Review
Cell Biology
Zainab Taleb, Phillip Karpowicz
Summary: The circadian clock is a molecular timekeeper that regulates 24-hour rhythms in animals, impacting behavior and physiology, including metabolic and digestive systems. Animal models targeting circadian clock genes have shown their role in regulating liver diseases, inflammatory bowel disease, colorectal cancer, and obesity. Thus, the circadian clock plays a crucial role in maintaining metabolic and digestive health.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Review
Plant Sciences
Reynel Urrea-Castellanos, Camila Caldana, Rossana Henriques
Summary: Plants integrate external cues and metabolic signals to coordinate the activity of the TOR signalling pathway and adjust growth accordingly. The TOR pathway plays a crucial role in integrating environmental signals and metabolic processes to regulate plant growth and development.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biology
Carlos Rey-Serra, Jessica Tituana, Terry Lin, J. Ignacio Herrero, Veronica Miguel, Coral Barbas, Anna Meseguer, Ricardo Ramos, Amandine Chaix, Satchidananda Panda, Santiago Lamas
Summary: Tubulointerstitial fibrosis is common in chronic kidney disease and its relationship with the molecular clock was investigated. The molecular clock pathway was found to be enriched in damaged tubular epithelial cells with metabolic alterations. The absence of Cry1 and Cry2 correlated with increased fibrosis and altered expression of metabolism-related genes. These results suggest that renal damage disrupts the kidney peripheral molecular clock, leading to metabolic derangement and fibrotic responses.
LIFE SCIENCE ALLIANCE
(2023)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Review
Clinical Neurology
Felix Chan, Judy Liu
Summary: Extensive research has shown a link between circadian rhythm and epilepsy, with various circadian genes implicated in epilepsy pathogenesis. Disruption of metabolic pathways regulated by these genes may mediate the circadian regulation of epilepsy, suggesting a novel therapeutic approach targeting circadian disruption in epilepsy.
Article
Plant Sciences
Nina M. Scheurer, Yogeswari Rajarathinam, Stefan Timm, Christin Kobler, Joachim Kopka, Martin Hagemann, Annegret Wilde
Summary: The study analyzed the effects of mutations in KaiAB1C1 components or the response regulator RpaA on central metabolism in the cyanobacterial strain Synechocystis sp. PCC 6803. Mutants showed imbalanced metabolism in the dark, including increased accumulation of 2-phosphoglycolate and pyruvate family of amino acids. Deletion of the response regulator RpaA had a more pronounced impact compared to the deletion of Kai genes, indicating its role in carbon and nitrogen metabolism during light-to-dark transitions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Dusan Kolarski, Simon Miller, Tsuyoshi Oshima, Yoshiko Nagai, Yugo Aoki, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymanski, Ben L. Feringa, Kenichiro Itami, Tsuyoshi Hirota
Summary: CRY1 and CRY2 proteins are essential components of the circadian clock. Developing CRY1-selective compounds that can be manipulated through light-dependent mechanisms allows for a better understanding of the specific functions of CRY1 and CRY2. By utilizing benzophenone derivatives to interact with the photo lyase region of CRY1, researchers were able to activate CRY1 without affecting CRY2, demonstrating a potential for spatiotemporal regulation of CRY1 activity for health and disease research.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Physiology
Rodrigo Chamorro, Celine Jouffe, Henrik Oster, N. Henriette Uhlenhaut, Sebastian M. Meyhoefer
Summary: This review article discusses the circadian clock's role in regulating physiological and behavioral functions, especially in relation to food intake and metabolic regulation. It emphasizes the importance of meal timing in controlling appetite and metabolic responses. The article provides a fundamental research axis for maintaining a healthy eating behavior by exploring the mechanisms of food intake regulation and focusing on the crucial role of the circadian clock.
