When should I eat: A circadian view on food intake and metabolic regulation

The circadian clock is a hierarchical timing system regulating most physiological and behavioral functions with a period of approximately 24 h in humans and other mammalian species. The circadian clock drives daily eating rhythms that, in turn, reinforce the circadian clock network itself to anticipate and orchestrate metabolic responses to food intake. Eating is tightly interconnected with the circadian clock and recent evidence shows that the timing of meals is crucial for the control of appetite and metabolic regulation. Obesity results from combined long-term dysregulation in food intake (homeostatic and hedonic circuits), energy expenditure, and energy storage. Increasing evidence supports that the loss of synchrony of daily rhythms significantly impairs metabolic homeostasis and is associated with obesity. This review presents an overview of mechanisms regulating food intake (homeostatic/hedonic) and focuses on the crucial role of the circadian clock on the metabolic response to eating, thus providing a fundamental research axis to maintain a healthy eating behavior.

Automated summary

This review article discusses the circadian clock's role in regulating physiological and behavioral functions, especially in relation to food intake and metabolic regulation. It emphasizes the importance of meal timing in controlling appetite and metabolic responses. The article provides a fundamental research axis for maintaining a healthy eating behavior by exploring the mechanisms of food intake regulation and focusing on the crucial role of the circadian clock.