturo Puyol, Laura Fazio, Valentina Colistro, Ana Hernandez
Summary: The study found differences in the immune profile of breast milk produced by mothers with celiac disease compared to healthy mothers, which may explain previous controversies regarding the protective effect of breastfeeding on celiac disease. Despite long-term adherence to a gluten-free diet, breast milk from mothers with celiac disease still exhibited a unique immune profile.
PEDIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Wei Wu, Adi Balter, Victoria Vodsky, Yatreb Odetallh, Gai Ben-Dror, Yumei Zhang, Ai Zhao
Summary: Regional differences exist in breast milk composition. The most predominant TAG in Chinese breast milk is OPL, followed by OPO, with LA and OA being the main fatty acids. LA content is positively associated with the consumption of soybeans and soybean products, while OA content is negatively correlated with soybean products, livestock and poultry meat, nuts, and cooking oil consumption. Different food groups have varying effects on fatty acid composition.
FRONTIERS IN NUTRITION
(2021)
Article
Psychiatry
Juliette Rodriguez, Marie Rose Moro, Rahmeth Radjack
Summary: This qualitative study explores the subjective experiences of first-generation migrant women who gave birth by Caesarean section. The women's experiences of Caesarean section include shock, psychological suffering due to isolation and loneliness, negative preconceptions, and the importance of continuity of care.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Qiu-Ye Lan, Si-Yu Huang, Chen-Yu Jiang, Meng-Tao Yang, Tong Wu, Xiao-Yan Chen, Zhao-Yan Liu, Wei Wei, Xing-Guo Wang, Hui-Lian Zhu
Summary: This study analyzed the molecular species of TAG in human milk fat and its changes during lactation using UPLC-Q-TOF-MS. The results showed that the changes in TAG mainly occurred in the early stages of lactation, and the TAG profile became stable after 200 days of lactation. Odd chain fatty acids may be important markers for identifying different lactation stages.
Review
Immunology
Gatien A. G. Lokossou, Leonce Kouakanou, Anne Schumacher, Ana C. Zenclussen
Summary: Breastfeeding has long-term benefits for both children and mothers, reducing the risks of infectious and non-communicable diseases. The components in breast milk play important roles in disease protection and immune system development in newborns.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Silvia Sanchez-Hernandez, Laetitia Theron, Pablo Jimenez-Barrios, Manuel Olalla-Herrera, Isidra Recio, Beatriz Miralles
Summary: The study evaluated the protein profile of human milk from mothers with normal weight and those who are overweight or obese, identifying differences in protein expression and successfully classifying lactation state and milk profile according to the mother's condition. Additionally, an in vitro digestion model was used to consider and study newborns' gastrointestinal conditions.
Article
Microbiology
Kunming Zhang, Min Jin, Dong Yang, Zhiqiang Shen, Weili Liu, Jing Yin, Zhongwei Yang, Huaran Wang, Danyang Shi, Jiping Yang, Haibei Li, Yaqiong Chen, Zhixian Gao, Zhigang Qiu, Haixia Shi, Jun-Wen Li
Summary: The human gut contains a high number of antibiotic resistance genes (ARGs), even in the absence of antibiotics. This study investigated the acquisition of ARGs in caesarean section newborns and found that these genes mainly came from colostrum and partly from the hospital environment.
Article
Environmental Sciences
Ting Luo, Jin Guo Hang, Shoji F. Nakayama, Chau-Ren Jung, Chao Chen Ma, Teruhiko Kido, Feng Hua Wang, Zheng Wang, Jing Jian Dong, Li Li Shi, Xian Liang Sun
Summary: Studies in China have shown significantly higher levels of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs) in breast milk from women living in e-waste recycling sites compared to those in reference sites. The total toxic equivalents (TEQ) of PCDDs/DFs were found to be twice as high in the exposed group.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, General & Internal
Yi Liu, Jie Xiang, Jianhua Ren, Li Gu, Yu Wang, Xiuping Liu, Jiao Wen
Summary: This study aimed to explore the influencing factors of gastrointestinal function recovery after cesarean section (CS). The study found that parity, type of CS, 2-hours bleeding after surgery, time of first meal after surgery, and whether taking peppermint water after surgery were independent factors affecting gastrointestinal function recovery after CS.
Article
Multidisciplinary Sciences
Neeraj Puro, Reena J. Kelly, Mandar Bodas, Scott Feyereisen
Summary: This study reveals that the rate of C-sections is higher among expectant mothers covered by private insurance compared to those covered by public insurance. Although the majority of the difference in C-section rates remains unexplained (approximately 66.3%), advancing maternal age and socioeconomic status of the expectant mother contribute to the remaining 33.7% difference.