Review
Endocrinology & Metabolism
Jun Hirayama, Atsuhiko Hattori, Akihisa Takahashi, Yukihiro Furusawa, Yoshiaki Tabuchi, Masahiro Shibata, Aiko Nagamatsu, Sachiko Yano, Yusuke Maruyama, Hajime Matsubara, Toshio Sekiguchi, Nobuo Suzuki
Summary: Exposure to the space environment has numerous adverse effects on astronauts, including bone loss, sleep disorders, circadian rhythm disruption, cardiovascular and metabolic dysfunction, and impaired immune function. Melatonin, a hormone regulating various physiological functions, appears to play a crucial role in mitigating these effects and protecting against space radiation.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yoshihiko Furuike, Atsushi Mukaiyama, Shin-Ichi Koda, Damien Simon, Dongyan Ouyang, Kumiko Ito-Miwa, Shinji Saito, Eiki Yamashita, Taeko Nishiwaki-Ohkawa, Kazuki Terauchi, Takao Kondo, Shuji Akiyama
Summary: KaiC is a dual ATPase that drives the circadian clock system of cyanobacteria through the coordination of its N-terminal and C-terminal active sites. The activities of these two sites are regulated differently and their delicate interactions drive the assembly and disassembly cycle of KaiA and KaiB.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Zhikang Hu, Ziyan Nie, Chao Yan, Hu Huang, Xianjin Ma, Yupeng Wang, Ning Ye, Gerald A. Tuskan, Xiaohan Yang, Hengfu Yin
Summary: CRASSULACEAN ACID METABOLISM (CAM) is an important photosynthetic pathway for plant adaptation to dry environments. In this study, we identified differentially expressed miRNAs in mesophyll and epidermal tissues of the obligate CAM species Kalanchoe marnieriana under drought treatments. Our results suggest that miR530 might play a role in regulating CAM-related gene expression in Kalanchoe by targeting two tandem zinc knuckle/PLU3 domain encoding genes (TZPs) involved in light signaling and circadian clock pathways.
Review
Endocrinology & Metabolism
Tom M. J. Evers, Liam J. Holt, Simon Alberti, Alireza Mashaghi
Summary: The research explores the interconnected relationship between cellular mechanics and metabolism and their roles in diseases like cancer, cardiovascular diseases, and fibrosis. External forces sensed by the cytoskeleton induce metabolic changes in cells, which then feedback to regulate various levels of cell biology, including mechanical properties. The cross-talk between forces and metabolism has potential diagnostic and therapeutic opportunities for diseases such as cancer and obesity.
Review
Biochemistry & Molecular Biology
Tomoki Sato, Paolo Sassone-Corsi
Summary: Food intake has a profound impact on systemic physiology, and there is a close link between food intake and circadian rhythms. The biological clock controls circadian rhythms through the cyclic expression of genes, and metabolic states also provide feedback to the molecular clock. Nutritional challenges can reprogram the circadian clock, and various factors are involved in the remodeling process.
Review
Nutrition & Dietetics
Norsham Juliana, Liyana Azmi, Nadia Mohd Effendy, Nur Islami Mohd Fahmi Teng, Izuddin Fahmy Abu, Nur Nabilah Abu Bakar, Sahar Azmani, Noor Anisah Abu Yazit, Suhaini Kadiman, Srijit Das
Summary: The circadian system in the human body responds to environmental changes, influences physiological processes, and optimizes behavior. The skeletal muscle circadian clock plays a critical role in lipid and glucose metabolism. Disturbance of the circadian rhythm can affect the musculoskeletal system, and nutritional strategies can help maintain its homeostasis. Active collaborations between nutritionists and physiologists in the field of chronobiology and chrononutrition are essential, as interventions based on these interactions can reduce morbidity and mortality.
Article
Cardiac & Cardiovascular Systems
Arne Thiele, Katja Luettges, Daniel Ritter, Niklas Beyhoff, Elia Smeir, Jana Grune, Julia S. Steinhoff, Michael Schupp, Robert Klopfleisch, Michael Rothe, Nicola Wilck, Hendrik Bartolomaeus, Anna K. Migglautsch, Rolf Breinbauer, Erin E. Kershaw, Gernot F. Grabner, Rudolf Zechner, Ulrich Kintscher, Anna Foryst-Ludwig
Summary: The specific inhibitor of ATGL, Atglistatin, can alleviate catecholamine-induced cardiac damage by exerting anti-fibrotic and anti-apoptotic effects. These effects are likely mediated by non-cardiac tissues.
