The intricate dance of post-translational modifications in the rhythm of life

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

(2016) Xuan Zhao et al.   CELL

APERIOD3variant causes a circadian phenotype and is associated with a seasonal mood trait

(2016) Luoying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking

(2016) Stefania Militi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cryptochrome 2 mutation yields advanced sleep phase in humans

(2016) Arisa Hirano et al.   eLife

USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock

(2016) Arisa Hirano et al.   PLoS One

Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer

(2015) L. Fang et al.   MOLECULAR CANCER THERAPEUTICS

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

(2015) Neel Mehta et al.   Cell Reports

CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

(2015) Teruya Tamaru et al.   PLOS BIOLOGY

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

(2015) Xin Tong et al.   PLoS One

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

The Mammalian Circadian Clock Protein Period Counteracts Cryptochrome in Phosphorylation Dynamics of Circadian Locomotor Output Cycles Kaput (CLOCK)

(2014) Ritsuko Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Role of Phosphorylation of Cryptochrome 2 in the Mouse Circadian Clock

(2014) A. Hirano et al.   MOLECULAR AND CELLULAR BIOLOGY

CLOCK-Controlled Polyphonic Regulation of Circadian Rhythms through Canonical and Noncanonical E-Boxes

(2014) H. Yoshitane et al.   MOLECULAR AND CELLULAR BIOLOGY

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

(2014) Hao A Duong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

PER1 Phosphorylation Specifies Feeding Rhythm in Mice

(2014) Zhiwei Liu et al.   Cell Reports

A central role for ubiquitination within a circadian clock protein modification code

(2014) Katarina Stojkovic et al.   Frontiers in Molecular Neuroscience

Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function

(2013) Anna Czarna et al.   CELL

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination

(2013) Min-Dian Li et al.   Cell Metabolism

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation

(2013) Yongdo Kwak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

(2013) Peng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock

(2013) G. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The next level of complexity: Crosstalk of posttranslational modifications

(2013) A. Saskia Venne et al.   PROTEOMICS

Casein Kinase I  Mutations in Familial Migraine and Advanced Sleep Phase

(2013) K. C. Brennan et al.   Science Translational Medicine

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

(2012) Markus Stratmann et al.   MOLECULAR CELL

CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α

(2012) S Li et al.   ONCOGENE

PKC  participates in food entrainment by regulating BMAL1

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex

(2012) K. Padmanabhan et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

(2012) Y. Yang et al.   Biology Open

A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation

(2011) Mary L. Spengler et al.   CELL CYCLE

Kinases and phosphatases in the mammalian circadian clock

(2011) Silke Reischl et al.   FEBS LETTERS

Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

(2011) Naval P. Shanware et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock

(2011) Isabelle Schmutz et al.   PLoS One

The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light

(2011) Heather Dehlin Scoma et al.   PLoS One

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

(2011) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

(2011) H.-m. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

(2011) L. DiTacchio et al.   SCIENCE

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

(2011) Guillaume Rey et al.   PLOS BIOLOGY

DYRK1A and Glycogen Synthase Kinase 3 , a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

(2010) N. Kurabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

(2010) Sayako Katada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

(2010) Saurabh Sahar et al.   PLoS One

E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb 

(2010) L. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Identification of RACK1 and Protein Kinase C  as Integral Components of the Mammalian Circadian Clock

(2010) M. S. Robles et al.   SCIENCE

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

(2010) Tsuyoshi Hirota et al.   PLOS BIOLOGY

Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock

(2009) J.-P. Etchegaray et al.   MOLECULAR AND CELLULAR BIOLOGY

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

(2009) H. Yoshitane et al.   MOLECULAR AND CELLULAR BIOLOGY

CK2α phosphorylates BMAL1 to regulate the mammalian clock

(2009) Teruya Tamaru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CKI / -dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

(2009) Y. Isojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

(2009) Y. Tsuchiya et al.   Science Signaling

Post-translational modifications in circadian rhythms

(2009) Arun Mehra et al.   TRENDS IN BIOCHEMICAL SCIENCES

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY

Dual Modification of BMAL1 by SUMO2/3 and Ubiquitin Promotes Circadian Activation of the CLOCK/BMAL1 Complex

(2008) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

Implication of the F-Box Protein FBXL21 in Circadian Pacemaker Function in Mammals

(2008) Hugues Dardente et al.   PLoS One