Article
Environmental Sciences
Ju Hee Kim, Nalae Moon, Jae-Won Lee, Qaim Mehdi, Myoung-Hee Yun, Hyo-Bang Moon
Summary: Many studies have found that neonates and infants are exposed to PFASs through breastfeeding, but these studies have had small sample sizes. This study aimed to determine PFAS concentrations in breast milk and identify factors influencing their levels. The findings showed that 12 out of 14 PFASs were detectable in breast milk samples, and the concentrations were higher than reported in other studies. Factors such as body mass index, living area, neonatal age, and frequency of fish, ice cream, and canned food consumption were found to be associated with PFAS concentrations.
Article
Nutrition & Dietetics
Young Eun Cho, Rany Vorn, Michael Chimenti, Keith Crouch, Chen Shaoshuai, Janhavi Narayanaswamy, Alaria Harken, Reegan Schmidt, Jessica Gill, Hyangkyu Lee
Summary: In this study, we investigated the altered miRNAs in bEVs of mothers with obesity and their potential impact on breastfed infants.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Abha Cherkani-Hassani, Meriem Slaoui, Imane Ghanname, Brahim Mojemmi, Rachid Eljaoudi, Abdelilah Belhaj, Brahim Kers, Majda Flayou, Nezha Mouane
Summary: The CONTAMILK study aimed to estimate contamination levels of breast milk in Moroccan nursing mothers by lead and other xenobiotics, identify associated factors, and determine newborns' daily intake. Lead concentrations in colostrum samples were found to be higher than the normal range, with factors such as preterm delivery and cosmetic usage significantly influencing the levels. Some babies had daily intake levels exceeding the tolerable daily intake set by European food safety authority and WHO.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Sobhy M. Yakout, Ahmed M. Isa, Amel A. El-Sayed, Mohamed H. EL-Saeid
Summary: This study presents the temporal changes of decabromodiphenyl ether (decaBDE) in Saudi human breast milk samples for the first time. Through analysis using gas chromatography-mass spectrometry, it was found that the predominant congeners were BDE-209, -28, -138, and -208. BDE-209 was detected in all analyzed samples, indicating recent exposure of mothers to deca-BDE. The study also suggests that eggs may be a source of BDE-28 in the bodies of mothers. Overall, the study highlights the health concerns and the need for further research on the exposure and effects of decaBDE. Rating: 8 out of 10.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Environmental Sciences
Qun Gao, Yumin Niu, Bin Wang, Jiaying Liu, Yunfeng Zhao, Jing Zhang, Yang Wang, Bing Shao
Summary: This study in Hunan, China found BPA concentrations in breast milk samples from 149 lactating mothers, with different TDIs for infants and lactating mothers. The study revealed a temporal decline trend in BPA concentrations in breast milk.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Clara L. Garcia-Rodenas, Carlos A. De Castro, Rosemarie Jenni, Sagar K. Thakkar, Lydie Beauport, Jean-Francois Tolsa, Celine J. Fischer-Fumeaux, Michael Affolter
CLINICAL NUTRITION
(2019)
Article
Obstetrics & Gynecology
Francesca Giuffrida, Sean Austin, Denis Cuany, Belen Sanchez-Bridge, Karin Longet, Emmanuelle Bertschy, Julien Sauser, Sagar K. Thakkar, Le Ye Lee, Michael Affolter
JOURNAL OF PERINATOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
C. Fuerer, R. Jenni, L. Cardinaux, F. Andetsion, S. Wagniere, J. Moulin, M. Affolter
JOURNAL OF DAIRY SCIENCE
(2020)
Article
Nutrition & Dietetics
Magalie Sabatier, Clara L. Garcia-Rodenas, Carlos A. De Castro, Peter Kastenmayer, Mario Vigo, Stephane Dubascoux, Daniel Andrey, Marine Nicolas, Janique Richoz Payot, Valentine Bordier, Sagar K. Thakkar, Lydie Beauport, Jean-Francois Tolsa, Celine J. Fischer Fumeaux, Michael Affolter
Review
Biochemical Research Methods
Loic Dayon, Michael Affolter
EXPERT REVIEW OF PROTEOMICS
(2020)
Article
Nutrition & Dietetics
Tinu Mary Samuel, Carlos Antonio De Castro, Stephane Dubascoux, Michael Affolter, Francesca Giuffrida, Claude Billeaud, Jean-Charles Picaud, Massimo Agosti, Isam Al-Jashi, Almerinda Barroso Pereira, Maria Jose Costeira, Maria Gorett Silva, Giovanna Marchini, Thameur Rakza, Kirsti Haaland, Tom Stiris, Silvia-Maria Stoicescu, Cecilia Martinez-Costa, Mireilla Vanpee, Magnus Domellof, Euridice Castaneda-Gutierrez, Sagar Kiran Thakkar, Irma Silva-Zolezzi
Article
Nutrition & Dietetics
Karine Redeuil, Antoine Leveques, Jean-Marie Oberson, Sylvie Benet, Emeline Tissot, Karin Longet, Antonio de Castro, Celine Romagny, Lydie Beauport, Celine J. Fischer Fumeaux, Jean-Francois Tolsa, Michael Affolter, Esther Campos Gimenez, Clara L. Garcia-Rodenas, Sagar K. Thakkar
Summary: This study found that some vitamin levels in breast milk for preterm infants may be higher compared to term infants, particularly in the first two weeks postpartum, while carotenoids may have higher concentrations in term milk between weeks 1 and 4 postpartum.