CARDIOVASCULAR RESEARCH
(2022)
Article
Endocrinology & Metabolism
Karin M. Kirschner, Anna Foryst-Ludwig, Sabrina Gohlke, Chen Li, Roberto E. Flores, Ulrich Kintscher, Michael Schupp, Tim J. Schulz, Holger Scholz
Summary: The study shows that WT1 has a role as a white adipocyte determination factor in intra-abdominal WAT by suppressing thermogenic genes. Reducing the expression of WT1 in these fat depots may represent a novel treatment strategy for metabolic diseases.
Article
Biochemistry & Molecular Biology
Markus Galhuber, Helene Michenthaler, Christoph Heininger, Isabel Reinisch, Christoph Noessing, Jelena Krstic, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Ellen Heitzer, Peter Ulz, Ruth Birner-Gruenberger, Laura Liesinger, Georgia Ngawai Lenihan-Geels, Moritz Oster, Emil Spreitzer, Riccardo Zenezini Chiozzi, Tim J. Schulz, Michael Schupp, Tobias Madl, Albert J. R. Heck, Andreas Prokesch
Summary: This study reveals the mechanisms of p53 signaling during starvation using multiple methods. By utilizing BioID and immunoprecipitation techniques, the interaction network of p53 with metabolic enzymes and kinases was identified. Additionally, transcriptomics analysis identified a starvation-specific transcriptome response. These findings shed new light on our understanding of p53 as a nutrient stress sensor.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Julia S. Steinhoff, Achim Lass, Michael Schupp
Summary: Retinol binding protein 4 (RBP4) is a specific transport protein for lipophilic vitamin A and plays a crucial role in retinol transport and homeostasis. Dysregulation of RBP4 can lead to various conditions and diseases, affecting embryonic development, vision, metabolism, and cardiovascular health. In addition to its transport function, RBP4 may have other important roles.
Article
Immunology
Ivet A. Yordanova, Karsten Juerchott, Svenja Steinfelder, Katrin Vogt, Ulrike Krueger, Anja A. Kuehl, Birgit Sawitzki, Susanne Hartmann
Summary: Intestinal parasitic nematodes can elicit prominent effector Th2-driven host immune responses, but not all infected hosts develop protection against reinfection. Nematode-cured mice harbor memory Th2 cells in both lymphoid and non-lymphoid organs, with particularly prominent expansion and strong parasite-specific Th2 responses observed in peritoneal memory Th2 cells during early recall responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Gabriele Brachtl, Rodolphe Poupardin, Sarah Hochmann, Anna Raninger, Karsten Jurchott, Mathias Streitz, Stephan Schlickeiser, Michaela Oeller, Martin Wolf, Katharina Schallmoser, Hans-Dieter Volk, Sven Geissler, Dirk Strunk
Summary: Donor variation is an important issue limiting cell-based therapies. The use of human platelet lysate (hPL) instead of fetal bovine serum (FBS) to propagate bone marrow stromal cells (BMSCs) can have significant effects on BMSC phenotype and function. Notably, propagation in hPL increased BMSC proliferation and gene expression trajectories, resulting in distinct surface marker signatures after just one passage. The use of FBS as a culture medium led to declining proliferative potential and limited effects on DNA methylation. Culturing BMSCs in xenogenic serum resulted in loss of function during cartilage disk formation and increased clotting risk.
Review
Biochemistry & Molecular Biology
Carina Wagner, Victoria Hois, Ulrike Taschler, Michael Schupp, Achim Lass
Summary: This review explores the structure, function, and physiological role of KIAA1363, and suggests that it may be involved in drug detoxification and hydrolysis of endogenous substrates.
Article
Clinical Neurology
Lil Meyer-Arndt, Julian Braun, Florent Fauchere, Kanika Vanshylla, Lucie Loyal, Larissa Henze, Beate Kruse, Manuela Dingeldey, Karsten Juerchott, Maike Mangold, Ardit Maraj, Andre Braginets, Chotima Boettcher, Andreas Nitsche, Kathrin de la Rosa, Christoph Ratswohl, Birgit Sawitzki, Pavlo Holenya, Ulf Reimer, Leif E. Sander, Florian Klein, Friedemann Paul, Judith Bellmann-Strobl, Andreas Thiel, Claudia Giesecke-Thiel
Summary: This study investigated the impact of disease-modifying therapies (DMTs) on the immunogenicity of SARS-CoV-2 mRNA vaccines in patients with autoimmune diseases. The results showed that patients treated with fingolimod had no immune response even after booster vaccinations, putting them at risk for severe SARS-CoV-2 infections.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Josefine Radke, Elisa Schumann, Julia Onken, Randi Koll, Guliz Acker, Bohdan Bodnar, Carolin Senger, Sascha Tierling, Markus Moebs, Peter Vajkoczy, Anna Vidal, Sandra Hoegler, Petra Kodajova, Dana Westphal, Friedegund Meier, Frank Heppner, Susanne Kreuzer-Redmer, Florian Grebien, Karsten Juerchott, Torben Redmer
Summary: This study uses a multi-OMICS approach and targeted sequencing to uncover the potential programs that control the development of melanoma brain metastases (MBM). The expression of E-cadherin and NGFR is found to classify MBM into different subtypes, and these subtypes control cell migration and proliferation through downstream transcription factors. Additionally, differential methylation analysis can distinguish between different types of MBM.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Larissa Henze, Julian Braun, Lil Meyer-Arndt, Karsten Juerchott, Maike Schlotz, Janine Michel, Marica Grossegesse, Maike Mangold, Manuela Dingeldey, Beate Kruse, Pavlo Holenya, Norbert Mages, Ulf Reimer, Maren Eckey, Karsten Schnatbaum, Holger Wenschuh, Bernd Timmermann, Florian Klein, Andreas Nitsche, Claudia Giesecke-Thiel, Lucie Loyal, Andreas Thiel
Summary: Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. However, the effect of vector vaccines in reactivating pre-existing, cross-reactive immunity is still uncertain.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julian Hackler, Kamil Demircan, Thilo Samson Chillon, Qian Sun, Nino Geisler, Michael Schupp, Kostja Renko, Lutz Schomburg
Summary: Selenium is an essential trace element that affects the expression of SELENOP. A drug screening was performed to identify inhibitors of SELENOP expression, and resveratrol was found to be the most potent inhibitor. The results suggest that resveratrol may increase liver Se levels and selenoprotein expression.
Article
Multidisciplinary Sciences
Georgia Katsioudi, Rene Dreos, Enes S. Arpa, Sevasti Gaspari, Angelica Liechti, Miho Sato, Christian H. Gabriel, Achim Kramer, Steven A. Brown, David Gatfield
Summary: The study demonstrates the importance of nonsense-mediated mRNA decay (NMD) in physiological control, particularly in regulating the circadian clock and gene expression.
Review
Physiology
Matthias Felten, Christof Dame, Gunnar Lachmann, Claudia Spies, Kerstin Rubarth, Felix Balzer, Achim Kramer, Martin Witzenrath
Summary: Patients in the ICU require continuous organ replacement strategies and specialized care, which can disrupt their circadian rhythms and impact their condition. Understanding the complex interactions of circadian effectors and tissue-specific molecular clocks could potentially improve personalized treatment and accelerate recovery for critically ill patients.
Article
Endocrinology & Metabolism
Simon I. I. Dreher, Martin Irmler, Olga Pivovarova-Ramich, Katharina Kessler, Karsten Juerchott, Carsten Sticht, Louise Fritsche, Patrick Schneeweiss, Juergen Machann, Andreas F. H. Pfeiffer, Martin Hrabe de Angelis, Johannes Beckers, Andreas L. L. Birkenfeld, Andreas Peter, Andreas M. M. Niess, Cora Weigert, Anja Moller
Summary: This study examined the response of subcutaneous adipose tissue (SAT) to exercise and compared it with skeletal muscle. The results showed that SAT responds differently to exercise, with reductions in transcripts related to lipid storage and lipogenesis, as well as modulation of the circadian rhythm, which can potentially prevent metabolic syndrome progression towards diabetes.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Cell Biology
Linda van den Berg, Krista Kokki, Sylvia J. Wowro, Konstantin M. Petricek, Onur Deniz, Catrin A. Stegmann, Marius Robciuc, Mari Teesalu, Richard G. Melvin, Anni I. Nieminen, Michael Schupp, Ville Hietakangas
Summary: The Mondo/ChREBP-Mlx gene regulatory network is crucial for sugar metabolism and survival on a high-sugar diet in Drosophila larvae. The clockwork orange (CWO) gene is a mediator of the repressive response to sugar feeding and plays a conserved role in repressing ribosome biogenesis genes.