CLINICAL NUTRITION
(2021)
Article
Pediatrics
Alexandra Adam-Darque, Lorena Freitas, Frederic Grouiller, Julien Sauser, Francois Lazeyras, Dimitri Van de Ville, Philippe Pollien, Clara L. Garcia-Rodenas, Gabriela Bergonzelli, Petra S. Hueppi, Russia Ha-Vinh Leuchter
Summary: The study investigates the neural mechanisms of infant colic by examining newborns' brain responses to sensory stimuli, finding that infants who develop colic exhibit distinct brain activation patterns compared to non-colicky infants. This early sensitivity to stimuli explains a significant portion of subsequent crying behavior. The findings have implications for understanding and potentially advising families with colicky infants.
PEDIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Jane M. Natividad, Andreas Rytz, Sonia Keddani, Gabriela Bergonzelli, Clara L. Garcia-Rodenas
Article
Nutrition & Dietetics
Veronica Caldeo, Eimear Downey, Carol-Anne O'shea, Michael Affolter, Sheri Volger, Marie-Claude Courtet-Compondu, Carlos Antonio De Castros, James A. O'Mahony, C. Anthony Ryan, Alan L. Kelly
Summary: This study evaluated the composition, protein profile, and plasmin activity of human milk from mothers who delivered infants at different gestational ages. Results showed that protein content and levels of some individual proteins were significantly affected by gestational age at birth and duration of lactation, with differences in proteolytic activity in milk samples. Compositional differences between term and pre-term infant milk were most significant in terms of protein profile.
CLINICAL NUTRITION
(2021)
Article
Biochemical Research Methods
Loic Dayon, Charlotte Macron, Sabine Lahrichi, Antonio Nunez Galindo, Michael Affolter
Summary: A highly automated proteomic workflow for human milk sample analysis was developed, utilizing liquid chromatography mass spectrometry. Different workflows were evaluated and optimized, with the aim of allowing analysis of large sample cohorts in clinical research. This efficient workflow provides a new approach to studying the proteome of human milk.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Nutrition & Dietetics
Tristan Bourdeau, Michael Affolter, Lenaick Dupuis, Alexandre Panchaud, Sabine Lahrichi, Loraine Merminod, Christine Martin-Paschoud, Rachel Adams, Sophie Nutten, Carine Blanchard
Summary: Human clinical trials have demonstrated that a specific partially hydrolyzed 100% whey-based infant formula can reduce atopic dermatitis risk in the first year of life. However, differences in peptide composition and functional properties were found among different formulas, indicating that not all formulas have the same ability to reduce allergenicity and induce oral tolerance.
Review
Biochemical Research Methods
Loic Dayon, Ornella Cominetti, Michael Affolter
Summary: Biological fluids, such as blood and cerebrospinal fluid, are important samples for diagnostic testing and monitoring. Proteomic technologies have been used to identify protein biomarkers in these fluids, but with limited success. Recent advancements in technology and methodologies have allowed for better analysis of human biological fluids, and this review focuses on recent highlights in the field of proteomics using mass spectrometry. Despite being overshadowed by genomics, proteomic tools and methodologies have matured and are now better suited for discovering innovative and robust biofluid biomarkers.
EXPERT REVIEW OF PROTEOMICS
(2022)
Article
Agriculture, Dairy & Animal Science
Holger A. Ebhardt, Pierre Ponchon, Konstantinos Theodosiadis, Christophe Fuerer, Marie -Claude Courtet-Compondu, Jonathan O'Regan, Michael Affolter, Yousef Joubran
Summary: High resolution mass spectrometry can identify hundreds to thousands of proteins per sample with label-free quantification, but the gold standard for quantitative proteomics is MRM. The authors demonstrate a reductionist approach using correlation analysis of dairy ingredients, successfully explaining variance in proteomics data with only 9 proteins. Their method, Trinity-MRM, shows reproducibility below 5% in independent experiments with double cream.
JOURNAL OF DAIRY SCIENCE
(2022)
